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| Status |
Public on Jun 15, 2018 |
| Title |
Hippocampus transcriptome analysis of CHD8 Asn2373LysfsX2 heterozygote mutation mice age of P25 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
CHD8, encoding a chromatin remodeling protein, is one of the most frequently mutated genes in autism spectrum disorders. However, how such mutations cause autistic behaviors remain unclear. In mice carrying a heterozygous frame-shift mutation in the Chd8 gene (Asn2373LysfsX2) identified in autistic human individuals, we observed autistic-like behaviors that are much stronger in males than in females, similar to human cases. These behaviors included enhanced mother-seeking ultrasonic vocalizations in pups, mother-attachment behaviors in juveniles, and isolation-induced self-grooming in adults. These behaviors were associated with opposite changes in synaptic excitation/inhibition and neuronal firing in male and female mice, but with strong changes in gene expression in female mice. Therefore, this CHD8 mutation may cause male-preponderant autistic-like behaviors in mice through differential synaptic/neuronal changes and gene expression
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| Overall design |
Hippocampus transcriptome of WT and CHD8 Asn2373LysfsX2 heterozygote mutant mice age of P25 in both sex.
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| Contributor(s) |
Kim E, Jung H, Kang H |
| Citation(s) |
30104731 |
| |
| Submission date |
Sep 01, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Eunjoon Kim |
| E-mail(s) |
kime@kaist.ac.kr
|
| Phone |
82-42-350-2633
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| Organization name |
IBS/KAIST
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| Department |
Center for Synaptic Brain Dysfunctions/Department of Biological Sciences
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| Street address |
Kuseong-dong
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| City |
Daejeon |
| ZIP/Postal code |
305-701 |
| Country |
South Korea |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE87370 |
Comparison of DEG between neonatal male and female mice by CHD8 Asn2373LysfsX2 heterozygote mutation |
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| Relations |
| BioProject |
PRJNA401711 |
| SRA |
SRP131336 |
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