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| Status |
Public on Nov 27, 2018 |
| Title |
Transcriptomes of normal liver and spontaneous hepatocellular carcinoma in C3HeB/FeJ male mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The goal of this study was to identify and analyze differential gene expression between normal liver and tumor tissue responding or not to potential treatments. A second goal was to compare the mouse results with that from analysis of human differential gene expression for normal liver and hepatocellular carcinoma.
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| Overall design |
Mice were allowed to reach 10-months-old then assessed for the presence of tumors. Animals with tumors were subjected to treatment protocols to be described else where. After six 28-day cycles of treatment, mice were euthanized and tissue collected for RNA isolation that was used for next generation sequencing by Beckman Coulter. Results were analyzed using Pigengene package.
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| |
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| Contributor(s) |
Zavadil JA, Walter CA, Zare H |
| Citation(s) |
30365185 |
| |
| Submission date |
Jul 24, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Yidong Chen |
| E-mail(s) |
cheny8@uthscsa.edu
|
| Phone |
2105629163
|
| Organization name |
UT Health Science Center at San Antonio
|
| Department |
Population Health Sciences
|
| Street address |
8403 Floyd Curl Drive, MSC 7784
|
| City |
San Antonio |
| State/province |
Texas |
| ZIP/Postal code |
78229 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA395583 |
| SRA |
SRP113485 |
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