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    Tnk2 tyrosine kinase, non-receptor, 2 [ Mus musculus (house mouse) ]

    Gene ID: 51789, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tnk2provided by MGI
    Official Full Name
    tyrosine kinase, non-receptor, 2provided by MGI
    Primary source
    MGI:MGI:1858308
    See related
    Ensembl:ENSMUSG00000022791 AllianceGenome:MGI:1858308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ack; Ack1; Pyk1; Ack-1; Cdgip
    Summary
    Enables WW domain binding activity. Involved in spermatid development. Located in several cellular components, including endosome; growth cone; and neuronal cell body. Is active in postsynaptic cytosol and presynaptic cytosol. Is expressed in several structures, including liver; nervous system; retina; submandibular gland primordium; and vibrissa. Orthologous to human TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 54.9), stomach adult (RPKM 35.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnk2 in Genome Data Viewer
    Location:
    16 B3; 16 23.16 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32462699..32502311)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32644099..32683493)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SET domain containing 6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7444 Neighboring gene transferrin receptor Neighboring gene STARR-seq mESC enhancer starr_40668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32651205-32651388 Neighboring gene STARR-seq mESC enhancer starr_40671 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32668208-32668409 Neighboring gene tyrosine kinase, non-receptor 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_40672 Neighboring gene predicted gene, 34766 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Sridaran D, et al. Nat Commun, 2022 Nov 14. PMID 36376335, Free PMC Article
    2. ACK1 Contributes to the Pathogenesis of Inflammation and Autoimmunity by Promoting the Activation of TLR Signaling Pathways. Jing L, et al. Front Immunol, 2022. PMID 35669783, Free PMC Article
    3. Expression pattern of ACK1 tyrosine kinase during brain development in the mouse. La Torre A, et al. Gene Expr Patterns, 2006 Oct. PMID 16750431
    4. ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation. Brandao R, et al. FEBS Open Bio, 2021 Jun. PMID 33730447, Free PMC Article
    5. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Mahajan K, et al. Am J Pathol, 2012 Apr. PMID 22322295, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACK1 Contributes to the Pathogenesis of Inflammation and Autoimmunity by Promoting the Activation of TLR Signaling Pathways.
      Title: ACK1 Contributes to the Pathogenesis of Inflammation and Autoimmunity by Promoting the Activation of TLR Signaling Pathways.
    2. ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation.
      Title: ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation.
    3. miR-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT-MMP2-MMP9 pathway.
      Title: miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT/MMPs pathway.
    4. findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells.
      Title: Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.
    5. that the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic brake that stabilizes DAT at the plasma membrane.
      Title: Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant.
    6. ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation.
      Title: Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation.
    7. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer
      Title: Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.
    8. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
      Title: Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
    9. Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.
      Title: Expression pattern of ACK1 tyrosine kinase during brain development in the mouse.
    10. These studies suggest that ACK1 senses signal of epidermal growth factor (EGF) and regulates ligand-induced degradation of EGFR.
      Title: Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37479

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables WW domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Grb2-EGFR complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoophidium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activated CDC42 kinase 1
    Names
    Cdc42 GTPase-inhibiting protein
    P21cdc42Hs kinase
    non-receptor protein tyrosine kinase ACK
    tyrosine kinase non-receptor protein 2
    NP_001103617.1
    NP_001276372.1
    NP_001334114.1
    NP_058068.2
    XP_006522395.1
    XP_006522396.1
    XP_006522397.1
    XP_006522398.1
    XP_006522399.1
    XP_006522400.1
    XP_006522401.1
    XP_006522402.1
    XP_006522403.1
    XP_006522405.1
    XP_006522406.1
    XP_006522407.1
    XP_011244248.1
    XP_017172554.1
    XP_017172555.1
    XP_030105034.1
    XP_030105035.1
    XP_030105036.1
    XP_036015894.1
    XP_036015895.1
    XP_036015896.1
    XP_036015897.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110147.1 → NP_001103617.1  activated CDC42 kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_001103617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      BC052421
      Consensus CDS
      CCDS49828.1
      UniProtKB/TrEMBL
      A0A0R4J1L0, D3Z3U5
      Related
      ENSMUSP00000110778.2, ENSMUST00000115125.8
      Conserved Domains (7) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:126 → 385
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:959 → 998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:447 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    2. NM_001289443.1 → NP_001276372.1  activated CDC42 kinase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR, lacks part of the 5' coding region, lacks two in-frame exons in the central coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC161755, BB583500, BC052421
      UniProtKB/Swiss-Prot
      O54967
      Conserved Domains (2) summary
      cd14328
      Location:469 → 508
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam11555
      Location:284 → 348
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    3. NM_001347185.1 → NP_001334114.1  activated CDC42 kinase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161755, BC052421
      Consensus CDS
      CCDS84224.1
      UniProtKB/TrEMBL
      D3Z3U7
      Related
      ENSMUSP00000110773.2, ENSMUST00000115120.9

