2B5E


Conserved Protein Domain Family
ER_PDI_fam

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TIGR01130: ER_PDI_fam 
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protein disulfide isomerase, eukaryotic
This model represents eukaryotic protein disulfide isomerases retained in the endoplasmic reticulum (ER) and closely related forms. Some members have been assigned alternative or additional functions such as prolyl 4-hydroxylase and dolichyl-diphosphooligosaccharide-protein glycotransferase. Members of this family have at least two protein-disulfide domains, each similar to thioredoxin but with the redox-active disulfide in the motif PWCGHCK, and an ER retention signal at the extreme C-terminus (KDEL, HDEL, and similar motifs).
Statistics
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PSSM-Id: 273457
Aligned: 16 rows
Threshold Bit Score: 545.81
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2B5E_A    14 SAVVKLATDSFNEYIQSHDLVLAEFFAPWCGHCKNMAPEYVKAAETLVEKN--ITLAQIDCTEN--QDLCMEHNIPGFPS 89  baker's yeast
AAA35169  32 SAVVKLATDSFNEYIQSHDLVLAEFFAPWCGHCKNMAPEYVKAAETLVEKN--VTLAQIDCTEN--QDLCMEHNIPGFPS 107 baker's yeast
P55059    21 SDVVQLKKDTFDDFIKTNDLVLAEFFAPWCGHCKALAPEYEEAATTLKEKN--IKLAKVDCTEE--TDLCQQHGVEGYPT 96  Humicola insolens
Q10057    22 AEVPKVNKEGLNELITADKVLMVKFYAPWCGHCKALAPEYESAADELEKDG--ISLVEVDCTEE--GDLCSEYSIRGYPT 97  Schizosaccharomyces...
P80284    38 EAVLTLHADNFDDAIGQHPFILVEFYAPWCGHCKSLAPEYEKAAQLLSKHDpaIVLAKVDANDEknKPLAGKYEVQGFPT 117 Hordeum vulgare
AAC49896  49 VDVTVVTVKNWDETVKKSKFALVEFYAPWCGHCKTLKPEYAKAATALKAAApdALIAKVDATQE--ESLAQKFGVQGYPT 126 Chlamydomonas reinh...
CAB40200  23 ENVLVLTESNFEETINGNEFVLVKFYAPWCGHCKSLAPKYDEAADILKEEGsdIKLAKVDATEN--QALASKFEVRGYPT 100 Caenorhabditis brig...
AAA57472  25 EDVAVLTDAAFADYVAENEFVLVEFYAPWCGHCKSLAPQYSIAAKTLKDSGssIKLAKVDATVE--TQLPGKYGVRGYPT 102 purple sea urchin
Q13087    42 DGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESmvVTLAKVDGPAQ--RELAEEFGVTEYPT 119 human
BAB09837 103 KDVVVIKERNFTDVIENNQYVLVEFYAPWCGHCQSLAPEYAAAATELKEDG--VVLAKIDATEE--NELAQEYRVQGFPT 178 thale cress
2B5E_A    90 LKIFKnSDvnnsIDYEGPRTAEAIVQFMIKQSQPAVavv---adlPaYLAN-EtFVTPVIVQSgkiDADFNATFYSMANK 165 baker's yeast
AAA35169 108 LKIFKnSDvnnsIDYEGPRTAEAIVQFMIKQSQPASava----dlPaYLANeT-FVTPVIVQSgeiDADFNATFYSMANK 182 baker's yeast
P55059    97 LKVFR-GLdn-vSPYKGQRKAAAITSYMIKQSLPAVsevt-kdnlEeFKKAdK-AVLVAYVDAs--DKASSEVFTQVAEK 170 Humicola insolens
Q10057    98 LNVFKnGKq--iSQYSGPRKHDALVKYMRKQLLPTVkpis-kdtlEnFVEKaD-DLAVVAFFK---DQKLNDTYTEVAEV 170 Schizosaccharomyces...
P80284   118 LKIFRnGGks-iQEYKGPREAEGIVEYLKKQVGPASkeikapedaTyLEDG---KIHIVGVFTe-fSGPEFTNFLEVAEK 192 Hordeum vulgare
AAC49896 127 LKWFVdGEl--aSDYNGPRDADGIVGWVKKKTGPPAvtvedadklKsLEAD-A-EVVVVGYFKa-lEGEIYDTFKSYAAK 201 Chlamydomonas reinh...
CAB40200 101 ILYFKsGKp---TKYTGGRATAQIVDWVKKKSGPTVttvetaeqlNeLKSK-N-RVVVLGYFKd-aKSEAATIFNEVADS 174 Caenorhabditis brig...
