ETS-related transcription factor Elf-3 [Rattus norvegicus]
SAM domain-containing protein( domain architecture ID 10170775)
SAM (sterile alpha motif) domain-containing protein may be involved in protein-protein interaction and in developmental regulation
List of domain hits
Name | Accession | Description | Interval | E-value | |||
ETS | smart00413 | erythroblast transformation specific domain; variation of the helix-turn-helix motif |
296-383 | 1.36e-43 | |||
erythroblast transformation specific domain; variation of the helix-turn-helix motif : Pssm-ID: 197710 Cd Length: 87 Bit Score: 146.64 E-value: 1.36e-43
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SAM_PNT-ESE-1-like | cd08537 | Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM ... |
78-155 | 6.90e-43 | |||
Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM Pointed domain of ESE-1-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. SAM Pointed domain of ESE-1 provides a potential docking site for signaling kinase Pak1 in humans. ESE-1 factors are involved in regulation of gene expression in different types of epithelial cells. ESE-1 is expressed in many different organs including intestine, stomach, pancreas, lungs, kidneys, and prostate. The DNA binding consensus motif for ESE-1 consists of a purine-rich GGA[AT] core sequence. The expression profile of these factors is altered in epithelial cancers if compared to normal tissues. Members of this subfamily are potential targets for cancer therapy. : Pssm-ID: 188880 Cd Length: 81 Bit Score: 144.60 E-value: 6.90e-43
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Name | Accession | Description | Interval | E-value | |||
ETS | smart00413 | erythroblast transformation specific domain; variation of the helix-turn-helix motif |
296-383 | 1.36e-43 | |||
erythroblast transformation specific domain; variation of the helix-turn-helix motif Pssm-ID: 197710 Cd Length: 87 Bit Score: 146.64 E-value: 1.36e-43
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SAM_PNT-ESE-1-like | cd08537 | Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM ... |
78-155 | 6.90e-43 | |||
Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM Pointed domain of ESE-1-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. SAM Pointed domain of ESE-1 provides a potential docking site for signaling kinase Pak1 in humans. ESE-1 factors are involved in regulation of gene expression in different types of epithelial cells. ESE-1 is expressed in many different organs including intestine, stomach, pancreas, lungs, kidneys, and prostate. The DNA binding consensus motif for ESE-1 consists of a purine-rich GGA[AT] core sequence. The expression profile of these factors is altered in epithelial cancers if compared to normal tissues. Members of this subfamily are potential targets for cancer therapy. Pssm-ID: 188880 Cd Length: 81 Bit Score: 144.60 E-value: 6.90e-43
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Ets | pfam00178 | Ets-domain; |
298-378 | 3.05e-37 | |||
Ets-domain; Pssm-ID: 459700 Cd Length: 80 Bit Score: 129.54 E-value: 3.05e-37
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SAM_PNT | pfam02198 | Sterile alpha motif (SAM)/Pointed domain; |
71-155 | 4.35e-26 | |||
Sterile alpha motif (SAM)/Pointed domain; Pssm-ID: 460486 Cd Length: 83 Bit Score: 100.05 E-value: 4.35e-26
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SAM_PNT | smart00251 | SAM / Pointed domain; A subfamily of the SAM domain |
71-154 | 1.10e-23 | |||
SAM / Pointed domain; A subfamily of the SAM domain Pssm-ID: 128547 Cd Length: 82 Bit Score: 93.48 E-value: 1.10e-23
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Name | Accession | Description | Interval | E-value | |||
ETS | smart00413 | erythroblast transformation specific domain; variation of the helix-turn-helix motif |
296-383 | 1.36e-43 | |||
erythroblast transformation specific domain; variation of the helix-turn-helix motif Pssm-ID: 197710 Cd Length: 87 Bit Score: 146.64 E-value: 1.36e-43
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SAM_PNT-ESE-1-like | cd08537 | Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM ... |
78-155 | 6.90e-43 | |||
Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM Pointed domain of ESE-1-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. SAM Pointed domain of ESE-1 provides a potential docking site for signaling kinase Pak1 in humans. ESE-1 factors are involved in regulation of gene expression in different types of epithelial cells. ESE-1 is expressed in many different organs including intestine, stomach, pancreas, lungs, kidneys, and prostate. The DNA binding consensus motif for ESE-1 consists of a purine-rich GGA[AT] core sequence. The expression profile of these factors is altered in epithelial cancers if compared to normal tissues. Members of this subfamily are potential targets for cancer therapy. Pssm-ID: 188880 Cd Length: 81 Bit Score: 144.60 E-value: 6.90e-43
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Ets | pfam00178 | Ets-domain; |
298-378 | 3.05e-37 | |||
Ets-domain; Pssm-ID: 459700 Cd Length: 80 Bit Score: 129.54 E-value: 3.05e-37
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SAM_PNT | pfam02198 | Sterile alpha motif (SAM)/Pointed domain; |
71-155 | 4.35e-26 | |||
Sterile alpha motif (SAM)/Pointed domain; Pssm-ID: 460486 Cd Length: 83 Bit Score: 100.05 E-value: 4.35e-26
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SAM_PNT_ESE | cd08757 | Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM ... |
87-153 | 9.80e-26 | |||
Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM Pointed domain of ESE-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. ETS factors are important for cell differentiation. They can be involved in regulation of gene expression in different types of epithelial cells. They are expressed in salivary gland, intestine, stomach, pancreas, lungs, kidneys, colon, mammary gland, and prostate. Members of this group are proto-oncogenes. Expression profiles of these factors are altered in epithelial cancers, which makes them potential targets for cancer therapy. Pssm-ID: 188885 Cd Length: 69 Bit Score: 98.56 E-value: 9.80e-26
