Nes nestin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nesprovided by MGI
Official Full Name: nestinprovided by MGI
Primary source: MGI:MGI:101784
See related: Ensembl:ENSMUSG00000004891 AllianceGenome:MGI:101784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RC2; Marc2; ESTM46; Ifaprc2
Summary: Predicted to enable CCR5 chemokine receptor binding activity and intermediate filament binding activity. Acts upstream of or within cell projection morphogenesis; negative regulation of neuron apoptotic process; and nervous system development. Located in cytoplasm and intermediate filament. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; foregut-midgut junction; and metanephros. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 68.0), CNS E14 (RPKM 14.9) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.78 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87878400..87887758)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (87971093..87980451)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High frequency of germline recombination in Nestin-Cre transgenic mice crossed with Glucagon-like peptide 1 receptor floxed mice.
Title: High frequency of germline recombination in Nestin-Cre transgenic mice crossed with Glucagon-like peptide 1 receptor floxed mice.
Nestin Regulates Muller Glia Proliferation After Retinal Injury.
Title: Nestin Regulates Müller Glia Proliferation After Retinal Injury.
Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial-mesenchymal transition in lung endothelial cells.
Title: Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial-mesenchymal transition in lung endothelial cells.
Nestin is a marker of unipotent embryonic and adult progenitors differentiating into an epithelial cell lineage of the hair follicles.
Title: Nestin is a marker of unipotent embryonic and adult progenitors differentiating into an epithelial cell lineage of the hair follicles.
USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage.
Title: USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage.
Nestin promotes pulmonary fibrosis via facilitating recycling of TGF-beta receptor I.
Title: Nestin promotes pulmonary fibrosis via facilitating recycling of TGF-β receptor I.
Nestin affects fusion pore dynamics in mouse astrocytes.
Title: Nestin affects fusion pore dynamics in mouse astrocytes.
Sox17 Controls Emergence and Remodeling of Nestin-Expressing Coronary Vessels.
Title: Sox17 Controls Emergence and Remodeling of Nestin-Expressing Coronary Vessels.
Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells.
Title: Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells.
Nestin Null Mice Show Improved Reversal Place Learning.
Title: Nestin Null Mice Show Improved Reversal Place Learning.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126381 (e-PCR)
- UniSTS:163089

Nes (e-PCR), detects polymorphism
- UniSTS:480306

Nes (e-PCR), detects polymorphism
- UniSTS:527448

PMC304098P5 (e-PCR)
- UniSTS:272524

UniSTS:497298 (e-PCR)
- UniSTS:497298

Nes (e-PCR), detects polymorphism
- UniSTS:497298

C78523 (e-PCR)
- UniSTS:159131

Nes (e-PCR), detects polymorphism
- UniSTS:275869

AA166324 (e-PCR), detects polymorphism
- UniSTS:143032

Nes (e-PCR), detects polymorphism
- UniSTS:265672

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR5 chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR5 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables intermediate filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intermediate filament depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intermediate filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intermediate filament depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nestin

Names: intermediate filament protein; intermediate filament-associated protein RC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016701.3 → NP_057910.3 nestin

See identical proteins and their annotated locations for NP_057910.3

Status: VALIDATED

Source sequence(s)

BC062893

Consensus CDS

CCDS17461.1

UniProtKB/Swiss-Prot

A1E2I2, Q6P5H2, Q80X00, Q8BPH7, Q9CV43, Q9R0C4

Related

ENSMUSP00000088493.6, ENSMUST00000090973.12

Conserved Domains (1) summary

pfam00038
Location:7 → 313

Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

87878400..87887758

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162920.1 → XP_036018813.1 nestin isoform X1

Conserved Domains (2) summary

PTZ00121
Location:281 → 795

PTZ00121; MAEBL; Provisional

COG5271
Location:606 → 1051

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]