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Conserved domains on  [gi|528468464|ref|XP_001919201|]
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zinc finger protein 827 isoform X2 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-Di19 super family cl05267
Drought induced 19 protein (Di19), zinc-binding; This family consists of several drought ...
 871-923 1.89e-04

Drought induced 19 protein (Di19), zinc-binding; This family consists of several drought induced 19 (Di19) like proteins. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought. This domain is a zinc-binding domain.


The actual alignment was detected with superfamily member pfam05605:

Pssm-ID: 428539  Cd Length: 54  Bit Score: 40.36  E-value: 1.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 528468464   871 QLFPCPVCGKVFgRQQTLSRHLSL-HTEERKY-KCHLCpyAAKCRANLNQHLTIH 923
Cdd:pfam05605    1 DEFTCPFCGEDF-DVVSLCEHVEDeHPVESKNvVCPVC--AAKVGKDMIGHLTLQ 52
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1194-1218 5.23e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 5.23e-04
                           10        20
                   ....*....|....*....|....*
gi 528468464  1194 LIEHVRVHTGERPFHCDRCSYSCKR 1218
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
442-467 1.63e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.63e-03
                           10        20
                   ....*....|....*....|....*.
gi 528468464   442 YWKRHMVIHTGLKSHQCPLCPFRCAR 467
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
1179-1203 2.29e-03

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 36.76  E-value: 2.29e-03
                           10        20
                   ....*....|....*....|....*
gi 528468464  1179 YKCEQCGYLSKTANKLIEHVRVHTG 1203
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
 
Name Accession Description Interval E-value
zf-Di19 pfam05605
Drought induced 19 protein (Di19), zinc-binding; This family consists of several drought ...
 871-923 1.89e-04

Drought induced 19 protein (Di19), zinc-binding; This family consists of several drought induced 19 (Di19) like proteins. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought. This domain is a zinc-binding domain.


Pssm-ID: 428539  Cd Length: 54  Bit Score: 40.36  E-value: 1.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 528468464   871 QLFPCPVCGKVFgRQQTLSRHLSL-HTEERKY-KCHLCpyAAKCRANLNQHLTIH 923
Cdd:pfam05605    1 DEFTCPFCGEDF-DVVSLCEHVEDeHPVESKNvVCPVC--AAKVGKDMIGHLTLQ 52
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1194-1218 5.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 5.23e-04
                           10        20
                   ....*....|....*....|....*
gi 528468464  1194 LIEHVRVHTGERPFHCDRCSYSCKR 1218
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
442-467 1.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.63e-03
                           10        20
                   ....*....|....*....|....*.
gi 528468464   442 YWKRHMVIHTGLKSHQCPLCPFRCAR 467
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
1179-1203 2.29e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 36.76  E-value: 2.29e-03
                           10        20
                   ....*....|....*....|....*
gi 528468464  1179 YKCEQCGYLSKTANKLIEHVRVHTG 1203
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
 
Name Accession Description Interval E-value
zf-Di19 pfam05605
Drought induced 19 protein (Di19), zinc-binding; This family consists of several drought ...
 871-923 1.89e-04

Drought induced 19 protein (Di19), zinc-binding; This family consists of several drought induced 19 (Di19) like proteins. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought. This domain is a zinc-binding domain.


Pssm-ID: 428539  Cd Length: 54  Bit Score: 40.36  E-value: 1.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 528468464   871 QLFPCPVCGKVFgRQQTLSRHLSL-HTEERKY-KCHLCpyAAKCRANLNQHLTIH 923
Cdd:pfam05605    1 DEFTCPFCGEDF-DVVSLCEHVEDeHPVESKNvVCPVC--AAKVGKDMIGHLTLQ 52
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1194-1218 5.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 5.23e-04
                           10        20
                   ....*....|....*....|....*
gi 528468464  1194 LIEHVRVHTGERPFHCDRCSYSCKR 1218
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
442-467 1.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.63e-03
                           10        20
                   ....*....|....*....|....*.
gi 528468464   442 YWKRHMVIHTGLKSHQCPLCPFRCAR 467
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
1179-1203 2.29e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 36.76  E-value: 2.29e-03
                           10        20
                   ....*....|....*....|....*
gi 528468464  1179 YKCEQCGYLSKTANKLIEHVRVHTG 1203
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 456-478 4.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 4.21e-03
                           10        20
                   ....*....|....*....|...
gi 528468464   456 HQCPLCPFRCARKDNLKSHMKVH 478
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 873-895 6.30e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 6.30e-03
                           10        20
                   ....*....|....*....|...
gi 528468464   873 FPCPVCGKVFGRQQTLSRHLSLH 895
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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