    4. NM_016788.3 → NP_058068.2  activated CDC42 kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_058068.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161755, BQ770866, BU702226, DQ666696
      Consensus CDS
      CCDS37313.1
      UniProtKB/Swiss-Prot
      O54967, Q0Z844, Q8C2U0, Q8K0K4
      UniProtKB/TrEMBL
      G3X9X7
      Related
      ENSMUSP00000110777.2, ENSMUST00000115124.9
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:126 → 385
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:976 → 1019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1006 → 1045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:447 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789 → 853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32462699..32502311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317066.3 → XP_017172555.1  activated CDC42 kinase 1 isoform X14

      UniProtKB/TrEMBL
      D3Z3U5, D3Z3U6
      Related
      ENSMUSP00000110776.2, ENSMUST00000115123.9
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:579 → 957
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:961 → 1004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:991 → 1030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:447 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    2. XM_011245946.1 → XP_011244248.1  activated CDC42 kinase 1 isoform X18

      UniProtKB/Swiss-Prot
      O54967, Q0Z844, Q8C2U0, Q8K0K4
      Conserved Domains (7) summary
      PHA03247
      Location:424 → 802
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:806 → 849
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:836 → 875
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:1 → 217
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:277 → 344
      GTPase_binding; GTPase binding
      pfam11555
      Location:619 → 683
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:225 → 274
      SH3_9; Variant SH3 domain

    3. XM_030249176.1 → XP_030105036.1  activated CDC42 kinase 1 isoform X19

      UniProtKB/TrEMBL
      A0A5F8MQ87
      Conserved Domains (6) summary
      PHA03247
      Location:424 → 802
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:804 → 843
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:1 → 217
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:277 → 344
      GTPase_binding; GTPase binding
      pfam11555
      Location:619 → 683
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:225 → 274
      SH3_9; Variant SH3 domain

    4. XM_006522335.1 → XP_006522398.1  activated CDC42 kinase 1 isoform X4

      UniProtKB/Swiss-Prot
      O54967, Q0Z844, Q8C2U0, Q8K0K4
      Related
      ENSMUSP00000159113.2, ENSMUST00000238891.2
      Conserved Domains (8) summary
      cd09539
      Location:30 → 91
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:618 → 996
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1000 → 1043
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1030 → 1069
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154 → 411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:471 → 538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813 → 877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419 → 468
      SH3_9; Variant SH3 domain

    5. XM_030249174.2 → XP_030105034.1  activated CDC42 kinase 1 isoform X10

      UniProtKB/TrEMBL
      D3Z3U5
      Conserved Domains (8) summary
      cd09539
      Location:30 → 91
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:603 → 981
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:985 → 1028
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1015 → 1054
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154 → 411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:471 → 538
      GTPase_binding; GTPase binding
      pfam11555
      Location:798 → 862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419 → 468
      SH3_9; Variant SH3 domain

    6. XM_036160004.1 → XP_036015897.1  activated CDC42 kinase 1 isoform X17

      UniProtKB/TrEMBL
      A0A5F8MQ87
      Conserved Domains (7) summary
      cd09539
      Location:30 → 91
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:603 → 981
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:983 → 1022
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154 → 411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473 → 538
      GTPase_binding; GTPase binding
      pfam11555
      Location:798 → 862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419 → 468
      SH3_9; Variant SH3 domain

    7. XM_036160001.1 → XP_036015894.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/Swiss-Prot
      O54967, Q0Z844, Q8C2U0, Q8K0K4
      Conserved Domains (8) summary
      cd09539
      Location:30 → 91
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:618 → 996
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1000 → 1043
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1030 → 1069
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154 → 411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473 → 538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813 → 877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419 → 468
      SH3_9; Variant SH3 domain

    8. XM_006522339.1 → XP_006522402.1  activated CDC42 kinase 1 isoform X13

      UniProtKB/TrEMBL
      A0A5F8MQ87
      Conserved Domains (7) summary
      cd09539
      Location:30 → 91
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:618 → 996
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:998 → 1037
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154 → 411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:471 → 538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813 → 877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419 → 468
      SH3_9; Variant SH3 domain

