1YKE


Conserved Protein Domain Family
Med21
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pfam11221: Med21 (this model, PSSM-Id:288119 is obsolete and has been replaced by 463241)
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Subunit 21 of Mediator complex
Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.
Links
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Statistics
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PSSM-Id: 288119
Aligned: 89 rows
Threshold Bit Score: 88.062
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1YKE_B         1 MTDRLTQLQICLDQ---MTEQFCATLNYIDKNHGFERLTvNEPQMSDKHA-------------TV--------------V 50  baker's yeast
XP_006680706   1 -mDRLTQLQECLGK---LTEIFFTSTGVLQRDAPLMSTNpDLPITSWKSE-------------QIetnw----------- 52  Batrachochytriu...
XP_002117348   1 MADRLSQLQDAVNQ---LAQHLCDSVGVLQQSAPLSYFDeFESHDRGLLSiqwmqtnqilysnTVsylav-----hnptT 72  Trichoplax adha...
CBY42024       1 MSDRLSQLQDFVND---LAIHMCNSIGVLHESAPTSSFDdAETRTTTPRP-------------DAaef----------ga 54  Oikopleura dioica
XP_002432986   1 MADRLTQLQDTINLnavQAENFCNSIGILQQFAQPGKFSgFERSGSqtp----------------------------qqG 52  human body louse
XP_004348835  70 qTDRLTQLQDRISQ---MAEMLFTSVGVLKDFRPTDAASqTATILPAGAP-------------APsgm------------ 121 Capsaspora owcz...
XP_002945930   2 sSDLLTELQRQLRD---VNDQFAIVIEQLIHIAPPAPLEgDSGQIVAEEP-------------SAvs------------- 52  Volvox carteri ...
XP_004995796   1 MGDRVTQLQELLQA---LMEHYRNAVGVLHMQAGEAAMEpAPSSAKKQPQ-------------KQpqkqqnngeegavaS 64  Salpingoeca ros...
CDJ00787       1 MADRLTELQDAINL---QAENLGNAVGVIQQLAQPSLFReLNHNG-RREK-------------EWasnpe-----fqalL 58  Echinococcus mu...
XP_002370903  15 aADPVTRLQQLLTN---FSRHLYDVVQQVPELAPPLPLSpTD-SSSSSAS-------------SSsaspa-----sgeaE 72  Toxoplasma gond...

1YKE_B        51 PPEEFSNTIDELSTDIILKTRQINKLIDSLPGVDVSAEEQLRKIDMLQKKLVEVEDEKIEAIKKK-EKLLRHVDSLIEDF 129 baker's yeast
XP_006680706  53 --lanKDLAKTAAKDIVETAKVIDFLIDQLPGISENEEEQIRILGALEEENRIAGIEMEQAIEEA-EKLRGEIQTSLRRI 129 Batrachochytriu...
XP_002117348  73 NGENVENNLDVFATLITRTAQDIDYIITSLPDIRVSQQNQEKAIERLQEENAQARQQLVEAITRA-EGVLLKVKQIKNQV 151 Trichoplax adha...
CBY42024      55 QKTESRRNIELFSSLITRTFKNIDTLIDSLPSEESTSSLQAATLQKIQTENQAEAERLRSFVEKG-EKIHDRIQAALDDI 133 Oikopleura dioica
XP_002432986  53 NQQAQEDYAQLFATLIARCAKDIDVLIESLPNEDSSTELQVASLRRLETENQEAADRLEQVVKKG-ELLLEQIQSALADI 131 human body louse
XP_004348835 122 slQQYEEFAQTHASMIARTAKEIDVLIDSLPEMHVDAEDELQMFANLHKQNADAGIAFGETVNLA-EAHLTAVKQALHFV 200 Capsaspora owcz...
XP_002945930  53 -haELQVKALELSKGIAQRFKDINTIISKLPDAYEPPEKQDARIGVLLHEHHALRKELGLVMQEA-ERKLEEIHGCYEAI 130 Volvox carteri ...
XP_004995796  65 ARQQVQQTVDVTKHAILQTVKDINLFCDHLPDIKQATNTNDDDLDELHRKNAEAASLLRTKVQLA-EERLALLRGRITDI 143 Salpingoeca ros...
CDJ00787      59 QSQSQEDNAHKFAVTIATTAKQIELLINSLPAEEASLELQDEVTRQLLSDYRKESAKLVHLITKSfQTRLSKVRQLLSKI 138 Echinococcus mu...
XP_002370903  73 KRSQVESFLLRSANNVAAIMHAIETEIGNLPSSLRTREETQRRIAFLEKENDRAAKELQAVAAEA-TRVREALRQLLRhs 151 Toxoplasma gond...

1YKE_B       130 VD 131 baker's yeast
XP_006680706 130 AD 131 Batrachochytrium dendrobatidis JAM81
XP_002117348 152 Aa 153 Trichoplax adhaerens
CBY42024     134 AD 135 Oikopleura dioica
XP_002432986 132 AQ 133 human body louse
XP_004348835 201 As 202 Capsaspora owczarzaki ATCC 30864
XP_002945930 131 AQ 132 Volvox carteri f. nagariensis
XP_004995796 144 TN 145 Salpingoeca rosetta
CDJ00787     139 Ae 140 Echinococcus multilocularis
XP_002370903 152 it 153 Toxoplasma gondii ME49
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