TLR3 toll like receptor 3 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: TLR3provided by VGNC
Official Full Name: toll like receptor 3provided by VGNC
Primary source: VGNC:VGNC:52833
See related: BGD:BT12268; Ensembl:ENSBTAG00000008682
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	27	NC_037354.1 (16176313..16195485)

Chromosome 27 - NC_037354.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves
Title: Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves.
On day 104 of pregnancy, mRNA expression of TLRs 3 and 8, as well as that of TLRs 7 and 9, was high in the spleen of fetuses from Neospora caninum-infected heifers. Gene expression levels of endosomal TLRs were also detectable in the placenta and the maternal caruncle from infected heifers, being TLRs 3, 7 and 8 particularly upregulated, mostly in the caruncle.
Title: Toll-like receptors 3, 7 and 8 are upregulated in the placental caruncle and fetal spleen of Neospora caninum experimentally infected cattle.
The results from this study demonstrate that expression of at least TLR3, TLR7 and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.
Title: Involvement of toll-like receptors 3 and 7/8 in the neuropathogenesis of bovine herpesvirus types 1 and 5.
Comparative sequence analysis revealed a total of 139 polymorphisms, which include single-nucleotide polymorphisms and insertion-deletion polymorphisms.
Title: Detection of polymorphisms in bovine toll-like receptors 3, 7, 8, and 9.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: toll-like receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008664.1 → NP_001008664.1 toll-like receptor 3 precursor

See identical proteins and their annotated locations for NP_001008664.1

Status: PROVISIONAL

Source sequence(s)

AJ812026

UniProtKB/Swiss-Prot

Q5TJ59

UniProtKB/TrEMBL

A0A7D5VUH5

Conserved Domains (6) summary

smart00255
Location:755 → 900

TIR; Toll - interleukin 1 - resistance

cd00116
Location:434 → 648

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:483 → 499

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:34 → 53

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:275 → 332

LRR_8; Leucine rich repeat

cl15307
Location:646 → 698

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

Range

16176313..16195485

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010820242.4 → XP_010818544.2 toll-like receptor 3 isoform X1

UniProtKB/TrEMBL

A0A3S5ZPK8, A5H649, F1MZZ6

Related

ENSBTAP00000011445.6, ENSBTAT00000011445.6

Conserved Domains (4) summary

smart00255
Location:768 → 896

TIR; Toll - interleukin 1 - resistance

sd00033
Location:47 → 66

LRR_RI; leucine-rich repeat [structural motif]

cl15307
Location:659 → 711

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl26793
Location:86 → 659

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional