Expression profiling by high throughput sequencing
Summary
DES is a synthetic estrogen that is associated with adverse effects on reproductive organs. Our group has employed estrogen receptor (ER) α knockout (αERKO) mice to gain insight into the contribution of ER a in DES-induced toxicity following neonatal exposure.
Overall design
Mice were neonatally exposed to DES. The SVs or uterus were collected at week 10. Genome-wide transcriptome was performed by RNA-Seq.
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