U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Lama5 laminin, alpha 5 [ Mus musculus (house mouse) ]

    Gene ID: 16776, updated on 2-Nov-2024

    Summary

    Official Symbol
    Lama5provided by MGI
    Official Full Name
    laminin, alpha 5provided by MGI
    Primary source
    MGI:MGI:105382
    See related
    Ensembl:ENSMUSG00000015647 AllianceGenome:MGI:105382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    [a]5; mKIAA0533; laminin-511
    Summary
    Enables integrin binding activity. Involved in postsynapse organization. Acts upstream of or within several processes, including hair follicle development; morphogenesis of an epithelium; and trunk neural crest cell migration. Located in extracellular matrix. Part of laminin-10 complex. Is active in several cellular components, including collagen-containing extracellular matrix; glutamatergic synapse; and synaptic cleft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; salivary gland primordium; and sensory organ. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human LAMA5 (laminin subunit alpha 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 40.7), mammary gland adult (RPKM 30.3) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lama5 in Genome Data Viewer
    Location:
    2 H4; 2 102.7 cM
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179818166..179867652, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180176373..180225904, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 2 Neighboring gene predicted gene, 29886 Neighboring gene STARR-positive B cell enhancer mm9_chr2:179905789-179906089 Neighboring gene adhesion regulating molecule 1 26S proteasome ubiquitin receptor Neighboring gene microRNA 7005 Neighboring gene STARR-seq mESC enhancer starr_06728 Neighboring gene STARR-seq mESC enhancer starr_06729 Neighboring gene STARR-positive B cell enhancer ABC_E6036 Neighboring gene microRNA 3091 Neighboring gene CDK5 and Abl enzyme substrate 2 Neighboring gene STARR-positive B cell enhancer ABC_E333 Neighboring gene ribosomal protein S21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of a polarized epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within trunk neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular matrix of synaptic cleft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular matrix of synaptic cleft IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in extracellular matrix of synaptic cleft IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of laminin-10 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of laminin-10 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of laminin-5 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of laminin-5 complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    laminin subunit alpha-5
    Names
    laminin-10 subunit alpha
    laminin-11 subunit alpha
    laminin-15 subunit alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081171.2NP_001074640.1  laminin subunit alpha-5 precursor

      See identical proteins and their annotated locations for NP_001074640.1

      Status: VALIDATED

      Source sequence(s)
      AI853660, AJ293593, AK158204, AL663027, CJ124774, CK021961, CN702366, DV646114
      Consensus CDS
      CCDS38375.1
      UniProtKB/Swiss-Prot
      A2ABW7, Q61001, Q9JHQ6
      Related
      ENSMUSP00000015791.6, ENSMUST00000015791.6
      Conserved Domains (10) summary
      smart00180
      Location:20252069
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:16901819
      LamB; Laminin B domain
      smart00282
      Location:35423669
      LamG; Laminin G domain
      cd00055
      Location:682724
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:33373495
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:14431491
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:59303
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam06008
      Location:21902452
      Laminin_I; Laminin Domain I
      pfam06009
      Location:26422764
      Laminin_II; Laminin Domain II
      cl02193
      Location:22302316
      VirB5_like; VirB5 protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179818166..179867652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)