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    Mtif2 mitochondrial translational initiation factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 76784, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Mtif2provided by MGI
    Official Full Name
    mitochondrial translational initiation factor 2provided by MGI
    Primary source
    MGI:MGI:1924034
    See related
    Ensembl:ENSMUSG00000020459 AllianceGenome:MGI:1924034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IF-2mt; IF2(mt); IF-2(Mt); 2310038D14Rik; 2410112O06Rik
    Summary
    Predicted to enable ribosomal small subunit binding activity and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation and ribosome disassembly. Located in mitochondrion. Is expressed in liver lobe; testis; and vibrissa. Orthologous to human MTIF2 (mitochondrial translational initiation factor 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.0), CNS E14 (RPKM 7.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtif2 in Genome Data Viewer
    Location:
    11 A3.3; 11 16.77 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29475352..29495452)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29525352..29545452)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled coil domain containing 88A Neighboring gene predicted gene, 51886 Neighboring gene STARR-seq mESC enhancer starr_29023 Neighboring gene STARR-positive B cell enhancer ABC_E3936 Neighboring gene prolyl-tRNA synthetase domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:29426294-29426403 Neighboring gene STARR-seq mESC enhancer starr_29024 Neighboring gene ribosomal protein S27A Neighboring gene 60S ribosomal protein L7-like Neighboring gene clathrin heavy chain linker domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. Koc EC, et al. J Biol Chem, 2002 Sep 20. PMID 12095986
    2. Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry. Jin WH, et al. Rapid Commun Mass Spectrom, 2004. PMID 15378723
    3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    4. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 2310038D14Rik, 2410112O06Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation factor activity, RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    translation initiation factor IF-2, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282118.1 → NP_001269047.1  translation initiation factor IF-2, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001269047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK136344, BX284634, CF737093
      Consensus CDS
      CCDS24496.1
      UniProtKB/Swiss-Prot
      Q5M6W6, Q91YJ5
      Related
      ENSMUSP00000020749.7, ENSMUST00000020749.13
      Conserved Domains (1) summary
      cl30717
      Location:72 → 720
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    2. NM_001282119.1 → NP_001269048.1  translation initiation factor IF-2, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK136344, BX284634, CF737093, CK620846
      UniProtKB/Swiss-Prot
      Q91YJ5
      Conserved Domains (5) summary
      cd01887
      Location:200 → 364
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      COG0532
      Location:195 → 737
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam11987
      Location:534 → 625
      IF-2; Translation-initiation factor 2
      cd03692
      Location:643 → 730
      mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
      cd03702
      Location:373 → 467
      IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2

    3. NM_001282120.1 → NP_001269049.1  translation initiation factor IF-2, mitochondrial isoform 3

      See identical proteins and their annotated locations for NP_001269049.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK146961, BX284634, CF737093, CK620846
      UniProtKB/Swiss-Prot
      Q91YJ5
      Conserved Domains (1) summary
      cl30717
      Location:25 → 574
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    4. NM_133767.3 → NP_598528.2  translation initiation factor IF-2, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_598528.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK146961, BX284634, CF737093, CK620846
      Consensus CDS
      CCDS24496.1
      UniProtKB/Swiss-Prot
      Q5M6W6, Q91YJ5
      Related
      ENSMUSP00000090926.5, ENSMUST00000093239.11
      Conserved Domains (1) summary
      cl30717
      Location:72 → 720
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      29475352..29495452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514892.4 → XP_006514955.1  translation initiation factor IF-2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006514955.1

      UniProtKB/Swiss-Prot
      Q5M6W6, Q91YJ5
      Conserved Domains (1) summary
      cl30717
      Location:72 → 720
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    2. XM_036157080.1 → XP_036012973.1  translation initiation factor IF-2, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl30717
      Location:25 → 574
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    3. XM_030246423.1 → XP_030102283.1  translation initiation factor IF-2, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl30717
      Location:1 → 624
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    4. XM_030246424.1 → XP_030102284.1  translation initiation factor IF-2, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl30717
      Location:25 → 574
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    5. XM_036157081.1 → XP_036012974.1  translation initiation factor IF-2, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl30717
      Location:25 → 574
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    6. XM_006514891.3 → XP_006514954.1  translation initiation factor IF-2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006514954.1

      UniProtKB/Swiss-Prot
      Q5M6W6, Q91YJ5
      Conserved Domains (1) summary
      cl30717
      Location:72 → 720
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_003949529.1 RNA Sequence

    2. XR_380987.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YJ5.2 GenPept UniProtKB/Swiss-Prot:Q91YJ5

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