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    Elf3 E74 like ETS transcription factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304815, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Elf3provided by RGD
    Official Full Name
    E74 like ETS transcription factor 3provided by RGD
    Primary source
    RGD:1310687
    See related
    Ensembl:ENSRNOG00000006330 AllianceGenome:RGD:1310687
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including inflammatory response; mammary gland involution; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including blastocyst development; extracellular matrix organization; and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ELF3 (E74 like ETS transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 151.8), Uterus (RPKM 135.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elf3 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49242265..49247102, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46690460..46695394, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52083873..52088798, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor like GTPase 8A Neighboring gene G protein-coupled receptor 37-like 1 Neighboring gene arginyl aminopeptidase Neighboring gene translocase of inner mitochondrial membrane 17A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. Brembeck FH, et al. Oncogene, 2000 Apr 6. PMID 10773884
    2. The epithelium-specific ets transcription factor ESX is associated with mammary gland development and involution. Neve R, et al. FASEB J, 1998 Nov. PMID 9806763
    3. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. Oettgen P, et al. Mol Cell Biol, 1997 Aug. PMID 9234700, Free PMC Article
    4. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. Brown C, et al. J Biol Chem, 2004 Mar 26. PMID 14715662
    5. Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1. Kim JH, et al. J Biol Chem, 2002 May 17. PMID 11893733

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression.
      Title: High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anatomical structure morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blastocyst development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mammary gland involution IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mammary gland involution ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ETS-related transcription factor Elf-3
    Names
    E74-like factor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024768.1 → NP_001019939.1  ETS-related transcription factor Elf-3

      See identical proteins and their annotated locations for NP_001019939.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097980
      UniProtKB/Swiss-Prot
      Q4V7E1
      Conserved Domains (2) summary
      cd08537
      Location:78 → 155
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
      smart00413
      Location:296 → 383
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      49242265..49247102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249883.5 → XP_006249945.1  ETS-related transcription factor Elf-3 isoform X4

      See identical proteins and their annotated locations for XP_006249945.1

      UniProtKB/TrEMBL
      A6ICE5
      Conserved Domains (2) summary
      cd08537
      Location:52 → 131
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
      smart00413
      Location:272 → 359
      ETS; erythroblast transformation specific domain

    2. XM_063272305.1 → XP_063128375.1  ETS-related transcription factor Elf-3 isoform X5

    3. XM_063272304.1 → XP_063128374.1  ETS-related transcription factor Elf-3 isoform X3

    4. XM_006249881.5 → XP_006249943.1  ETS-related transcription factor Elf-3 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q3H0
      Related
      ENSRNOP00000008753.5
      Conserved Domains (2) summary
      cd08537
      Location:77 → 154
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
      smart00413
      Location:295 → 382
      ETS; erythroblast transformation specific domain

    5. XM_017598796.3 → XP_017454285.1  ETS-related transcription factor Elf-3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7E1.1 GenPept UniProtKB/Swiss-Prot:Q4V7E1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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