| Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease. | Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease.
Alexander KK, Naaldijk Y, Fasiczka R, Brahmia B, Chen T, Hilfiker S, Kennedy EJ. | 04/10/2024 |
| The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons. | The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons.
Mamais A, Sanyal A, Fajfer A, Zykoski CG, Guldin M, Riley-DiPaolo A, Subrahmanian N, Gibbs W, Lin S, LaVoie MJ., Free PMC Article | 02/21/2024 |
| Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression. | Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression.
Wu T, Zhang Y, Han Q, Lu X, Cheng Y, Chen J, Sha J, Xia W. | 09/18/2023 |
| Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif containing ciliary targeting sequence. | Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif containing ciliary targeting sequence.
Mahajan D, Madugula V, Lu L., Free PMC Article | 06/1/2023 |
| Transcription Activation of Rab8A by PEA3 Augments Progression of Esophagus Cancer by Activating the Wnt/beta-Catenin Signaling Pathway. | Transcription Activation of Rab8A by PEA3 Augments Progression of Esophagus Cancer by Activating the Wnt/β-Catenin Signaling Pathway.
Cai S, Liu X, Gao W, Ye L, Zhong Q, Zhang X., Free PMC Article | 02/24/2023 |
| Circular RNA 0001823 aggravates the growth and metastasis of the cervical cancer cells through modulating the microRNA-613/RAB8A axis. | Circular RNA 0001823 aggravates the growth and metastasis of the cervical cancer cells through modulating the microRNA-613/RAB8A axis.
Ji H, Hu N., Free PMC Article | 04/30/2022 |
| Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease. | Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease.
Zhang Q, Wu L, Bai B, Li D, Xiao P, Li Q, Zhang Z, Wang H, Li L, Jiang Q., Free PMC Article | 03/19/2022 |
| Down-regulation of microRNA-30d-5p is associated with gestational diabetes mellitus by targeting RAB8A. | Down-regulation of microRNA-30d-5p is associated with gestational diabetes mellitus by targeting RAB8A.
Zhang L, Li K, Tian S, Wang XQ, Li JH, Dong YC, Xia HF, Ma X. | 01/15/2022 |
| Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. | Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR., Free PMC Article | 01/8/2022 |
| The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response. | The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response.
Lian H, Jiang K, Tong M, Chen Z, Liu X, Galán JE, Gao X., Free PMC Article | 09/4/2021 |
| Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2. | Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2.
Waschbüsch D, Purlyte E, Pal P, McGrath E, Alessi DR, Khan AR., Free PMC Article | 04/17/2021 |
| Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR Signaling via FGFR Signaling. | Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR Signaling via FGFR Signaling.
Choi J, Sung JY, Lee S, Yoo J, Rongo C, Kim YN, Shim J., Free PMC Article | 03/6/2021 |
| The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. | The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members.
Rai A, Bleimling N, Vetter IR, Goody RS., Free PMC Article | 09/19/2020 |
| Phosphorylation of Ser111 in Rab8a modulates Rabin8-dependent activation by perturbation of side chain interaction networks. | Phosphorylation of Ser111 in Rab8a Modulates Rabin8-Dependent Activation by Perturbation of Side Chain Interaction Networks.
Pourjafar-Dehkordi D, Vieweg S, Itzen A, Zacharias M. | 06/27/2020 |
| Pathogenic LRRK2 causes the centrosomal accumulation not only of phosho-RAB8 but also of phospho-RAB10, and the effects on centrosomal cohesion are dependent on RAB8, RAB10 and RILPL1. | RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
Lara Ordónez AJ, Fernández B, Fdez E, Romo-Lozano M, Madero-Pérez J, Lobbestael E, Baekelandt V, Aiastui A, López de Munaín A, Melrose HL, Civiero L, Hilfiker S., Free PMC Article | 05/30/2020 |
| it was suggested that ARHGEF10 is involved in the regulation of Rab6A and Rab8A localization and invasion of breast carcinoma cells, in which Rab8 also acts via regulation of membrane trafficking. | Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic.
Shibata S, Teshima Y, Niimi K, Inagaki S., Free PMC Article | 04/11/2020 |
| Rab8 GTPase can regulate Klotho-mediated inhibition of Wnt signaling activity by modulating translocation of Klotho onto the cell surface. | Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer.
Chen B, Huang S, Pisanic Ii TR, Stark A, Tao Y, Cheng B, Li Y, Wei Y, Zhao W, Wang TH, Wu J., Free PMC Article | 04/4/2020 |
| Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8. | Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.
Esposito A, Ventura V, Petoukhov MV, Rai A, Svergun DI, Vanoni MA., Free PMC Article | 01/25/2020 |
| these findings suggest that, by impairing RAB8A function, pathogenic G2019S LRRK2 deregulates endolysosomal transport and endocytic recycling events. | The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.
Rivero-Ríos P, Romo-Lozano M, Madero-Pérez J, Thomas AP, Biosa A, Greggio E, Hilfiker S., Free PMC Article | 10/19/2019 |
| We demonstrated that deficiency of GCase(GBA1) leads to a reduction of C18-ceramide species and altered intracellular localization of Rab8a, a small GTPase implicated in secretory autophagy, that contributed to impaired secretion of a-synuclein and accumulation of intracellular a-synuclein. | Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function.
Kim MJ, Jeon S, Burbulla LF, Krainc D., Free PMC Article | 02/16/2019 |
| Our findings reveal a new function of LRRK2 mediated by Rab8a phosphorylation and related to various centrosomal defects. | Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S., Free PMC Article | 11/10/2018 |
| Rab8a is phosphorylated by LRRK2.Phosphorylation of Rab8a plays important role in the fusion and enlargement of lipid droplets. | LRRK2 mediated Rab8a phosphorylation promotes lipid storage.
Yu M, Arshad M, Wang W, Zhao D, Xu L, Zhou L., Free PMC Article | 09/15/2018 |
| C9ORF72 causes suboptimal autophagy | C9ORF72 is a GDP/GTP exchange factor for Rab8 and Rab39 and regulates autophagy.
Corbier C, Sellier C., Free PMC Article | 04/28/2018 |
| GRAF1-mediated removal of Rab8 from the cell surface restricts its activity during protrusion formation, thereby facilitating dynamic adjustment of the polarity axis. | Endocytic turnover of Rab8 controls cell polarization.
Vidal-Quadras M, Holst MR, Francis MK, Larsson E, Hachimi M, Yau WL, Peränen J, Martín-Belmonte F, Lundmark R., Free PMC Article | 08/12/2017 |
| the TNPO1-Rab8-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia. | A ternary complex comprising transportin1, Rab8 and the ciliary targeting signal directs proteins to ciliary membranes.
Madugula V, Lu L., Free PMC Article | 08/5/2017 |