| GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A. | GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A.
Schratter G, Scheruebel S, Langthaler S, Ester K, Pelzmann B, Ghaffari-Tabrizi-Wizsy N, Rezania S, Gorischek A, Platzer D, Zorn-Pauly K, Ahammer H, Prokesch A, Stanzer S, Devaney TTJ, Schmidt K, Jahn SW, Prassl R, Bauernhofer T, Schreibmayer W., Free PMC Article | 11/21/2020 |
| A constricted opening in Kir channels does not impede potassium conduction. | A constricted opening in Kir channels does not impede potassium conduction.
Black KA, He S, Jin R, Miller DM, Bolla JR, Clarke OB, Johnson P, Windley M, Burns CJ, Hill AP, Laver D, Robinson CV, Smith BJ, Gulbis JM., Free PMC Article | 08/29/2020 |
| Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation. | Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation.
Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, Miura K, Ueshima H, Komuro I, Yamagishi M, Horie M, Kawakami K, Furukawa T, Koizumi A, Kurachi Y, Sakata Y, Minamino T, Kitakaze M, Takashima S. | 02/15/2020 |
| Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation | Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation.
Tateyama M, Kubo Y., Free PMC Article | 03/2/2019 |
| these data suggest that patients with estrogen receptor positive breast cancer might be stratified into high risk and low risk groups based on the KCNJ3 levels in the tumor | KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients.
Kammerer S, Sokolowski A, Hackl H, Platzer D, Jahn SW, El-Heliebi A, Schwarzenbacher D, Stiegelbauer V, Pichler M, Rezania S, Fiegl H, Peintinger F, Regitnig P, Hoefler G, Schreibmayer W, Bauernhofer T., Free PMC Article | 02/24/2018 |
| Results clearly corroborate that overexpression of GIRK1 protein exerts profound effects on wound healing, chemoinvasion and cellular motility in the MCF-7 breast cancer cell line suggesting a role to promote invasion and metastasis. | Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner.
Rezania S, Kammerer S, Li C, Steinecker-Frohnwieser B, Gorischek A, DeVaney TT, Verheyen S, Passegger CA, Tabrizi-Wizsy NG, Hackl H, Platzer D, Zarnani AH, Malle E, Jahn SW, Bauernhofer T, Schreibmayer W., Free PMC Article | 09/30/2017 |
| GIRK1/GIRK4 hetero-tetramers are not activated by Na+, but rather are in a permanent state of high responsiveness to G proteins beta-gamma, suggesting that the GIRK1 subunit functions like a GIRK4 subunit with Na+ permanently bound. | The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers.
Touhara KK, Wang W, MacKinnon R., Free PMC Article | 05/20/2017 |
| The findings of this study suggest that variations in KCNJ3 genes are associated with both mild and severe persistent breast pain after breast cancer surgery. | Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery.
Langford DJ, Paul SM, West CM, Dunn LB, Levine JD, Kober KM, Dodd MJ, Miaskowski C, Aouizerat BE. | 11/7/2015 |
| For KCNJ3 rs7574878, individuals who were heterozygous or homozygous for the rare G allele (TT versus TG+ GG) had a 48% reduction in the odds of reporting preoperative breast pain. | Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery.
Langford DJ, West C, Elboim C, Cooper BA, Abrams G, Paul SM, Schmidt BL, Levine JD, Merriman JD, Dhruva A, Neuhaus J, Leutwyler H, Baggott C, Sullivan CW, Aouizerat BE, Miaskowski C., Free PMC Article | 01/10/2015 |
| we show that Kir3.1, in the absence of trafficking partner subunits, can exit the endoplasmic reticulum (ER) and reach the Golgi (though not the plasma membrane) | A novel, radiolabel-free pulse chase strategy to study Kir3 channel ontogeny.
Zylbergold P, Sleno R, Hébert TE. | 01/4/2014 |
| In the dorsal horn of the developing rat, K(ir)3.1 and K(ir)3.2 were expressed at mature levels from birth. | Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn.
Blankenship ML, Coyle DE, Baccei ML., Free PMC Article | 07/27/2013 |
| Conformational changes at the Gbetagamma/Kir3 interface were lost when Kir3.1 subunits were replaced. | Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors.
Richard-Lalonde M, Nagi K, Audet N, Sleno R, Amraei M, Hogue M, Balboni G, Schiller PW, Bouvier M, Hébert TE, Pineyro G., Free PMC Article | 06/1/2013 |
| These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the "channelopathy theory of psychiatric illnesses". | Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population.