    9. XM_006522332.5 → XP_006522395.1  activated CDC42 kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      O54967, Q0Z844, Q8C2U0, Q8K0K4
      Conserved Domains (8) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:626 → 1004
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1008 → 1051
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1038 → 1077
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821 → 885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    10. XM_006522334.5 → XP_006522397.1  activated CDC42 kinase 1 isoform X3

      UniProtKB/Swiss-Prot
      O54967, Q0Z844, Q8C2U0, Q8K0K4
      Conserved Domains (8) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:626 → 1016
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1005 → 1049
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1036 → 1075
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821 → 885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    11. XM_006522338.5 → XP_006522401.1  activated CDC42 kinase 1 isoform X11

      UniProtKB/TrEMBL
      A0A5F8MQ87
      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:626 → 1004
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:1006 → 1045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821 → 885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    12. XM_006522336.5 → XP_006522399.1  activated CDC42 kinase 1 isoform X6

      UniProtKB/TrEMBL
      A0A5F8MPC4, D3Z3U5
      Related
      ENSMUSP00000158905.2, ENSMUST00000238856.2
      Conserved Domains (8) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:611 → 989
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:993 → 1036
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1023 → 1062
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806 → 870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    13. XM_036160002.1 → XP_036015895.1  activated CDC42 kinase 1 isoform X8

      UniProtKB/TrEMBL
      D3Z3U5
      Conserved Domains (8) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:611 → 1001
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:990 → 1034
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1021 → 1060
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806 → 870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    14. XM_030249175.2 → XP_030105035.1  activated CDC42 kinase 1 isoform X15

      UniProtKB/TrEMBL
      A0A5F8MPM0, A0A5F8MQ87
      Related
      ENSMUSP00000159023.2, ENSMUST00000238806.2
      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:611 → 989
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:991 → 1030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806 → 870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    15. XM_006522333.5 → XP_006522396.1  activated CDC42 kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      O54967, Q0Z844, Q8C2U0, Q8K0K4
      Conserved Domains (8) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:626 → 1004
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1008 → 1051
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1038 → 1077
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821 → 885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    16. XM_036160003.1 → XP_036015896.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F8MQ87
      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:626 → 1004
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:1006 → 1045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821 → 885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    17. XM_017317065.3 → XP_017172554.1  activated CDC42 kinase 1 isoform X7

      UniProtKB/TrEMBL
      D3Z3U5
      Conserved Domains (8) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:611 → 989
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:993 → 1036
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1023 → 1062
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806 → 870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    18. XM_006522337.5 → XP_006522400.1  activated CDC42 kinase 1 isoform X9

      UniProtKB/TrEMBL
      D3Z3U5
      Conserved Domains (8) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:611 → 1001
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:990 → 1034
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1021 → 1060
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806 → 870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    19. XM_006522340.5 → XP_006522403.1  activated CDC42 kinase 1 isoform X16

      UniProtKB/TrEMBL
      A0A5F8MQ87
      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:611 → 989
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:991 → 1030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806 → 870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    20. XM_006522342.5 → XP_006522405.1  activated CDC42 kinase 1 isoform X20

      Conserved Domains (6) summary
      PHA03247
      Location:186 → 565
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:568 → 611
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:598 → 637
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam09027
      Location:39 → 106
      GTPase_binding; GTPase binding
      pfam11555
      Location:381 → 445
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      cl17036
      Location:6 → 36
      SH3; Src Homology 3 domain superfamily

    21. XM_006522344.1 → XP_006522407.1  activated CDC42 kinase 1 isoform X21

      See identical proteins and their annotated locations for XP_006522407.1

      Conserved Domains (5) summary
      PHA03247
      Location:104 → 483
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:486 → 529
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:516 → 555
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam09027
      Location:1 → 24
      GTPase_binding; GTPase binding
      pfam11555
      Location:299 → 363
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    22. XM_006522343.1 → XP_006522406.1  activated CDC42 kinase 1 isoform X21

      See identical proteins and their annotated locations for XP_006522406.1

      Conserved Domains (5) summary
      PHA03247
      Location:104 → 483
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:486 → 529
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:516 → 555
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam09027
      Location:1 → 24
      GTPase_binding; GTPase binding
      pfam11555
      Location:299 → 363
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54967.2 GenPept UniProtKB/Swiss-Prot:O54967

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