1AUA


Conserved Protein Domain Family
SEC14

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cd00170: SEC14 (this model, PSSM-Id:238099 is obsolete and has been replaced by 469559)
Click on image for an interactive view with Cn3D
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.
Statistics
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PSSM-Id: 238099
Aligned: 109 rows
Threshold Bit Score: 48.1502
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
phospholipidsalt bridge
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:phospholipid binding pocket [chemical binding site]
Evidence:
  • Comment:required for phospholipid transfer activity
  • Citation:PMID 9461221
  • Structure:1AUA, bound n-octyl-beta-D-glucopyranoside
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                              # # #                                #                  
1AUA        97 KPLIAKf--yPQYYHKt--DKDGRPVYFEelgav-nlhemNKVTSe--ERMLKNLVWEYESVVQYRLPacsraaghlvet 169  baker's yeast
AAF47827   310 IEPYKRv--lSHGGYLksgGQNAIVIFCAchlpd-rsradYSYVM---DNLFLYVVKTLEQLVTDDYVli---------y 374  fruit fly
CAB99269     2 EHDLER----LCFIGGydnDNDKVIVVVTknl------elFKKYDd--INLIKEAYNHVHKLIQKDERyt---------a 60   fission yeast
7495872     88 NPIFQKrlmpRGEILEk-tDNQNRLLWYIeyati-tvesiAHSIRs--SEACKFQFLQFEYMLRKVMEqeert--gclss 161  Caenorhabditis e...
AAH05659   166 IEPYKKv--lSHGGYHg-dGLNAVILFAScylp----rssIPNYTyimEHLFRYMVGTLELLVAENYLlv--------hl 230  house mouse
6093506    147 IEPYKKv--iSHGGYYg-dGLNAIVVFAVcfmpe-ssqpnYRYLM---DNLFKYVIGTLELLVAENYMiv---------y 210  human
7511973   1612 KEEFKTlksmNIFYQAg-tSKSGYPVFYYiarr----ykiGETNG---DLLIYHVILTLKPFCHSPFEvv--------id 1675 fruit fly
548350    1581 KEEFKAlktlSIFYQAg-tSKAGNPIFYYvar-----rfkTGQINg--DLLIYHVLLTLKPYYAKPYEi----------v 1642 human
XP_010040  201 ETLVQKvvspYLGTYGl-hSSEGPFTHSCilelqrdkaaaAAVLGavrKRPSVVPMAGQDPALSTSHPfydva--rhgil 277  human
7459614     11 EQLIEKl--eIFKIHGr--DKRGRKILRIigk-----ffpARFLSl--DVLKKYLEEKIFPRLGRKPFav--------ly 71   thale cress
Feature 1          # #                  #   #   #   #  #  # #       #      #           #       
1AUA       170 SCTIMDLKGISissay----svmsyVREASYISQNYYPERMGKFYIINAPf-GFSTAFRLFKPFLDPVTVSKIFIlgssy 244  baker's yeast
AAF47827   375 LHGGSNRRNVPpf----------pwLKRCYQLLDRRLRKSLKHMYLVHPTf-WIKSLVWMARPFVSTKFWRKLVYvksle 443  fruit fly
CAB99269    61 VFFAHDSTVFSyl----------glSLKAYYGMDYYLHKNVKAVYVIHTDw-MSKVAIRTLLSIASPKFTRKFRYlns-- 127  fission yeast
7495872    162 LRHIVNMDGYEinpftmvfvtsgtlAYYSQLFHFENYPELVTPVDMVNIAk-WIHVPYKIAKAMMPTGFSEKFRLhdrhf 240  Caenorhabditis e...
AAH05659   231 SGGTSRAQVPPls-----------wIRQCYRTLDRRLRKNLRALVVVHATw-YVKAFLALVRPFISSKFTRKIRFlds-- 296  house mouse
6093506    211 LNGATTRRKMPsl----------gwLRKCYQQIDRRLRKNLKSLIIVHPSw-FIRTLLAVTRPFISSKFSQKIRYvfnla 279  human
7511973   1676 FTHTCSDNRFRte-----------fLQKWFYVLPTVAYENVHAVYIYNCNswVREYTKFHDRILAPLKGNRKLLFles-- 1742 fruit fly
548350    1643 VDLTHTGPSNRfkt---------dfLSKWFVVFPGFAYDNVSAVYIYNCNs-WVREYTKYHERLLTGLKGSKRLVfidc- 1711 human
XP_010040  278 QVAGDDRFGRRvvtfsc---crmppSHELDHQRLLEYKKNLKALYVVHPTs-FIKVLWNILKPLISHKFGKKVIYfny-- 351  human
7459614     72 VHTGVQRSENFpgi---------saLRAIYDAIPVNVRDNLQEVYFLHPGlqSRLFLATCGRFLFSGGLYGKLRYisr-- 140  thale cress
Feature 1                          
1AUA       245 qkeLLKQIPAENLPVKFGGK 264  baker's yeast
AAF47827   444 elgMHVVVEKAAIPEKVKQY 463  fruit fly
CAB99269   128 isdLNKYIPLSHLKLPPIVY 147  fission yeast
7495872    241 ietLTEDINIDDIPVSLGGN 260  Caenorhabditis elegans
AAH05659   297 lgeLAQLISLEQVHIPEVVR 316  house mouse
6093506    280 elaELVPMEYVGIPECIKQV 299  human
7511973   1743 pnkLTDFIDAEQQKLPGATL 1762 fruit fly
548350    1712 pgkLAEHIEHEQQKLPAATL 1731 human
XP_010040  352 lseLHEHLKYDQLVIPPEVL 371  human
7459614    141 vdyLWEHVRRNEIEMPEFVY 160  thale cress

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