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Series GSE102835 Query DataSets for GSE102835
Status Public on Aug 19, 2017
Title Expression profiling macrophage subsets [P2538]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Experiments expression profile several FACS-sorted pancreas tumor-associated macrophages.
Tumor-associated macrophages (TAMs) are essential components of the cancer microenvironment and play critical roles in the regulation of tumor progression. Optimal therapeutic intervention requires in-depth understanding of the sources that sustain macrophages in malignant tissues. In this study, we investigated the ontogeny of TAMs in murine pancreatic ductal adenocarcinoma (PDAC) models. We identified both inflammatory monocytes and tissue-resident macrophages as sources of TAMs. Unexpectedly, significant portions of pancreas-resident macrophages originate during embryonic development and expand through in situ proliferation during tumor progression. While monocyte-derived TAMs play more potent roles in antigen presentation, embryonically derived TAMs exhibit a pro-fibrotic transcriptional profile, indicative of their role in producing and remodeling extracellular matrix molecules. Collectively, these findings uncover the heterogeneity of TAM origin and functions, and could provide therapeutic insight for PDAC treatment.
Overall design Macrophages were either sorted from the normal pancreas or PDAC tissues of wild-type, or KPC or FLT3-CRE/LSL-YFP mice.
Contributor(s) Zhu Y, Knolhoff B, DeNardo D
Citation(s) 28930665
Submission date Aug 18, 2017
Last update date Jul 25, 2021
Contact name DAvid DeNardo
Organization name Washington University
Department Medicine
Street address 660 S. Euclid Ave
City St. Louis
State/province Mo
ZIP/Postal code 63110
Country USA
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (12)
GSM2747036 23428-24453T-Pos [P2538_1]
GSM2747037 23438-24457T-Neg [P2538_2]
GSM2747038 23432-24457T-Pos [P2538_3]
This SubSeries is part of SuperSeries:
GSE102836 Expression profiling macrophage subsets
BioProject PRJNA399232

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE102835_RAW.tar 110.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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