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SAM_PNT | smart00251 | SAM / Pointed domain; A subfamily of the SAM domain |
71-154 | 1.10e-23 | |||
SAM / Pointed domain; A subfamily of the SAM domain Pssm-ID: 128547 Cd Length: 82 Bit Score: 93.48 E-value: 1.10e-23
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SAM_PNT | cd08203 | Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in ... |
87-153 | 1.41e-17 | |||
Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in about 40% of transcriptional regulators of ETS family (initially named for Erythroblastosis virus, E26-E Twenty Six). SAM Pointed domain containing proteins of this family additionally have a C-terminal ETS DNA-binding domain. In a few cases, SAM Pointed domain appears as a single domain protein. Members of this group are mostly involved in regulation of embryonic development and growth control in eukaryotes. SAM Pointed domains mediate protein-protein interactions. Depending on the subgroup, they can interact with other SAM Pointed domains forming homo or hetero dimers/oligomers and/or they can recruit a protein kinase to its target which can be a SAM Pointed domain containing protein itself or another protein that has no kinase docking site. Thus, SAM Pointed domains participate in transcriptional regulation and signal transduction. Some genes coding ETS family transcriptional regulators are proto-oncogenes. They are prone to chromosomal translocations resulting in gene fusions. Chimeric proteins with SAM Pointed domains were found in a number of different human tumors including myeloid leukemia, lymphoblastic leukemia, Ewing's sarcoma and primitive neuroectodermal tumor. Members of this family are potential targets for cancer therapy. Pssm-ID: 188876 Cd Length: 67 Bit Score: 76.21 E-value: 1.41e-17
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SAM_PNT-ESE-3-like | cd08539 | Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM ... |
82-151 | 2.59e-12 | |||
Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM Pointed domain of ESE-3-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. The ESE-3 transcriptional activator is involved in regulation of glandular epithelium differentiation through the MAP kinase signaling cascade. It is found to be expressed in glandular epithelium of prostate, pancreas, salivary gland, and trachea. Additionally, ESE-3 is differentially expressed during monocyte-derived dendritic cells development. DNA binding consensus motif for ESE-3 consists of purine-rich GGAA/T core sequence. The expression profiles of these factors are altered in epithelial cancers. Members of this subfamily are potential targets for cancer therapy. Pssm-ID: 188882 Cd Length: 78 Bit Score: 61.97 E-value: 2.59e-12
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SAM_PNT-ESE-2-like | cd08538 | Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators; SAM ... |
82-151 | 3.37e-08 | |||
Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators; SAM Pointed domain of ESE-2-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. ESE-2 factors are involved in regulation of gene expression in a variety of epithelial (glandular and secretory) cells. ESE-2 mRNA was found in skin keratinocytes, salivary gland, mammary gland, stomach, prostate, and kidneys. The DNA binding consensus motif for ESE-2 consists of a GGA core and AT-rich flanks. The expression profiles of these factors are altered in epithelial cancers. Members of this subfamily are potential targets for cancer therapy. Pssm-ID: 188881 Cd Length: 84 Bit Score: 50.40 E-value: 3.37e-08
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SAM_PNT-ETS-1 | cd08542 | Sterile alpha motif (SAM)/Pointed domain of ETS-1; SAM Pointed domain of ETS-1 subfamily of ... |
87-151 | 5.94e-05 | |||
Sterile alpha motif (SAM)/Pointed domain of ETS-1; SAM Pointed domain of ETS-1 subfamily of ETS transcriptional activators is a protein-protein interaction domain. The ETS-1 activator is regulated by phosphorylation. It contains a docking site for the ERK2 MAP (Mitogen Activated Protein) kinase, while the ERK2 phosphorylation site is located in the N-terminal disordered region upstream of the SAM Pointed domain. Mutations of the kinase docking site residues inhibit phosphorylation. ETS-1 activators play a role in a number of different physiological processes, and they are expressed during embryonic development, including blood vessel formation, hematopoietic, lymphoid, neuronal and osteogenic differentiation. The Ets-1 gene is a proto-oncogene involved in progression of different tumors (including breast cancer, meningioma, and prostate cancer). Members of this subfamily are potential molecular targets for selective cancer therapy. Pssm-ID: 176092 Cd Length: 88 Bit Score: 41.50 E-value: 5.94e-05
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SAM_PNT-PDEF-like | cd08532 | Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of ... |
87-148 | 8.00e-05 | |||
Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of PDEF-like (Prostate-Derived ETS Factor) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. In human males this activator is highly expressed in the prostate gland and enhances androgen-mediated activation of the PSA promoter though interaction with the DNA binding domain of androgen receptor. PDEF may play a role in prostate cancer development as well as in goblet cell formation and mucus production in the epithelial lining of respiratory and intestinal tracts. Pssm-ID: 188878 Cd Length: 81 Bit Score: 40.81 E-value: 8.00e-05
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Blast search parameters | ||||
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