U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Pdia2 protein disulfide isomerase family A, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287164, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pdia2provided by RGD
    Official Full Name
    protein disulfide isomerase family A, member 2provided by RGD
    Primary source
    RGD:1305164
    See related
    EnsemblRapid:ENSRNOG00000063310 AllianceGenome:RGD:1305164
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pdip
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to act upstream of or within platelet aggregation. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human PDIA2 (protein disulfide isomerase family A member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pdia2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15720301..15723386, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15215824..15218937, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene axin 1 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene regulator of G-protein signaling 11

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A. Okumura M, et al. J Biol Chem, 2014 Sep 26. PMID 25122773, Free PMC Article
    2. GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells. Zhang L, et al. J Biol Chem, 2009 Feb 20. PMID 19103594
    3. Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells. Fu XM, et al. J Steroid Biochem Mol Biol, 2009 May. PMID 19429457, Free PMC Article
    4. pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family. Alanen HI, et al. Antioxid Redox Signal, 2006 Mar-Apr. PMID 16677074

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that BPA, a widely distributed and potentially harmful chemical, inhibits Ero1-PDI-mediated disulfide bond formation.
      Title: Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A.
    2. PDIp can also serve as an effective modulator of the cellular levels and biological actions of endogenous estrogens in the pancreas where estrogen receptors alpha and beta and PDIp are co-present.
      Title: Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells.
    3. a role for both GRP78 and PDI in insulin biosynthesis, although an excess of PDI disrupts normal proinsulin processing.
      Title: GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein disulfide-isomerase A2
    Names
    protein disulfide isomerase associated 2
    protein disulfide isomerase, pancreatic
    NP_001099245.2
    XP_038941296.1
    XP_038941297.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105775.2 → NP_001099245.2  protein disulfide-isomerase A2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A0T0
      Related
      ENSRNOP00000085020.1, ENSRNOT00000099303.2
      Conserved Domains (1) summary
      TIGR01130
      Location:45 → 506
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15720301..15723386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085368.2 → XP_038941296.1  protein disulfide-isomerase A2 isoform X1

      Conserved Domains (1) summary
      TIGR01130
      Location:45 → 440
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    2. XM_039085369.2 → XP_038941297.1  protein disulfide-isomerase A2 isoform X2

      Conserved Domains (1) summary
      TIGR01130
      Location:1 → 336
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RNA

    1. XR_005489718.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools