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    AGO1 argonaute RISC component 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 475337, updated on 17-Aug-2024

    Summary

    Official Symbol
    AGO1provided by VGNC
    Official Full Name
    argonaute RISC component 1provided by VGNC
    Primary source
    VGNC:VGNC:54192
    See related
    Ensembl:ENSCAFG00845030992
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    EIF2C1
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    Genomic context

    See AGO1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (6394522..6431156, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (6501590..6538192, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (6330625..6367229, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (6247517..6284126, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (6321049..6352856, complement)

    Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene tektin 2 Neighboring gene argonaute RISC catalytic component 3 Neighboring gene uncharacterized LOC119869414 Neighboring gene argonaute RISC component 4 Neighboring gene mitochondrial import inner membrane translocase subunit Tim17-A-like Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial-like Neighboring gene claspin

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    protein argonaute-1
    Names
    argonaute 1, RISC catalytic component
    argonaute RISC catalytic component 1
    eukaryotic translation initiation factor 2C, 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051819.1 Reference ROS_Cfam_1.0

      Range
      6394522..6431156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038687563.1XP_038543491.1  protein argonaute-1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0QY26
      Related
      ENSCAFP00845043317.1, ENSCAFT00845055087.1
      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390815
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    2. XM_038687562.1XP_038543490.1  protein argonaute-1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QY26
      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390818
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    3. XM_038687560.1XP_038543488.1  protein argonaute-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0K8V9
      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398826
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute
    4. XM_038687561.1XP_038543489.1  protein argonaute-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0K8V9
      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398823
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute

    RNA

    1. XR_005437904.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049275.1 Alternate UMICH_Zoey_3.1

      Range
      6247517..6284126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038495571.1XP_038351499.1  protein argonaute-1 isoform X4

      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390815
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    2. XM_038495570.1XP_038351498.1  protein argonaute-1 isoform X3

      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390818
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    3. XM_038495568.1XP_038351496.1  protein argonaute-1 isoform X1

      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398826
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute
    4. XM_038495569.1XP_038351497.1  protein argonaute-1 isoform X2

      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398823
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute

    RNA

    1. XR_005336362.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

      Range
      6321049..6352856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038621796.1XP_038477724.1  protein argonaute-1 isoform X4

      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390815
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    2. XM_038621795.1XP_038477723.1  protein argonaute-1 isoform X3

      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390818
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    3. XM_038621793.1XP_038477721.1  protein argonaute-1 isoform X1

      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398826
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute
    4. XM_038621794.1XP_038477722.1  protein argonaute-1 isoform X2

      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398823
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute

    RNA

    1. XR_005404398.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

      Range
      6330625..6367229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038557923.1XP_038413851.1  protein argonaute-1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0QY26
      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390815
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    2. XM_038557922.1XP_038413850.1  protein argonaute-1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QY26
      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390818
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    3. XM_038557920.1XP_038413848.1  protein argonaute-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0K8V9
      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398826
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute
    4. XM_038557921.1XP_038413849.1  protein argonaute-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0K8V9
      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398823
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute

    RNA

    1. XR_005370173.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      6501590..6538192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_532563.7XP_532563.3  protein argonaute-1 isoform X4

      See identical proteins and their annotated locations for XP_532563.3

      UniProtKB/TrEMBL
      A0A8C0QY26
      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390815
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    2. XM_014119391.3XP_013974866.1  protein argonaute-1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QY26
      Conserved Domains (4) summary
      cd02846
      Location:225345
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:390818
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:174224
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:34164
      ArgoN; N-terminal domain of argonaute
    3. XM_022427851.2XP_022283559.1  protein argonaute-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0K8V9
      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398826
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute
    4. XM_022427852.2XP_022283560.1  protein argonaute-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0K8V9
      Conserved Domains (4) summary
      cd02846
      Location:233353
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:398823
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:182232
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:98172
      ArgoN; N-terminal domain of argonaute

    RNA

    1. XR_002633369.2 RNA Sequence