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    Tnk2 tyrosine kinase, non-receptor, 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303882, updated on 2-Nov-2024

    Summary

    Official Symbol
    Tnk2provided by RGD
    Official Full Name
    tyrosine kinase, non-receptor, 2provided by RGD
    Primary source
    RGD:1305957
    See related
    EnsemblRapid:ENSRNOG00000001769 AllianceGenome:RGD:1305957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein tyrosine kinase activity. Predicted to be involved in several processes, including positive regulation of peptidyl-tyrosine phosphorylation; regulation of clathrin-dependent endocytosis; and spermatid development. Predicted to be located in several cellular components, including clathrin-coated pit; cytoophidium; and cytoplasmic vesicle. Predicted to be part of Grb2-EGFR complex. Predicted to be active in plasma membrane; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 96.5), Thymus (RPKM 75.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tnk2 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81619795..81659074, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68114725..68154254, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71348726..71388520, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene mucin 4, cell surface associated Neighboring gene uncharacterized LOC134481086 Neighboring gene uncharacterized LOC120095667 Neighboring gene U2 spliceosomal RNA Neighboring gene transferrin receptor Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC94214

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Grb2-EGFR complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoophidium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    activated CDC42 kinase 1
    Names
    ACK-1
    activated p21cdc42Hs kinase
    tyrosine kinase non-receptor protein 2
    NP_001008337.1
    XP_017453469.1
    XP_017453470.1
    XP_017453472.2
    XP_017453473.1
    XP_017453474.1
    XP_017453476.1
    XP_017453479.1
    XP_038944232.1
    XP_038944233.1
    XP_038944234.1
    XP_038944235.1
    XP_038944237.1
    XP_038944239.1
    XP_038944240.1
    XP_038944242.1
    XP_038944243.1
    XP_038944244.1
    XP_038944245.1
    XP_038944249.1
    XP_038944250.1
    XP_063126569.1
    XP_063126571.1
    XP_063126572.1
    XP_063126573.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008336.1NP_001008337.1  activated CDC42 kinase 1

      See identical proteins and their annotated locations for NP_001008337.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085825
      UniProtKB/Swiss-Prot
      Q5U2X5
      UniProtKB/TrEMBL
      F1M7W9
      Related
      ENSRNOP00000002411.4, ENSRNOT00000002411.9
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:126385
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:447514
      GTPase_binding; GTPase binding
      pfam11555
      Location:782838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      81619795..81659074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088306.2XP_038944234.1  activated CDC42 kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A1S7
      Related
      ENSRNOP00000070836.3, ENSRNOT00000084768.3
      Conserved Domains (8) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:6411007
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10221065
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10521091
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:843899
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    2. XM_039088307.1XP_038944235.1  activated CDC42 kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A1S7
      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:632998
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10131056
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10431082
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:145402
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:464529
      GTPase_binding; GTPase binding
      pfam11555
      Location:834890
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:410459
      SH3_9; Variant SH3 domain
    3. XM_039088309.1XP_038944237.1  activated CDC42 kinase 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A1S7
      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:568985
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10001043
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10301069
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    4. XM_039088315.1XP_038944243.1  activated CDC42 kinase 1 isoform X19

      UniProtKB/TrEMBL
      A0A8I6A0G1
      Related
      ENSRNOP00000107502.1, ENSRNOT00000162050.1
      Conserved Domains (6) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:6491027
      PHA03247; large tegument protein UL36; Provisional
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:851907
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    5. XM_039088311.1XP_038944239.1  activated CDC42 kinase 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6A0G1
      Conserved Domains (7) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:6491027
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:10281067
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:851907
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    6. XM_039088305.1XP_038944233.1  activated CDC42 kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A1S7
      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:6491038
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10271071
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10581097
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:851907
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    7. XM_063270503.1XP_063126573.1  activated CDC42 kinase 1 isoform X17

    8. XM_063270501.1XP_063126571.1  activated CDC42 kinase 1 isoform X13

    9. XM_017597984.2XP_017453473.1  activated CDC42 kinase 1 isoform X11

      UniProtKB/TrEMBL
      A0A0G2K2Q7, F1M7W9
    10. XM_063270502.1XP_063126572.1  activated CDC42 kinase 1 isoform X16

      Related
      ENSRNOP00000101899.1, ENSRNOT00000124433.1
    11. XM_063270499.1XP_063126569.1  activated CDC42 kinase 1 isoform X7

    12. XM_017597980.2XP_017453469.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A1S7
      Related
      ENSRNOP00000072336.3, ENSRNOT00000085568.3
    13. XM_039088304.2XP_038944232.1  activated CDC42 kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1S7
      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:6491015
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10301073
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10601099
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:851907
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    14. XM_039088321.2XP_038944249.1  activated CDC42 kinase 1 isoform X23

      UniProtKB/TrEMBL
      A6IRQ0
      Conserved Domains (4) summary
      PHA03247
      Location:127493
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:508551
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:538577
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam11555
      Location:329385
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    15. XM_039088316.2XP_038944244.1  activated CDC42 kinase 1 isoform X20

      UniProtKB/TrEMBL
      A0A0G2JYY3
      Conserved Domains (7) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:619997
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9981037
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:821877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    16. XM_039088317.2XP_038944245.1  activated CDC42 kinase 1 isoform X22

      UniProtKB/TrEMBL
      A0A0G2JYY3
      Conserved Domains (7) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:604982
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9831022
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:806862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    17. XM_017597983.3XP_017453472.2  activated CDC42 kinase 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A1S7
      Conserved Domains (8) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:619995
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10001043
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10301069
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:821877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    18. XM_039088312.2XP_038944240.1  activated CDC42 kinase 1 isoform X15

      UniProtKB/TrEMBL
      F1M7W9
      Conserved Domains (8) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:604970
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9851028
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10151054
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:806862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    19. XM_017597990.2XP_017453479.1  activated CDC42 kinase 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I6A0G1
    20. XM_017597987.2XP_017453476.1  activated CDC42 kinase 1 isoform X14

      UniProtKB/TrEMBL
      F1M7W9
    21. XM_039088314.1XP_038944242.1  activated CDC42 kinase 1 isoform X18

      UniProtKB/TrEMBL
      A0A8I6A0G1
      Conserved Domains (7) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:6271005
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:829885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    22. XM_017597985.3XP_017453474.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      F1M7W9
    23. XM_017597981.3XP_017453470.1  activated CDC42 kinase 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A1S7
    24. XM_039088322.2XP_038944250.1  activated CDC42 kinase 1 isoform X24

      Conserved Domains (4) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain