|
| Status |
Public on Dec 14, 2018 |
| Title |
The effect of genetic background on cognitive and pathological traits: AD-BXD |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Female C57BL/6J mice hemizygous for the 5XFAD transgene (MMRRC Stock No #34848-JAX) were bred to males from BXD strains, which do not carry the 5XFAD transgene. The resulting F1 progeny were monitored throughout their lifespan to evaluate the effect of genetic background on cognitive and pathological traits. All of the mice were fear conditioned and sacrificed within 30 minutes of testing. On the sample records, the characteristics: age field provides the age at which fear conditioning, sacrifice, and tissue collection occurred. Samples here come from various AD-BXD lines and their non-transgenic (Ntg) littermate counterparts at either 6 or 14 months of age.
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| Overall design |
133 samples, 64 Ntg and 69 AD. For final by-strain analysis, samples were averaged into strain/age/genotype/sex groups (For example, all D2 6mo 5XFAD males were averaged for final by-strain analysis)
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| |
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| Contributor(s) |
Richholt R, Neuner S, Huentelman M, Kaczorowski C |
| Citation(s) |
30595332, 33042997, 38769398 |
| |
| Submission date |
Jul 11, 2017 |
| Last update date |
Jun 05, 2024 |
| Contact name |
Catherine C Kaczorowski |
| E-mail(s) |
catherine.kaczorowski@jax.org
|
| Organization name |
The Jackson Laboratory
|
| Street address |
600 Main Street
|
| City |
Bar Harbor |
| State/province |
ME |
| ZIP/Postal code |
04609 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (133)
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| Relations |
| BioProject |
PRJNA393799 |
| SRA |
SRP111520 |
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