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    znf827 zinc finger protein 827 [ Danio rerio (zebrafish) ]

    Gene ID: 565077, updated on 19-Jun-2024

    Summary

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    Official Symbol
    znf827provided by ZNC
    Official Full Name
    zinc finger protein 827provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080728-3
    See related
    Ensembl:ENSDARG00000076171 AllianceGenome:ZFIN:ZDB-GENE-080728-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-215c3.2
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF827 (zinc finger protein 827). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See znf827 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (36017856..36151591, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (35285833..35420008, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene zgc:152968 Neighboring gene metabolism of cobalamin associated A Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene uncharacterized LOC100538006

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. Postlethwait JH, et al. bioRxiv, 2020 Sep 2. PMID 32908984, Free PMC Article
    2. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 827

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      36017856..36151591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292558.3 → XP_009290833.1  zinc finger protein 827 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ATR1
      Conserved Domains (3) summary
      COG5048
      Location:409 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:430 → 450
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1191 → 1215
      zf-H2C2_2; Zinc-finger double domain

    2. XM_001919166.7 → XP_001919201.4  zinc finger protein 827 isoform X2

      UniProtKB/TrEMBL
      A0A8M1QK95
      Conserved Domains (5) summary
      COG5048
      Location:409 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:430 → 450
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:875 → 895
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05605
      Location:871 → 923
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam13465
      Location:1194 → 1218
      zf-H2C2_2; Zinc-finger double domain

    3. XM_005159977.4 → XP_005160034.1  zinc finger protein 827 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B762
      Conserved Domains (5) summary
      COG5048
      Location:409 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:430 → 450
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:875 → 895
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05605
      Location:871 → 923
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam13465
      Location:1204 → 1228
      zf-H2C2_2; Zinc-finger double domain

    4. XM_005159980.4 → XP_005160037.1  zinc finger protein 827 isoform X4

      See identical proteins and their annotated locations for XP_005160037.1

      UniProtKB/TrEMBL
      A0A8M2B6U3, F1RA62
      Related
      ENSDARP00000154084.1, ENSDART00000182113.1
      Conserved Domains (5) summary
      COG5048
      Location:409 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:430 → 450
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:875 → 895
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05605
      Location:871 → 923
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam13465
      Location:442 → 467
      zf-H2C2_2; Zinc-finger double domain

    5. XM_005159979.4 → XP_005160036.1  zinc finger protein 827 isoform X4

      See identical proteins and their annotated locations for XP_005160036.1

      UniProtKB/TrEMBL
      A0A8M2B6U3, F1RA62
      Related
      ENSDARP00000029203.7, ENSDART00000037516.9
      Conserved Domains (5) summary
      COG5048
      Location:409 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:430 → 450
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:875 → 895
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05605
      Location:871 → 923
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam13465
      Location:442 → 467
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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