Abstract
There are hundreds of copies of rDNA repeats in mammalian chromosomes and the ratio of active, poised, or inactive rDNA is regulated in epigenetic manners. Recent studies demonstrated that a post-DNA replication repair enzyme, SHPRH affects rRNA transcription by recognizing epigenetic markers on rDNA promoters and unveiled potential links between DNA repair and ribosome biogenesis. This study suggests that SHPRH could be a link between mTOR-mediated epigenetic regulations and rRNA transcription, while concomitantly affecting genomic integrity.
Keywords:
SHPRH; mTOR; plant homeodomain; ribosomal RNA; transcription.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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DNA Helicases / chemistry
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DNA Helicases / metabolism*
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DNA, Ribosomal / genetics*
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Epigenesis, Genetic*
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Humans
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Promoter Regions, Genetic
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Protein Domains
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RNA, Ribosomal / genetics*
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TOR Serine-Threonine Kinases / metabolism
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Transcription, Genetic*
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Ubiquitin-Protein Ligases / chemistry
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Ubiquitin-Protein Ligases / metabolism*
Substances
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DNA, Ribosomal
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RNA, Ribosomal
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SHPRH protein, human
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Ubiquitin-Protein Ligases
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TOR Serine-Threonine Kinases
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DNA Helicases
Grants and funding
This work was supported by the Institute for Basic Science (IBS-R022-D1-2017) to K. Myung.