| Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-kappa activation and APOBEC3G induction. | Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction.
Sarkar MK, Uppala R, Zeng C, Billi AC, Tsoi LC, Kidder A, Xing X, Perez White BE, Shao S, Plazyo O, Sirobhushanam S, Xing E, Jiang Y, Gallagher KA, Voorhees JJ, Kahlenberg JM, Gudjonsson JE., Free PMC Article | 05/8/2023 |
| Identification of the prognostic value of Th1/Th2 ratio and a novel prognostic signature in basal-like breast cancer. | Identification of the prognostic value of Th1/Th2 ratio and a novel prognostic signature in basal-like breast cancer.
Xiao Y, Huang Y, Jiang J, Chen Y, Wei C., Free PMC Article | 02/4/2023 |
| IFN-kappa is critical for normal wound repair and is decreased in diabetic wounds. | IFN-κ is critical for normal wound repair and is decreased in diabetic wounds.
Wolf SJ, Audu CO, Joshi A, denDekker A, Melvin WJ, Davis FM, Xing X, Wasikowski R, Tsoi LC, Kunkel SL, Gudjonsson JE, O'Riordan MX, Kahlenberg JM, Gallagher KA., Free PMC Article | 05/14/2022 |
| IFN-kappa Is a Rheostat for Development of Psoriasiform Inflammation. | IFN-κ Is a Rheostat for Development of Psoriasiform Inflammation.
Gharaee-Kermani M, Estadt SN, Tsoi LC, Wolf-Fortune SJ, Liu J, Xing X, Theros J, Reed TJ, Lowe L, Gruszka D, Ward NL, Gudjonsson JE, Kahlenberg JM., Free PMC Article | 01/15/2022 |
| Interferon Kappa Is Important for Keratinocyte Host Defense against Herpes Simplex Virus-1. | Interferon Kappa Is Important for Keratinocyte Host Defense against Herpes Simplex Virus-1.
Li Y, Song Y, Zhu L, Wang X, Richers B, Leung DYM, Bin L., Free PMC Article | 02/20/2021 |
| MDA5(+) Dermatomyositis Is Associated with Stronger Skin Type I Interferon Transcriptomic Signature with Upregulation of IFN-kappa Transcript. | MDA5(+) Dermatomyositis Is Associated with Stronger Skin Type I Interferon Transcriptomic Signature with Upregulation of IFN-κ Transcript.
Cassius C, Amode R, Delord M, Battistella M, Poirot J, How-Kit A, Lepelletier C, Jachiet M, de Masson A, Frumholtz L, Cordoliani F, Boccara D, Lehmann-Che J, Wong J, Dubanchet S, Alberdi AJ, Merandet M, Bagot M, Bensussan A, Bouaziz JD, Le Buanec H. | 01/9/2021 |
| The loss of E5 in keratinocytes maintaining the complete HPV16 genome results in the derepression of IFNK transcription and subsequent JAK/STAT-dependent upregulation of several IFN-stimulated genes (ISGs) at both the mRNA and protein levels. | Human Papillomavirus 16 E5 Inhibits Interferon Signaling and Supports Episomal Viral Maintenance.
Scott ML, Woodby BL, Ulicny J, Raikhy G, Orr AW, Songock WK, Bodily JM., Free PMC Article | 06/13/2020 |
| investigation of common variable immunodeficiency (CVID) from 2 German families; report on the occurrence of a common and one novel truncating IFNK mutation in cases with CVID; the frequency distribution of c.30_31insTGTT in cases and controls as well as the observed segregation patterns in CVID families exclude IFNK mutations as major risk factor in CVID | Limited role of interferon-kappa (IFNK) truncating mutations in common variable immunodeficiency.
Atschekzei F, Dörk T, Schürmann P, Geffers R, Witte T, Schmidt RE. | 03/3/2018 |
| These results suggest that high-risk human papillomavirus 31 target interferon kappa to prevent Sp100 expression and identify Sp100 as an interferon-stimulated gene with anti-human papillomavirus activity. | Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins.
Habiger C, Jäger G, Walter M, Iftner T, Stubenrauch F., Free PMC Article | 05/14/2016 |
| This study demonstrates that E2 proteins of high risk human papillomavirus reduce STING and IFN-kappa transcription. | E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-κ transcription in keratinocytes.