AAA57472 103 LKFFRsGKd---SEYAGGRTGPEIVAWLNKKTGPPAatiasvedaEaFLAD-K-EVAVIGFFKd-vP----QTFLDVAVN 172 purple sea urchin
Q13087   120 LKFFRnGNrthpEEYTGPRDAEGIAEWLRRRVGPSAmrledeaaaQaLIGG-R-DLVVIGFFQd-lQDEDVATFLALAQD 196 human
BAB09837 179 LLFFVdGEh---KPYTGGRTKETIVTWVKKKIGPGVynlttlddaEkVLTS-G-NKVVLGYLNs-lVGVEHDQLNAASKA 252 thale cress
2B5E_A   166 HFNDYDFVSAENADDDFKLSIYLPsamDEPVVYNGKK-------------ADIAdaDVFEKWLQVEALPYFGEIDGSVFA 232 baker's yeast
AAA35169 183 HFNDYDFVSAENADDDFKLSIYLP------SAMDEPVvyn-------gkkADIAdvDVFEKWLQVEALPYFGEIDGSVFA 249 baker's yeast
P55059   171 LRDNYPFGSSSDAALAEAEGVKAP------AIVLYKDfdeg-----kavfSEKFevEAIEKFAKTGATPLIGEIGPETYS 239 Humicola insolens
Q10057   171 MKDDFVFAASDDKELAKSLGSNFP---GIVAFTKDAAqdsd-----klvyTGDWdpASIADFIGVSSIPLLDELNQMTFG 242 Schizosaccharomyces...
P80284   193 LRSYYD-FGHTVHANHLPRG-------DAA--VERPVvrlfkpfdelvvdSKDFdvSALEKFIDASSTPKVVIFDKNPDN 262 Hordeum vulgare
AAC49896 202 TEDVVFVQTTSADVAKAAGLDAVD---TVSVVKNFAGedrat---avlatDIDT--DSLTAFVKSEKMPPTIEFNQKNSD 273 Chlamydomonas reinh...
CAB40200 175 VDDIFFAVAGSADVAASATLEADG---VSLIRTDGDDsetnt----ivesEITNs-VTLKQWIHAYKLSPVTEFTHDSAQ 246 Caenorhabditis brig...
AAA57472 173 IDDIPFAIVS--DDAVISNYEAKD---GSIILFKKFDegkn-----vfegELTs--EDLTSFVRKNSLSVVTEFGEETAS 240 purple sea urchin
Q13087   197 ALDMTFGLTD--RPRLFQQFGLTK---DTVVLFKKFDegrad---fpvdeELGLdlGDLSRFLVTHSMRLVTEFNSQTSA 268 human
BAB09837 253 EDDVNFYQTVNPDVAKMFHLDPES---KRPALVLVKKeeeki---shfdgEFVK--SALVSFVSANKLALVSVFTRETAP 324 thale cress
2B5E_A   233 QYVESGlPLGYLFYNDEEEL-------EEYKPLFTELAKKNr---gLMnFVSIDARKFGRHAGNLNMK-EqFPLFAIHDM 301 baker's yeast
AAA35169 250 QYVESGlPLGYLFYNDEEEL-------EEYKPLFTELAKKNr---gLMnFVSIDARKFGRHAGNLNMK-EqFPLFAIHDM 318 baker's yeast
P55059   240 DYMSAGiPLAYIFAETAEER-------KELSDKLKPIAEAQr---gVInFGTIDAKAFGAHAGNLNLKtDkFPAFAIQEV 309 Humicola insolens
Q10057   243 KYQQSGlPLGIIFYNSTESR-------DELYDVFQPLAKKYq---dTLrFAFLDAVRYGAVAKQMNVE-SdWPAFVIANL 311 Schizosaccharomyces...
P80284   263 HPYLLK-FFQSNAPKAMLFLnfstgpfESFKSAYYGAVEEFsg--kDVkFLIGDIESSQGAFQYFGLKvDqAPLILIQDG 339 Hordeum vulgare
AAC49896 274 KIFNSG-INKQLILWTTADDlk---adAEIMTVFREASKKFkgqlvFVtVNNEG-DGADPVTNFFGLKgAtSPVLLGFFM 348 Chlamydomonas reinh...
CAB40200 247 EIVGGD-LKKFHFLIIRKSDss----fDETIAKFTEVAKLFrakviFVlLDVDVEE-NGRILEFLGVDaKkTPANRIVSL 320 Caenorhabditis brig...
AAA57472 241 KIFGGE-IKIHNLLFVKKDSdd----fKTIYDQFYAAATTFkgevlFVlIDAAAES-NSRILEYFGLGdEeVPTVRLITL 314 purple sea urchin
Q13087   269 KIFAAR-ILNHLLLFVNQTLaa----hRELLAGFGEAAPRFrgqvlFVvVDVAAD--NEHVLQYFGLKaEaAPTLRLVNL 341 human
BAB09837 325 EIFESA-IKKQLLLFVTKNEs------EKVLTEFQEAAKSFkgkliFVsVDLDNEDYGKPVAEYFGVSgN-GPKLIGYTG 396 thale cress
2B5E_A   302 TE-DLKYGLPQlseeafdELSdkivl-----eskaIESLVKDFLKGDASPIVKSQEIFEN-QDSsVFQLVGKNHDEIVND 374 baker's yeast
AAA35169 319 TE-DLKYGLPQl-----sEEAfdelsdkivleskaIESLVKDFLKGDASPIVKSQEIFEN-QDSsVFQLVGKNHDEIVND 391 baker's yeast
P55059   310 AK-NQKFPFDQe-----kEITfe-----------aIKAFVDDFVAGKIEPSIKSEPIPEK-QEGpVTVVVAKNYNEIVLD 371 Humicola insolens
Q10057   312 KS-MLKYPFPTt-----eLTAk------------aMTKFVGDFVDGKLQPKIKSQPIPES-QED-LVVLVADNFDDIVMD 371 Schizosaccharomyces...
