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| Status |
Public on Jan 18, 2018 |
| Title |
Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We isolated RNAs from hematopoietic stem and progenitor cells (HSPCs). We compared two groups of mice: Cicflox/flox (control) and UBC-cre/ERT2; Cicflox/flox (knockout), two weeks post tamoxifen treatment. Following RNA isolation, RNAseq was performed and gene expression profiles were compared between controls and conditional knockouts.
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| |
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| Overall design |
Examination of gene expression in hematopoietic stem and progenitor cells (HSPCs) in two mouse groups.
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| |
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| Contributor(s) |
Tan Q, Wan Y, Liu Z, Zoghbi HY |
| Citation(s) |
29382756 |
| |
| Submission date |
Sep 05, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Qiumin Tan |
| E-mail(s) |
qiumin@ualberta.ca
|
| Phone |
780-492-1523
|
| Organization name |
University of Alberta
|
| Department |
Cell Biology
|
| Lab |
Qiumin Tan
|
| Street address |
6-16 Medical Sciences Building
|
| City |
Edmonton |
| State/province |
Alberta |
| ZIP/Postal code |
T6G 2H7 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA401747 |
| SRA |
SRP117080 |
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