Sunthamala N, Thierry F, Teissier S, Pientong C, Kongyingyoes B, Tangsiriwatthana T, Sangkomkamhang U, Ekalaksananan T., Free PMC Article | 04/2/2016 |
| The viral E6 and E7 oncogenes are sufficient for interferon-kappa repression, with E6 being mainly responsible. | High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression.
Reiser J, Hurst J, Voges M, Krauss P, Münch P, Iftner T, Stubenrauch F., Free PMC Article | 11/26/2011 |
| IFN-kappa is down-regulated in cervical keratinocytes harboring HPV, which may be a contributing factor in the progression of a cervical lesion | IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes.
DeCarlo CA, Severini A, Edler L, Escott NG, Lambert PF, Ulanova M, Zehbe I. | 01/22/2011 |
| Studied IFNK single nucleotide polymorphisms in 3982 Systemic lupus erythematosus cases and 4275 controls. | The role of genetic variation near interferon-kappa in systemic lupus erythematosus.
Harley IT, Niewold TB, Stormont RM, Kaufman KM, Glenn SB, Franek BS, Kelly JA, Kilpatrick JR, Hutchings D, Divers J, Bruner GR, Edberg JC, McGwin G Jr, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá-Pérez LM, Merrill JT, Gilkeson GS, Vyse TJ, Alarcón-Riquelme ME, Cho SK, Jacob CO, Alarcón GS, Moser KL, Gaffney PM, Kimberly RP, Bae SC, Langefeld CD, Harley JB, Guthridge JM, James JA, Harley IT, Niewold TB, Stormont RM, Kaufman KM, Glenn SB, Franek BS, Kelly JA, Kilpatrick JR, Hutchings D, Divers J, Bruner GR, Edberg JC, McGwin G Jr, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá-Pérez LM, Merrill JT, Gilkeson GS, Vyse TJ, Alarcón-Riquelme ME, Cho SK, Jacob CO, Alarcón GS, Moser KL, Gaffney PM, Kimberly RP, Bae SC, Langefeld CD, Harley JB, Guthridge JM, James JA., Free PMC Articles: PMC2914299, PMC2914299 | 01/1/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesThe role of genetic variation near interferon-kappa in systemic lupus erythematosus.
Harley IT, Niewold TB, Stormont RM, Kaufman KM, Glenn SB, Franek BS, Kelly JA, Kilpatrick JR, Hutchings D, Divers J, Bruner GR, Edberg JC, McGwin G Jr, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá-Pérez LM, Merrill JT, Gilkeson GS, Vyse TJ, Alarcón-Riquelme ME, Cho SK, Jacob CO, Alarcón GS, Moser KL, Gaffney PM, Kimberly RP, Bae SC, Langefeld CD, Harley JB, Guthridge JM, James JA, Harley IT, Niewold TB, Stormont RM, Kaufman KM, Glenn SB, Franek BS, Kelly JA, Kilpatrick JR, Hutchings D, Divers J, Bruner GR, Edberg JC, McGwin G Jr, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá-Pérez LM, Merrill JT, Gilkeson GS, Vyse TJ, Alarcón-Riquelme ME, Cho SK, Jacob CO, Alarcón GS, Moser KL, Gaffney PM, Kimberly RP, Bae SC, Langefeld CD, Harley JB, Guthridge JM, James JA. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA, Goldstein AM. | 09/15/2010 |
| This is the first report showing an epigenetic silencing of type I IFN after HPV16 oncogene expression | Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells.
Rincon-Orozco B, Halec G, Rosenberger S, Muschik D, Nindl I, Bachmann A, Ritter TM, Dondog B, Ly R, Bosch FX, Zawatzky R, Rösl F. | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
Liu C, Batliwalla F, Li W, Lee A, Roubenoff R, Beckman E, Khalili H, Damle A, Kern M, Furie R, Dupuis J, Plenge RM, Coenen MJ, Behrens TW, Carulli JP, Gregersen PK., Free PMC Article | 07/23/2008 |
| IFN-kappa is able to directly modulate cytokine release from monocytes and dendritic cells, inhibit inducible IL-12 release from monocytes, and bind strongly to heparin. | Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system.
Nardelli B, Zaritskaya L, Semenuk M, Cho YH, LaFleur DW, Shah D, Ullrich S, Girolomoni G, Albanesi C, Moore PA. | 01/21/2010 |