Sigmar1 sigma non-opioid intracellular receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sigmar1provided by MGI
Official Full Name: sigma non-opioid intracellular receptor 1provided by MGI
Primary source: MGI:MGI:1195268
See related: Ensembl:ENSMUSG00000036078 AllianceGenome:MGI:1195268
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oprs1; Sig1R; sigma1R
Summary: This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]
Expression: Ubiquitous expression in liver adult (RPKM 37.0), subcutaneous fat pad adult (RPKM 22.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 22.05 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41738493..41741359, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41738493..41741359, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study.
Title: Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study.
Activation of the sigma-1 receptor ameliorates neuronal ferroptosis via IRE1alpha after spinal cord injury.
Title: Activation of the sigma-1 receptor ameliorates neuronal ferroptosis via IRE1α after spinal cord injury.
Genetic and Neuroimaging Analysis of SIGMAR1 for Frontotemporal Dementia.
Title: Genetic and Neuroimaging Analysis of SIGMAR1 for Frontotemporal Dementia.
Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury.
Title: Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury.
The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants.
Title: The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants.
Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.
Title: Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.
Pharmacological Analysis of GABAA Receptor and Sigma1R Chaperone Interaction: Research Report I-Investigation of the Anxiolytic, Anticonvulsant and Hypnotic Effects of Allosteric GABAA Receptors' Ligands.
Title: Pharmacological Analysis of GABA(A) Receptor and Sigma1R Chaperone Interaction: Research Report I-Investigation of the Anxiolytic, Anticonvulsant and Hypnotic Effects of Allosteric GABA(A) Receptors' Ligands.
Sigma 1 receptor activation improves retinal structure and function in the Rho[P23H/+] mouse model of autosomal dominant retinitis pigmentosa.
Title: Sigma 1 receptor activation improves retinal structure and function in the Rho(P23H/+) mouse model of autosomal dominant retinitis pigmentosa.
Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo.
Title: Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo.
Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.
Title: Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (112)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled opioid receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sigma non-opioid intracellular receptor 1

Names: opioid receptor, sigma 1; sigma 1 receptor variant SR-1D; sigma 1-type opioid receptor; sigma1-receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286538.1 → NP_001273467.1 sigma non-opioid intracellular receptor 1 isoform 2

See identical proteins and their annotated locations for NP_001273467.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' terminal exon which results in a frameshift compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AF030198, AY390765, BB741155, BB851853

UniProtKB/TrEMBL

B7ZJH6

Conserved Domains (1) summary

pfam04622
Location:13 → 148

ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
NM_001286539.1 → NP_001273468.1 sigma non-opioid intracellular receptor 1 isoform 3

See identical proteins and their annotated locations for NP_001273468.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.

Source sequence(s)

AF030198, AY390764, BB741155, BB851853

Consensus CDS

CCDS71362.1

UniProtKB/TrEMBL

A2AMS0

Related

ENSMUSP00000071492.7, ENSMUST00000071561.7

Conserved Domains (1) summary

pfam04622
Location:13 → 183

ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
NM_001286540.1 → NP_001273469.1 sigma non-opioid intracellular receptor 1 isoform 4

See identical proteins and their annotated locations for NP_001273469.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.

Source sequence(s)

AF030198, AY390766, BB741155, BB851853

UniProtKB/TrEMBL

B7ZJH7

Conserved Domains (1) summary

pfam04622
Location:13 → 176

ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
NM_001286541.1 → NP_001273470.1 sigma non-opioid intracellular receptor 1 isoform 5

See identical proteins and their annotated locations for NP_001273470.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 5) is shorter than isoform 1.

Source sequence(s)

AF030198, AY390768, BB741155, BB851853

UniProtKB/TrEMBL

B7ZJH9

Conserved Domains (1) summary

pfam04622
Location:51 → 147

ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
NM_001286542.1 → NP_001273471.1 sigma non-opioid intracellular receptor 1 isoform 6

See identical proteins and their annotated locations for NP_001273471.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The encoded protein (isoform 6) is shorter than isoform 1.

Source sequence(s)

AL807796

UniProtKB/TrEMBL

B7ZJH8

Conserved Domains (1) summary

pfam04622
Location:36 → 105

ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
NM_001286551.1 → NP_001273480.1 sigma non-opioid intracellular receptor 1 isoform 7

See identical proteins and their annotated locations for NP_001273480.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. This isoform negatively regulates the function of the longest isoform (1) by forming a complex with the latter (PMID 22619170). Variants 7 and 8 encode the same protein.

Source sequence(s)

AF030198, BB741155, BB851853, BM507398

UniProtKB/TrEMBL

I4DCY6

Conserved Domains (1) summary

pfam04622
Location:13 → 102

ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
NM_001286605.1 → NP_001273534.1 sigma non-opioid intracellular receptor 1 isoform 7

See identical proteins and their annotated locations for NP_001273534.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. Variants 7 and 8 encode the same protein.

Source sequence(s)

AL807796

UniProtKB/TrEMBL

I4DCY6

Conserved Domains (1) summary

pfam04622
Location:13 → 102

ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
NM_011014.3 → NP_035144.1 sigma non-opioid intracellular receptor 1 isoform 1

See identical proteins and their annotated locations for NP_035144.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AF030198, BB741155, BB851853

Consensus CDS

CCDS18070.1

UniProtKB/Swiss-Prot

O55242, Q9JKU9

Related

ENSMUSP00000056027.8, ENSMUST00000059354.15

Conserved Domains (1) summary

pfam04622
Location:13 → 214

ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein