|
| Status |
Public on Jan 01, 2018 |
| Title |
RNA-sequencing of the Math1-Cre SmoM2 mouse genetic model of medulloblastoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We investigated how misactivation of the Hedgehog (Hh) pathway causes medulloblastoma, and found that Hh signaling induces its transcriptional effector GLI2 to bind the Cdk6 promoter, activate gene expression, and drive uncontrolled cell proliferation. Genetic or pharmacological inhibition of CDK6 repressed the growth of Hh-associated medulloblastoma and prolonged survival in vivo through inhibition of cell proliferation. These findings suggest that CDK6 antagonists may be effective therapies for Hh-associated cancers in humans.
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| |
|
| Overall design |
RNA-sequencing of Math1-Cre Smo2 tumors and SmoM2 controls with transcriptomic analysis of age- and sex-matched littermate controls
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| |
|
| Contributor(s) |
Raleigh DR, Reiter JF |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Oct 05, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
David Raleigh |
| E-mail(s) |
david.r.raleigh@gmail.com
|
| Organization name |
UCSF
|
| Street address |
555 Mission Bay Blvd South
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (6)
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|
| Relations |
| BioProject |
PRJNA413378 |
| SRA |
SRP119458 |
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