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| Status |
Public on Aug 30, 2017 |
| Title |
Serum microRNA profile of Her2 positive metastatic breast cancer patients |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Some HER2 positive breast cancer patients are refractory to trastuzumab therapy. MicroRNAs have been used to predict therapeutic effects for various cancers, and our study suggests that the serum-based miRNA signature can effectively distinguish HER2+ MBC patients who are sensitive to trastuzumab from those are resistant.
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| Overall design |
We collected the serum samples of HER2+ metastatic breast cancer patients before receiving first-line chemotherapy with trastuzumab for miRNA analysis, then we used miRNA microarray to obtain microRNA profile from 103 patients randomly selected from 254 patients as the training group, with 61 of them responding to the treatment while the rest 42 were resistant.
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| Contributor(s) |
Liu J, Li H |
| Citation(s) |
29691399 |
| |
| Submission date |
Jul 25, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Jiang Liu |
| E-mail(s) |
zyliujiang@163.com
|
| Organization name |
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
|
| Street address |
107 Yanjiang West Road
|
| City |
Guangzhou |
| ZIP/Postal code |
510080 |
| Country |
China |
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| Platforms (1) |
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| Samples (103)
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| Relations |
| BioProject |
PRJNA395684 |
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