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| Status |
Public on Sep 15, 2017 |
| Title |
Lineage-specific genetic innovations streamline the genomes of Armillaria species to pathogenesis |
| Organism |
Armillaria ostoyae |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Armillaria species are devastating forest pathogens that are among the largest terrestrial organisms on Earth. They explore hosts and achieve immense colony sizes by rhizomorphs, root-like multicellular structures of clonal dispersal. To resolve the genetic bases of their unique biology, we sequenced and analyzed genomes of 4 Armillaria species and performed RNA-Seq on 7 invasive and reproductive developmental stages. Comparison with 22 basidiomycete fungi revealed a significant genome expansion in Armillaria, affecting several pathogenicity-related genes, lignocellulose degrading enzymes and lineage-specific genes involved in rhizomorph development. Rhizomorphs express an evolutionarily young transcriptome and share their morphogenetic machinery with fruiting bodies, providing genetic and regulatory insights into complex multicellularity in fungi. Our results suggest that the evolution of the unique dispersal and pathogenicity mechanisms of Armillaria has drawn upon ancestral genetic toolkits for wood-decay, morphogenesis and complex multicellularity.
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| Overall design |
30 samples corresponding to 10 developmental stages were analyzed. Each developmental stage contains 3 biological replicates.
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| Contributor(s) |
Sipos G, Prasanna AN, Walter MC, O'Connor E, Balint B, Krizsan K, Kiss B, Hess J, Varga T, Slot J, Riley R, Boka B, Rigling D, Barry K, Lee J, Mihaltcheva S, LaButti K, Lipzen A, Waldron R, Moloney NM, Sperisen C, Kredics L, Vagvolgyi C, Patrignani A, Fitzpatrick D, Nagy I, Doyle S, Anderson J, Grigoriev IV, Guldener U, Munsterkotter M, Nagy LG |
| Citation(s) |
29085064 |
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| Submission date |
Jun 19, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Balazs Balint |
| E-mail(s) |
balintb@seqomics.hu
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| Phone |
0036304276152
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| Organization name |
Seqomics Ltd
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| Street address |
Vallalkozok street
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| City |
7 |
| State/province |
Csongrad |
| ZIP/Postal code |
6782 |
| Country |
Hungary |
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| Platforms (1) |
| GPL23605 |
Illumina NextSeq 500 (Armillaria ostoyae) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA390997 |
| SRA |
SRP109671 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE100213_ARO_RPKM_22Nov2016.csv.gz |
4.4 Mb |
(ftp)(http) |
CSV |
| GSE100213_RAW.tar |
31.9 Mb |
(http)(custom) |
TAR (of CSV) |
| GSE100213_p3_i2_t47428_Arm_ostoy_v2.gff3.gz |
2.5 Mb |
(ftp)(http) |
GFF3 |
| GSE100213_p3_i2_t47428_Arm_ostoy_v2.scaf.txt.gz |
17.9 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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