|
| Status |
Public on Oct 25, 2017 |
| Title |
Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Disruption of Ski/Smad4 license Th17 differentiation. TGF-b-Ski-Smad4-RORgt-Th17 axis
|
| |
|
| Overall design |
Examination of transcriptome under two different conditions (WT vs.Smad4 KO), two different treatment (Th0 and IL6) and three time point( 0hr, 3hr and 12hr)
|
| |
|
| Contributor(s) |
Zhang S, Xu X, Wan Y |
| Citation(s) |
29072299 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 AI123193 |
Functional protein networks underlying T cell growth, proliferation and differentiation |
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
Yisong Wan |
|
| |
| Submission date |
Jul 17, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Yisong Wan |
| Organization name |
University of North Carolina-Chapel Hill
|
| Department |
Lineberger Comprehensive Cancer Center
|
| Lab |
Marsico Hall Rm 5229J
|
| Street address |
125 Mason Farm Road
|
| City |
Chapel Hill |
| State/province |
NC |
| ZIP/Postal code |
27599 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA394763 |
| SRA |
SRP112617 |
Less...
More...