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Series GSE10334 Query DataSets for GSE10334
Status Public on Dec 22, 2008
Title Transcriptomes in Healthy and Diseased Gingival Tissues
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We examined gene expression signatures in healthy and diseased gingival tissues in 90 patients. Analysis of the gingival tissue transcriptome in states of periodontal health and disease may reveal novel insights of the pathobiology of periodontitis.
Keywords: gingival tissue disease state analysis
 
Overall design Ninety non-smokers, 63 with chronic and 27 with aggressive periodontitis, each contributing with >=2 “diseased” interproximal papillae (with bleeding on probing, probing pocket depth >=4mm, and clinical attachment loss >=3mm) and a “healthy” papilla, if available (no BoP, PPD<=4mm and CAL<=2mm). RNA was extracted, amplified, reverse transcribed, labeled, and hybridized with AffymetrixU133Plus2.0 arrays. Transcriptome analysis was conducted on a total of 247 samples (from 183 diseased and 64 healthy sites).
Web link http://www.bioinformatics.ubc.ca/pavlidis/lab/grp/collaborations/papapanou/results/2005-perioPatients/hlth_dis/
 
Contributor(s) Demmer RT, Papapanou PN, Pavlidis P
Citation(s) 18980520
Submission date Jan 30, 2008
Last update date Mar 25, 2019
Contact name Ryan T Demmer
E-mail(s) rtd2106@columbia.edu
Organization name Columbia University
Department Epidemiology
Street address 722 W 168th St.
City New York
State/province NY
ZIP/Postal code 10032
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (247)
GSM261086 Gingival tissue sample 1 from patient 1, Affected site
GSM261087 Gingival tissue sample 2 from patient 1, Affected site
GSM261088 Gingival tissue sample 4 from patient 1, Unaffected site
Relations
BioProject PRJNA105569

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE10334_RAW.tar 1.1 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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