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    CG33514 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346239, updated on 10-May-2024

    Summary

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    Official Symbol
    CG33514provided by FlyBase
    Primary source
    FLYBASE:FBgn0053514
    Locus tag
    Dmel_CG33514
    See related
    AllianceGenome:FB:FBgn0053514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15017; CG15018; Dmel\CG33514
    Summary
    Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein) and TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG33514 in Genome Data Viewer
    Location:
    64B2-64B2; 3-12 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4365434..4366671)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4365434..4366671)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cdc42-interacting protein 4 Neighboring gene long non-coding RNA:CR45156 Neighboring gene mitochondrial ribosomal protein S6 Neighboring gene uncharacterized protein Neighboring gene Dopamine/Ecdysteroid receptor Neighboring gene long non-coding RNA:CR44360 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development. Huang HW, et al. J Cell Sci, 2017 Sep 15. PMID 28775151, Free PMC Article
    2. Abdominal-B neurons control Drosophila virgin female receptivity. Bussell JJ, et al. Curr Biol, 2014 Jul 21. PMID 24998527, Free PMC Article
    3. dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing. Adler PN, et al. Dev Biol, 2013 Jul 1. PMID 23623898, Free PMC Article
    4. Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Choksi SP, et al. Dev Cell, 2006 Dec. PMID 17141154
    5. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG33514-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4365434..4366671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014558.3 → NP_001014558.1  uncharacterized protein Dmel_CG33514 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014558.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLM7
      Conserved Domains (2) summary
      smart01100
      Location:28 → 74
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:97 → 253
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NLM7 Q6NLM7

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