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    Mapkap1 MAPK associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296648, updated on 3-Apr-2024

    Summary

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    Symbol
    Mapkap1provided by RGD
    Full Name
    MAPK associated protein 1provided by RGD
    Primary source
    RGD:1305363
    See related
    Ensembl:ENSRNOG00000017583 AllianceGenome:RGD:1305363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including TORC2 signaling; positive regulation of peptidyl-serine phosphorylation; and substantia nigra development. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of TORC2 complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human MAPKAP1 (MAPK associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 156.7), Thymus (RPKM 153.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mapkap1 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (38113268..38315913)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (17715813..17918387)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (13484952..13701772)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350352 Neighboring gene PBX homeobox 3 Neighboring gene uncharacterized LOC103691768 Neighboring gene uncharacterized LOC108350353 Neighboring gene ribosomal protein S7, pseudogene 1 Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene heat shock protein family A (Hsp70) member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. Schroder WA, et al. Cell Signal, 2007 Jun. PMID 17303383
    2. A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2. Murata H, et al. J Biol Chem, 2011 Mar 4. PMID 21177249, Free PMC Article
    3. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Jacinto E, et al. Cell, 2006 Oct 6. PMID 16962653
    4. Molecular mechanisms of mTOR-mediated translational control. Ma XM, et al. Nat Rev Mol Cell Biol, 2009 May. PMID 19339977
    5. mTOR signaling in growth control and disease. Laplante M, et al. Cell, 2012 Apr 13. PMID 22500797, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    target of rapamycin complex 2 subunit MAPKAP1
    Names
    SAPK-interacting protein 1
    TORC2 subunit MAPKAP1
    mitogen-activated protein kinase 2-associated protein 1
    mitogen-activated protein kinase associated protein 1
    stress-activated map kinase-interacting protein 1
    target of rapamycin complex 2 subunit MAPKAP1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011964.1 → NP_001011964.1  target of rapamycin complex 2 subunit MAPKAP1

      See identical proteins and their annotated locations for NP_001011964.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079073
      UniProtKB/Swiss-Prot
      Q6AYF1
      Related
      ENSRNOP00000078499.1, ENSRNOT00000119554.1
      Conserved Domains (3) summary
      cd13331
      Location:383 → 490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18 → 129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140 → 266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      38113268..38315913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104765.2 → XP_038960693.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYF1
      Conserved Domains (3) summary
      cd13331
      Location:383 → 490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18 → 129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140 → 266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    2. XM_063283509.1 → XP_063139579.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEY0

    3. XM_063283505.1 → XP_063139575.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYF1

    4. XM_063283510.1 → XP_063139580.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEY0

    5. XM_006233950.4 → XP_006234012.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      See identical proteins and their annotated locations for XP_006234012.1

      UniProtKB/Swiss-Prot
      Q6AYF1
      Conserved Domains (3) summary
      cd13331
      Location:383 → 490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18 → 129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140 → 266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    6. XM_063283506.1 → XP_063139576.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYF1

    7. XM_006233949.4 → XP_006234011.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      See identical proteins and their annotated locations for XP_006234011.1

      UniProtKB/Swiss-Prot
      Q6AYF1
      Conserved Domains (3) summary
      cd13331
      Location:383 → 490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18 → 129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140 → 266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    8. XM_063283508.1 → XP_063139578.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEY0

    9. XM_063283511.1 → XP_063139581.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QCJ2

    10. XM_039104766.2 → XP_038960694.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEY0
      Related
      ENSRNOP00000091071.1
      Conserved Domains (3) summary
      cd13331
      Location:347 → 454
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18 → 129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140 → 266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    11. XM_039104768.2 → XP_038960696.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

      Conserved Domains (2) summary
      cd13331
      Location:191 → 298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:1 → 74
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    12. XM_008761721.3 → XP_008759943.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

      See identical proteins and their annotated locations for XP_008759943.1

      Conserved Domains (2) summary
      cd13331
      Location:191 → 298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:1 → 74
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    13. XM_008761722.3 → XP_008759944.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

      See identical proteins and their annotated locations for XP_008759944.1

      Conserved Domains (2) summary
      cd13331
      Location:191 → 298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:1 → 74
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    14. XM_017591656.3 → XP_017447145.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

      Conserved Domains (2) summary
      cd13331
      Location:191 → 298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:1 → 74
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    15. XM_017591654.3 → XP_017447143.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

      Conserved Domains (2) summary
      cd13331
      Location:191 → 298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:1 → 74
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYF1.1 GenPept UniProtKB/Swiss-Prot:Q6AYF1

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