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    Snx4 sorting nexin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360725, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Snx4provided by RGD
    Official Full Name
    sorting nexin 4provided by RGD
    Primary source
    RGD:1309763
    See related
    EnsemblRapid:ENSRNOG00000001786 AllianceGenome:RGD:1309763
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including endocytic recycling; positive regulation of autophagosome assembly; and positive regulation of histamine secretion by mast cell. Predicted to be located in cytoplasm and membrane. Predicted to be part of SNARE complex and cytoplasmic dynein complex. Predicted to be active in early endosome membrane; plasma membrane; and presynaptic endosome. Orthologous to human SNX4 (sorting nexin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 197.4), Brain (RPKM 166.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx4 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (80965965..81023234, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67460872..67518143, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (70693381..70753620, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 148 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene WAS/WASL-interacting protein family member 1-like Neighboring gene uncharacterized LOC120095666 Neighboring gene uncharacterized LOC134481083 Neighboring gene oxysterol binding protein-like 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. Traer CJ, et al. Nat Cell Biol, 2007 Dec. PMID 17994011
    2. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Sander LE, et al. Eur J Immunol, 2008 Mar. PMID 18253931
    3. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Haft CR, et al. Mol Cell Biol, 1998 Dec. PMID 9819414, Free PMC Article
    4. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. Parks WT, et al. J Biol Chem, 2001 Jun 1. PMID 11279102
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leptin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of histamine secretion by mast cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127550.1 → NP_001121022.1  sorting nexin-4

      See identical proteins and their annotated locations for NP_001121022.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166791
      UniProtKB/TrEMBL
      B2RYI6, E9PU13
      Related
      ENSRNOP00000002432.7, ENSRNOT00000002432.8
      Conserved Domains (3) summary
      cd06864
      Location:58 → 184
      PX_SNX4; The phosphoinositide binding Phox Homology domain of Sorting Nexin 4
      cd07622
      Location:205 → 448
      BAR_SNX4; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 4
      pfam11221
      Location:324 → 398
      Med21; Subunit 21 of Mediator complex

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      80965965..81023234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270646.1 → XP_063126716.1  sorting nexin-4 isoform X3

      Related
      ENSRNOP00000111281.1, ENSRNOT00000144987.1

    2. XM_063270645.1 → XP_063126715.1  sorting nexin-4 isoform X2

    3. XM_063270644.1 → XP_063126714.1  sorting nexin-4 isoform X1

    4. XM_063270647.1 → XP_063126717.1  sorting nexin-4 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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