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| Status |
Public on Mar 06, 2018 |
| Title |
Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Integration of differential expression (DE) and expression QTL (eQTL) analysis in monocyte-derived macrophages (MDMs) from systemic sclerosis (SSc) patients and healthy controls reveals (i) changes in macrophage transcriptome as an important contributor in SSc and (ii) cis-regulation in GSDMA as a disease risk in macrophages, but not skin.
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| Overall design |
We carried out RNA-sequencing and genome-wide genotyping in MDMs from 57 SSc patients and 15 controls. Our differential expression and expression QTL (eQTL) analysis in SSc was further integrated with epigenetic, expression and eQTL data from skin, monocytes, neutrophils and lymphocytes.
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| Contributor(s) |
Moreno-Moral A, Bagnati M, Behmoaras J, Petretto E |
| Citation(s) |
29348297 |
| |
| Submission date |
Sep 23, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Aida Moreno-Moral |
| Organization name |
Duke-NUS Medical School
|
| Street address |
8 College Road
|
| City |
Singapore |
| ZIP/Postal code |
169857 |
| Country |
Singapore |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (72)
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| Relations |
| BioProject |
PRJNA411909 |
| SRA |
SRP118741 |
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