| Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response. | Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response.
Nagelberg AL, Sihota TS, Chuang YC, Shi R, Chow JLM, English J, MacAulay C, Lam S, Lam WL, Lockwood WW., Free PMC Article | 09/11/2024 |
| A peptide encoded by the circular form of the SHPRH gene induces apoptosis in neuroblastoma cells. | A peptide encoded by the circular form of the SHPRH gene induces apoptosis in neuroblastoma cells.
Gao J, Pan H, Li J, Jiang J, Wang W., Free PMC Article | 03/1/2024 |
| KMT2B promotes SHPRH expression to regulate (131)I sensitivity in thyroid carcinoma cells by affecting FYN protein stability. | KMT2B promotes SHPRH expression to regulate (131)I sensitivity in thyroid carcinoma cells by affecting FYN protein stability.
Chen W, Zhong M, Yu J, Xie R, Zhou T, Zhang S, Xiong C, Huang D. | 04/9/2022 |
| The Human RAD5 Homologs, HLTF and SHPRH, Have Separate Functions in DNA Damage Tolerance Dependent on The DNA Lesion Type. | The Human RAD5 Homologs, HLTF and SHPRH, Have Separate Functions in DNA Damage Tolerance Dependent on The DNA Lesion Type.
Seelinger M, Søgaard CK, Otterlei M., Free PMC Article | 03/20/2021 |
| Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA). | Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA).
Seelinger M, Otterlei M., Free PMC Article | 11/21/2020 |
| circ-0001649 regulated behaviors of hepatocellular carcinoma cells by targeting SHPRH; circ-0001649 served as a ceRNA to sponge miR-127-5p, miR-612 and miR-4688, thus activating SHPRH | Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge.
Su Y, Xu C, Liu Y, Hu Y, Wu H., Free PMC Article | 06/20/2020 |
| A novel perspective regarding circRNA function in physiological and pathological processes: specifically, SHPRH-146aa generated from overlapping genetic codes of circ-SHPRH is a tumor suppressor in human glioblastoma. | A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.
Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N. | 03/30/2019 |
| This study suggests that SHPRH could be a link between mTOR-mediated epigenetic regulations and rRNA transcription, while concomitantly affecting genomic integrity. | SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats.
Lee D, Park JH, Kim S, Lee SG, Myung K., Free PMC Article | 11/10/2018 |
| evidence that SHPRH functions in rRNA transcription through its interaction with histone H3 in a mammalian target of rapamycin (mTOR)-dependent manner | SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner.
Lee D, An J, Park YU, Liaw H, Woodgate R, Park JH, Myung K., Free PMC Article | 04/28/2018 |
| HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate. | SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.
Lin JR, Zeman MK, Chen JY, Yee MC, Cimprich KA., Free PMC Article | 06/18/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| HLTF and SHPRH are functional homologues of yeast Rad5 that cooperatively mediate PCNA polyubiquitination and maintain genomic stability. | Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
Motegi A, Liaw HJ, Lee KY, Roest HP, Maas A, Wu X, Moinova H, Markowitz SD, Ding H, Hoeijmakers JH, Myung K., Free PMC Article | 01/21/2010 |
| We report that a putative tumor suppressor gene, SHPRH, is a human orthologue of yeast RAD5.The yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress. | Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.
Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K., Free PMC Article | 01/21/2010 |
| SHPRH maps to 6q24 and is a possible candidate for the tumor suppressor gene reported from that region. | Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region.
Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM. | 01/21/2010 |
| SHPRH function is an important deterrent to mutagenesis and carcinogenesis in humans | Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen.
Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L., Free PMC Article | 01/21/2010 |