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sigma non-opioid intracellular receptor 1 isoform 7 [Mus musculus]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
ERG2_Sigma1R super family | cl18445 | ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase ... |
27-102 | 3.32e-25 | ||
ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyzes a reaction in ergosterol biosynthesis, which results in unsaturation at C-7 in the B ring of sterols. Sigma 1 receptor is a low molecular mass mammalian protein located in the endoplasmic reticulum, which interacts with endogenous steroid hormones, such as progesterone and testosterone. It also binds the sigma ligands, which are are a set of chemically unrelated drugs including haloperidol, pentazocine, and ditolylguanidine. Sigma1 effectors are not well understood, but sigma1 agonists have been observed to affect NMDA receptor function, the alpha-adrenergic system and opioid analgesia. The actual alignment was detected with superfamily member pfam04622: Pssm-ID: 461372 Cd Length: 192 Bit Score: 93.34 E-value: 3.32e-25
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Name | Accession | Description | Interval | E-value | ||
ERG2_Sigma1R | pfam04622 | ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase ... |
27-102 | 3.32e-25 | ||
ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyzes a reaction in ergosterol biosynthesis, which results in unsaturation at C-7 in the B ring of sterols. Sigma 1 receptor is a low molecular mass mammalian protein located in the endoplasmic reticulum, which interacts with endogenous steroid hormones, such as progesterone and testosterone. It also binds the sigma ligands, which are are a set of chemically unrelated drugs including haloperidol, pentazocine, and ditolylguanidine. Sigma1 effectors are not well understood, but sigma1 agonists have been observed to affect NMDA receptor function, the alpha-adrenergic system and opioid analgesia. Pssm-ID: 461372 Cd Length: 192 Bit Score: 93.34 E-value: 3.32e-25
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Name | Accession | Description | Interval | E-value | ||
ERG2_Sigma1R | pfam04622 | ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase ... |
27-102 | 3.32e-25 | ||
ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyzes a reaction in ergosterol biosynthesis, which results in unsaturation at C-7 in the B ring of sterols. Sigma 1 receptor is a low molecular mass mammalian protein located in the endoplasmic reticulum, which interacts with endogenous steroid hormones, such as progesterone and testosterone. It also binds the sigma ligands, which are are a set of chemically unrelated drugs including haloperidol, pentazocine, and ditolylguanidine. Sigma1 effectors are not well understood, but sigma1 agonists have been observed to affect NMDA receptor function, the alpha-adrenergic system and opioid analgesia. Pssm-ID: 461372 Cd Length: 192 Bit Score: 93.34 E-value: 3.32e-25
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