Yamada K, Iwayama Y, Toyota T, Ohnishi T, Ohba H, Maekawa M, Yoshikawa T., Free PMC Article | 04/14/2012 |
| Kir3.1 channel is involved in the TLR4-mediated signal at an early event by facilitating the recruitment of TLR4 into lipid raft. | Kir3.1 channel is functionally involved in TLR4-mediated signaling.
Jo HY, Kim SY, Lee S, Jeong S, Kim SJ, Kang TM, Lee KY. | 07/23/2011 |
| halothane predominantly interferes with Gbetagamma-mediated Kir3 currents, such as those functioning during inhibitory synaptic activity | G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels.
Styer AM, Mirshahi UL, Wang C, Girard L, Jin T, Logothetis DE, Mirshahi T., Free PMC Article | 02/26/2011 |
| The very high abundance of mRNA's encoding GIRK1 together with the presence of GIRK1 protein suggests a pathophysiological role in breast cancer | Cloning and characterisation of GIRK1 variants resulting from alternative RNA editing of the KCNJ3 gene transcript in a human breast cancer cell line.
Wagner V, Stadelmeyer E, Riederer M, Regitnig P, Gorischek A, Devaney T, Schmidt K, Tritthart HA, Hirschberg K, Bauernhofer T, Schreibmayer W. | 08/23/2010 |
| We identified several known single nucleotide polymorphisms in KCNJ3 and KCNJ5, but no mutations in either of the genes. | Genetic variation in the inwardly rectifying K channel subunits KCNJ3 (GIRK1) and KCNJ5 (GIRK4) in patients with sinus node dysfunction.
Holmegard HN, Theilade J, Benn M, Duno M, Haunso S, Svendsen JH, Holmegard HN, Theilade J, Benn M, Duno M, Haunso S, Svendsen JH. | 07/26/2010 |
| S385 identified as in vitro phosphorylation site. Mutation of this residue to alanine resulted in reduced sensitivity of Kir3.1* currents to H89 & Forskolin, confirming in vivo role for this novel site of the Kir3.1 channel subunit in regulation by PKA. | Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit.
Rusinova R, Shen YM, Dolios G, Padovan J, Yang H, Kirchberger M, Wang R, Logothetis DE., Free PMC Article | 01/21/2010 |
| Sar 1 H79G and Rab 1 S25N mutants efficiently blocked the plasma membrane trafficking of the Kir3.1/Kir3.4 complex however they did not block the Gbeta1gamma2/Kir3.1 interaction. Gbeta1-4 can interact with Kir3.1 in the absence of Kir3.4. | Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes.
Robitaille M, Ramakrishnan N, Baragli A, Hébert TE. | 01/21/2010 |
| GIRK1 was overexpressed in breast carcinoma suggesting its involvement in proliferation and oncogenesis and its possible use as a putative pharmaceutical target. | Expression of K+ channels in normal and cancerous human breast.
Brevet M, Ahidouch A, Sevestre H, Merviel P, El Hiani Y, Robbe M, Ouadid-Ahidouch H. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB. Genetic variation in the inwardly rectifying K channel subunits KCNJ3 (GIRK1) and KCNJ5 (GIRK4) in patients with sinus node dysfunction.
Holmegard HN, Theilade J, Benn M, Duno M, Haunso S, Svendsen JH, Holmegard HN, Theilade J, Benn M, Duno M, Haunso S, Svendsen JH. Suggestive evidence for association of two potassium channel genes with different idiopathic generalised epilepsy syndromes.
Chioza B, Osei-Lah A, Wilkie H, Nashef L, McCormick D, Asherson P, Makoff AJ. | 03/13/2008 |
| GIRK1 and GIRK2 channels, but not GIRK3 or GIRK4, may may activate signaling pathways in development of lung cancer | Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines.
Plummer HK 3rd, Dhar MS, Cekanova M, Schuller HM., Free PMC Article | 01/21/2010 |
| that GIRK channels are important functional effectors of the P2Y(12) receptor in human platelets. | Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses.
Shankar H, Murugappan S, Kim S, Jin J, Ding Z, Wickman K, Kunapuli SP. | 01/21/2010 |
| glutamate residue at the C terminus regulates activity -- implications for Andersen Disease (inward rectifier potassium channel 2; IRK2) | A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome.
Chen L, Kawano T, Bajic S, Kaziro Y, Itoh H, Art JJ, Nakajima Y, Nakajima S., Free PMC Article | 01/21/2010 |