4KJZ,1G7S


Conserved Protein Domain Family
IF-2
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pfam11987: IF-2 (this model, PSSM-Id:288813 is obsolete and has been replaced by 463421)
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Translation-initiation factor 2
IF-2 is a translation initiator in each of the three main phylogenetic domains (Eukaryotes, Bacteria and Archaea). IF2 interacts with formylmethionine-tRNA, GTP, IF1, IF3 and both ribosomal subunits. Through these interactions, IF2 promotes the binding of the initiator tRNA to the A site in the smaller ribosomal subunit and catalyzes the hydrolysis of GTP following initiation-complex formation.
Links
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Statistics
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PSSM-Id: 288813
Aligned: 641 rows
Threshold Bit Score: 35.0857
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4KJZ_D        358 AELLRAMQeEGr--KELNLILRADTQGSLEAIQHILARes----tEDv----kINILLAQVGAPTESDVLLAQTANAAIL 427  Thermus therm...
Q4UA29        409 kNFQNEDSdRY---KYIPTIIRCDVKAIVEPIKMAIEKlr----sTGiskickYKVLDADIDNLTQDDVDLFDKP-GIVV 480  Theileria ann...
Q6CX64        452 deEQAEVEsGP---KDVNFIIKADVSGSVEAIVQSIEHlg----nDEv----kCNIVGSSVGVPAENDLKMAKITGSTIL 520  Kluyveromyces...
P25038        458 TVQEHEQNtGP---KLINYIIKCDVSGSAEAVSESISSlg----nDEv----rCNVISSSVGIPTESDLKMAQITESTIL 526  Saccharomyces...
CCK71948      473 aepEAVTNtTP---KSVNFIIKSDVSGSAEAVRESIENlg----nGEv----qCKVISSSVGIPTESDLKMAQITNSIIV 541  Kazachstania ...
XP_003980260  468 ndeENIVEkGP---KQINFIVKSDVSGSAEAIQESIASlg----nDEv----kCTVISSTVGLPTEGDYKMAQITNSQIF 536  Naumovozyma d...
XP_002556444  454 etgANAKDeGP---KKVNFIVKGDVSGSVEAIVESIASlg----nEEv----rCNIVTASVGIPNENDMKMARITGSKLL 522  Lachancea the...
XP_004179487  372 dsdSEIVKpKT---KKINFIIKADTQGSLEAVIDSIRNfg----nDEv----rTCIVAYSVGQPTINDKKLAEITNSTIL 440  Tetrapisispor...
WP_013315273  288 kknksSKNyEG---KKLNLILKSYNYGNQKSILNILTKfy----nKYg----kIKIINYSIGDININDIILCKNTNSIII 356  Candidatus Zi...
XP_002259650 1157 EREIKNFQeKDlrtVYVSYFIKCDKQGTIDVLKNCLQKlqvndtlHRv----rNKIVYSSIGDITASDITYAQSFDAIII 1232 Plasmodium kn...

4KJZ_D        428 AFGV-NPPGSVKKKAE------EK---GVLLKTFRIIYDLVDEV 461  Thermus thermophilus HB8
Q4UA29        481 AYNS-TISSTMQNKLK------KQ---EIKLISGEKIEDIVKta 514  Theileria annulata
Q6CX64        521 CFNLdNVPNDIINNKD-----------KIPVKQFNVIYKLIEDV 553  Kluyveromyces lactis
P25038        527 CFNLgNLPSEVINNRA-----------GIKIKQYNVIYKLIEDV 559  Saccharomyces cerevisiae S288c
CCK71948      542 CFNLaSLPNDIINNKQ-----------HVEIRRYDVIYKLIEDV 574  Kazachstania naganishii CBS 8797
XP_003980260  537 CFNLgNLPNDIINNKY-----------HIPIKQFNVIYKLIEEV 569  Naumovozyma dairenensis CBS 421
XP_002556444  523 CFNLgSLPHDIINNKD-----------DIEVAQFNVIYKLIEDV 555  Lachancea thermotolerans CBS 6340
XP_004179487  441 CFNL-DNSNSIKPDSK------PNeneKIKIKYYNVIYKLIDDV 477  Tetrapisispora blattae CBS 6284
WP_013315273  357 AFNL-YENKELLNFKK------KY---NIKIYYFYIIYDILKKL 390  Candidatus Zinderia insecticola
XP_002259650 1233 GFNV-KLSKSFPKNGKnitsggKS---NSRIIYVNVLYDLIEEV 1272 Plasmodium knowlesi strain H
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