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    Pdia5 protein disulfide isomerase family A, member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360722, updated on 2-Nov-2024

    Summary

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    Symbol
    Pdia5provided by RGD
    Full Name
    protein disulfide isomerase family A, member 5provided by RGD
    Primary source
    RGD:1359236
    See related
    EnsemblRapid:ENSRNOG00000032327 AllianceGenome:RGD:1359236
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human PDIA5 (protein disulfide isomerase family A member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 130.4), Testes (RPKM 72.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pdia5 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78777436..78892370)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (65272152..65359087)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (68493035..68578999)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene semaphorin 5B Neighboring gene uncharacterized LOC120095662 Neighboring gene uncharacterized LOC120095661 Neighboring gene uncharacterized LOC120095660 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene uncharacterized LOC102551038 Neighboring gene adenylate cyclase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family. Alanen HI, et al. Antioxid Redox Signal, 2006 Mar-Apr. PMID 16677074
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide-isomerase A5
    Names
    protein disulfide isomerase-associated 5
    protein disulfide-isomerase A5-like
    NP_001014147.1
    XP_038944423.1
    XP_038944424.1
    XP_063126712.1
    XP_063126713.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014125.1 → NP_001014147.1  protein disulfide-isomerase A5 precursor

      See identical proteins and their annotated locations for NP_001014147.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088305
      UniProtKB/Swiss-Prot
      Q5I0H9
      Related
      ENSRNOP00000059945.3, ENSRNOT00000067984.3
      Conserved Domains (3) summary
      cd02997
      Location:396 → 499
      PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
      cd03067
      Location:26 → 137
      PDI_b_PDIR_N; PDIb family, PDIR subfamily, N-terminal TRX-like b domain; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. ...
      TIGR01130
      Location:166 → 501
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      78777436..78892370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270642.1 → XP_063126712.1  protein disulfide-isomerase A5 isoform X1

    2. XM_039088496.2 → XP_038944424.1  protein disulfide-isomerase A5 isoform X3

      UniProtKB/TrEMBL
      A6IRG4
      Conserved Domains (3) summary
      cd02997
      Location:150 → 254
      PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
      cd03067
      Location:26 → 137
      PDI_b_PDIR_N; PDIb family, PDIR subfamily, N-terminal TRX-like b domain; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. ...
      cl00388
      Location:275 → 323
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. XM_039088495.2 → XP_038944423.1  protein disulfide-isomerase A5 isoform X2

      Conserved Domains (2) summary
      cd02997
      Location:302 → 405
      PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
      cl00388
      Location:1 → 43
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    4. XM_063270643.1 → XP_063126713.1  protein disulfide-isomerase A5 isoform X2

    RNA

    1. XR_005491040.2 RNA Sequence

    2. XR_005491041.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0H9.1 GenPept UniProtKB/Swiss-Prot:Q5I0H9

    Gene LinkOut

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