P80284   340 DS--KKFLKEHv------EAGq-------------IVAWLKDYFDGKLTPFRKSEPIPEA-NNEpVKVVVADNVHDVVFK 397 Hordeum vulgare
AAC49896 349 EKn-KKFRMEG-------EFTad-----------nVAKFAESVVDGTAQAVLKSEAIPEDpYEDgVYKIVGKTVESVVLD 409 Chlamydomonas reinh...
CAB40200 321 ADqVEKFKP----------QDge-----------dYEAFTNSYLDGKSTQDLKAQDLPEDwDSQpVKVLVASNFNEIALD 379 Caenorhabditis brig...
AAA57472 315 DGdMKKYKPTv------pELTte-----------sLSQFVIDFKDGKLKPHLMSESVPEDwNANpVTILVGENFAEVALD 377 purple sea urchin
Q13087   342 ET-TKKYAPVDg-----gPVTaa-----------sITAFCHAVLNGQVKPYLLSQEIPPDwDQRpVKTLVGKNFEQVAFD 404 human
BAB09837 397 NEdPKKYFFDG-------EIQsd-----------kIKIFGEDFLNDKLKPFYKSDPIPEKnDED-VKIVVGDNFDEIVLD 457 thale cress
2B5E_A   375 PKKDVLVLYYAPWCGHCKRLAPTYQELADTYANa--TsDVLIAKLDHTENDVRG-VVIEGYPTIVLYPGGKKs-ESVVYQ 450 baker's yeast
AAA35169 392 PKKDVLVLYYAPWCGHCKRLAPTYQELADTYANa--TsDVLIAKLDHTENDVRG-VVIEGYPTIVLYPSGKKs-ESVVYQ 467 baker's yeast
P55059   372 DTKDVLIEFYAPWCGHCKALAPKYEELGALYAKsefKdRVVIAKVDATANDVP--DEIQGFPTIKLYPAGAKg-QPVTYS 448 Humicola insolens
Q10057   372 ETKDVLVEFYAPWCGHCKNLAPTYEKLAEEYSD---DsNVVVAKIDATENDIS--VSISGFPTIMFFKANDKv-NPVRYE 445 Schizosaccharomyces...
P80284   398 SGKNVLIEFYAPWCGHCKKLAPILDEAAATLQS---EeDVVIAKMDATENDVPGeFDVQGYPTLYFVTPSGKk---VSYE 471 Hordeum vulgare
AAC49896 410 ETKDVLLEVYAPWCGHCKKLEPIYKKLAKRFKKv--D-SVIIAKMDGTENEHPE-IEVKGFPTILFYPAGSDrtPIVFEG 485 Chlamydomonas reinh...
CAB40200 380 ESKTVFVKFYAPWCGHCKQLVPVWDELAEKYESn--P-NVVIAKLDATLNELAD-IKVNSFPTLKLWPAGSS--TPVDYD 453 Caenorhabditis brig...
AAA57472 378 PTKDVLVEFYAPWCGHCKQLAPIYEELGEHFKEr--E-DVVIAKVDSTKNEVED-AVVRSFPTLKFWKKGEN--EMVDYS 451 purple sea urchin
Q13087   405 ETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDh--E-DIIIAELDATANELDA-FAVHGFPTLKYFPAGPGr-KVIEYK 479 human
BAB09837 458 DSKDVLLEVYAPWCGHCQALEPMYNKLAKHLRSi--D-SLVITKMDGTTNEHPK-AKAEGFPTILFFPAGNKtsEPITVD 533 thale cress
2B5E_A   451 GSRSLDSLFDFIKENGHFD 469 baker's yeast
AAA35169 468 GSRSLDSLFDFIKENGHFD 486 baker's yeast
P55059   449 GSRTVEDLIKFIAENGKYk 467 Humicola insolens
Q10057   446 GDRTLEDLSAFIDKHASFe 464 Schizosaccharomyces pombe 972h-
P80284   472 GGRTADEIVDYIRKNKETA 490 Hordeum vulgare
AAC49896 486 GDRSLKSLTKFIKTNAKIP 504 Chlamydomonas reinhardtii
CAB40200 454 GDRNLEKFEEFVNKYAGse 472 Caenorhabditis briggsae
AAA57472 452 GDRTLEAMIQFVESGGEII 470 purple sea urchin
Q13087   480 STRDLETFSKFLDNGGVLP 498 human
BAB09837 534 TDRTVVAFYKFLRKHATIP 552 thale cress
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