|
| Status |
Public on Jul 29, 2017 |
| Title |
Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To determine if there is an APOE isoform-specific response to TBI we performed controlled cortical impact on 3-month-old mice expressing human APOE3 or APOE4 isoforms. Following injury, we used several behavior paradigms to test for anxiety and learning and found that APOE3 and APOE4 targeted replacement mice demonstrate cognitive impairments following moderate TBI. Transcriptional profiling 14 days following injury revealed a significant effect of TBI, which was similar in both genotypes.
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| |
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| Overall design |
Examination of the effectes of TBI on APOE expressing mice
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| |
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| Contributor(s) |
Castranio EL, Mounier A, Wolfe CM, Nam KN, Fitz NF, Letronne F, Schug J, Koldamova R, Lefterov I |
| Citation(s) |
28502803 |
| |
| Submission date |
Jul 28, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Iliya Lefterov |
| E-mail(s) |
iliya.lefterov@pitt.edu
|
| Organization name |
University of Pittsburgh
|
| Department |
Enviromantal and Occupational health
|
| Lab |
Lefterov/Koldamova
|
| Street address |
130 De Soto Street
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15261 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (32)
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|
| Relations |
| BioProject |
PRJNA396209 |
| SRA |
SRP113777 |
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