U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    nhsb Nance-Horan syndrome b (congenital cataracts and dental anomalies) [ Danio rerio (zebrafish) ]

    Gene ID: 559636, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nhsbprovided by ZNC
    Official Full Name
    Nance-Horan syndrome b (congenital cataracts and dental anomalies)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090617-2
    See related
    Ensembl:ENSDARG00000079977 AllianceGenome:ZFIN:ZDB-GENE-090617-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nhs
    Summary
    Predicted to be involved in cell differentiation and lens development in camera-type eye. Human ortholog(s) of this gene implicated in Nance-Horan syndrome and cataract 40. Orthologous to human NHS (NHS actin remodeling regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nhsb in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (30000494..30090019)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (29753340..29842835)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch73-226l13.2 Neighboring gene interleukin-1 family member A Neighboring gene angiotensin I converting enzyme 2 Neighboring gene si:ch211-161f7.2 Neighboring gene Scm polycomb group protein like 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. Postlethwait JH, et al. bioRxiv, 2020 Sep 2. PMID 32908984, Free PMC Article
    2. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Nance-Horan syndrome protein
    Names
    Nance-Horan syndrome (congenital cataracts and dental anomalies)
    nance-Horan syndrome protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      30000494..30090019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479857.1 → XP_021335532.1  Nance-Horan syndrome protein isoform X1

      UniProtKB/TrEMBL
      A0A8M9PVJ7
      Conserved Domains (1) summary
      pfam15273
      Location:392 → 1047
      NHS; NHS-like

    2. XM_009306118.3 → XP_009304393.1  Nance-Horan syndrome protein isoform X2

      UniProtKB/TrEMBL
      A0A8M3AXS7
      Conserved Domains (1) summary
      pfam15273
      Location:386 → 1018
      NHS; NHS-like

    3. XM_021479858.1 → XP_021335533.1  Nance-Horan syndrome protein isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q7R9
      Related
      ENSDARP00000154662.1, ENSDART00000189770.1
      Conserved Domains (1) summary
      pfam15273
      Location:377 → 1032
      NHS; NHS-like

    4. XM_009306119.3 → XP_009304394.1  Nance-Horan syndrome protein isoform X3

      UniProtKB/TrEMBL
      A0A8M3BDS0
      Conserved Domains (1) summary
      pfam15273
      Location:385 → 1017
      NHS; NHS-like

    5. XM_009306120.3 → XP_009304395.1  Nance-Horan syndrome protein isoform X5

      UniProtKB/TrEMBL
      A0A8M3AXP9
      Related
      ENSDARP00000145118.1, ENSDART00000191011.1
      Conserved Domains (1) summary
      pfam15273
      Location:371 → 1003
      NHS; NHS-like

    6. XM_021479859.1 → XP_021335534.1  Nance-Horan syndrome protein isoform X6

      UniProtKB/TrEMBL
      A0A8M9QDP4
      Conserved Domains (1) summary
      pfam15273
      Location:356 → 1011
      NHS; NHS-like

    7. XM_021479860.1 → XP_021335535.1  Nance-Horan syndrome protein isoform X7

      UniProtKB/TrEMBL
      A0A8M9QM22
      Related
      ENSDARP00000139009.1, ENSDART00000164139.2
      Conserved Domains (1) summary
      pfam15273
      Location:304 → 959
      NHS; NHS-like
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.