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Conserved domains on  [gi|56710323|ref|NP_001008664|]
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toll-like receptor 3 precursor [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
755-900 1.00e-21

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 92.00  E-value: 1.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323    755 EYAAYIIHAYKDrdWVWKHSSPM-EDEDHTLRFCLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCkRFKVH 833
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHlLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWC-LDELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56710323    834 HAVQQAIEQNLDSIILIFLEEIPDYKLNHALCLRRGMFKShcILNWPVQKERvnAFHHKLKVALGSR 900
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWPEDEKE--QFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-416 4.67e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 4.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  52 TNITVLNLTHNQlrrlppaNFTRYSQLTTLDGGFNSISKLEPELCQsLPWLEILNLQHNEISQLsDKTFIFCMNLTELHL 131
Cdd:COG4886  96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 132 MSNSIQKIKnDPFKNLKNLIKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPgefDFLGNSSLKRLELSSNQIK 211
Cdd:COG4886 167 SNNQLTDLP-EELGNLTNLKELDLS------------------------NNQITDLPE---PLGNLTNLEELDLSGNQLT 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 212 EFsPGCFHTLGELSGLSLNNAKLS--PSLTeklclelSNTSIENLSLSSNQLDTISHTtfdgLKQTNLTTLDLSRNSLRV 289
Cdd:COG4886 219 DL-PEPLANLTNLETLDLSNNQLTdlPELG-------NLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTD 286

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 290 MGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQSISLTSLPKIDDFSFQWLKCLEYLNMDDNNFP 369
Cdd:COG4886 287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 56710323 370 GIKRNTFTGLVRLKFLSLSNSFSSLRTLTNETFLSLAGCPLLLLDLT 416
Cdd:COG4886 367 LTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-667 4.10e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 303 YLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQSISLTSLPKIDDFSFQWLKCLEYLNMDDNNFPGIKRNTFTGLVRL 382
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 383 KFLSLSNSFSSLRTLTNETFLSLAGCPLLL-------LDLTKNKISKIqSGAFSWLGHLEVLDLGLNEIGQelTGQEWRG 455
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSnltnlesLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPEPLGN 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 456 LDNIVEIYLSYNKYLELTtNSFTSVPSLQRLMLRRVALKNVdcsPSPFRPLPNLVILDLSNNNIANINDELlKGLEKLEI 535
Cdd:COG4886 158 LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLET 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 536 LDLQHNNLARLwkhanpggpvQFLKGLFHLHILNLGSNGFDEIPVEAfkDLRELKSIDLGMNNLNILPQSVFDNQVSLKS 615
Cdd:COG4886 233 LDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 56710323 616 LSLQKNLITSVQKTVFGPAFRNLSYLDMRFNPFDCTCESIAWFVNWINITHT 667
Cdd:COG4886 301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 699-731 6.71e-06

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


:

Pssm-ID: 465595  Cd Length: 33  Bit Score: 43.45  E-value: 6.71e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 56710323   699 DSAPFELLFMININILLIFIFIVLLIHFEGWRI 731
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
646-698 3.17e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 3.17e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56710323    646 NPFDCTCEsIAWFVNWINitHTNISELSNHYLCNTPPQYHGyPV--MLFDVSPCK 698
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQ--ANEHLQDPVDLRCASPSSLRG-PLleLLHSEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
755-900 1.00e-21

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 92.00  E-value: 1.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323    755 EYAAYIIHAYKDrdWVWKHSSPM-EDEDHTLRFCLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCkRFKVH 833
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHlLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWC-LDELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56710323    834 HAVQQAIEQNLDSIILIFLEEIPDYKLNHALCLRRGMFKShcILNWPVQKERvnAFHHKLKVALGSR 900
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWPEDEKE--QFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-416 4.67e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 4.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  52 TNITVLNLTHNQlrrlppaNFTRYSQLTTLDGGFNSISKLEPELCQsLPWLEILNLQHNEISQLsDKTFIFCMNLTELHL 131
Cdd:COG4886  96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 132 MSNSIQKIKnDPFKNLKNLIKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPgefDFLGNSSLKRLELSSNQIK 211
Cdd:COG4886 167 SNNQLTDLP-EELGNLTNLKELDLS------------------------NNQITDLPE---PLGNLTNLEELDLSGNQLT 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 212 EFsPGCFHTLGELSGLSLNNAKLS--PSLTeklclelSNTSIENLSLSSNQLDTISHTtfdgLKQTNLTTLDLSRNSLRV 289
Cdd:COG4886 219 DL-PEPLANLTNLETLDLSNNQLTdlPELG-------NLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTD 286

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 290 MGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQSISLTSLPKIDDFSFQWLKCLEYLNMDDNNFP 369
Cdd:COG4886 287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 56710323 370 GIKRNTFTGLVRLKFLSLSNSFSSLRTLTNETFLSLAGCPLLLLDLT 416
Cdd:COG4886 367 LTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-667 4.10e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 303 YLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQSISLTSLPKIDDFSFQWLKCLEYLNMDDNNFPGIKRNTFTGLVRL 382
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 383 KFLSLSNSFSSLRTLTNETFLSLAGCPLLL-------LDLTKNKISKIqSGAFSWLGHLEVLDLGLNEIGQelTGQEWRG 455
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSnltnlesLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPEPLGN 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 456 LDNIVEIYLSYNKYLELTtNSFTSVPSLQRLMLRRVALKNVdcsPSPFRPLPNLVILDLSNNNIANINDELlKGLEKLEI 535
Cdd:COG4886 158 LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLET 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 536 LDLQHNNLARLwkhanpggpvQFLKGLFHLHILNLGSNGFDEIPVEAfkDLRELKSIDLGMNNLNILPQSVFDNQVSLKS 615
Cdd:COG4886 233 LDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 56710323 616 LSLQKNLITSVQKTVFGPAFRNLSYLDMRFNPFDCTCESIAWFVNWINITHT 667
Cdd:COG4886 301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 73-543 6.92e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.96  E-value: 6.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   73 TRYSQLTTLD-GGFNSISKLEPELCQsLPWLEILNLQHNEIS-QLSDKTFIFCMNLTELHLMSNSIQKikNDPFKNLKNL 150
Cdd:PLN00113  66 NNSSRVVSIDlSGKNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG--SIPRGSIPNL 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  151 IKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPGEFDFLgnSSLKRLELSSNQIKEFSPGCFHTLGELSGLSLn 230
Cdd:PLN00113 143 ETLDLS------------------------NNMLSGEIPNDIGSF--SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTL- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  231 nakLSPSLTEKLCLELSNT-SIENLSLSSNQLDTISHTTFDGLkqTNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYN 309
Cdd:PLN00113 196 ---ASNQLVGQIPRELGQMkSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  310 NIEHLSSRSFYGLSNLRRLDLRRSFTRQSIsltslPKIddfsFQWLKCLEYLNMDDNNFPGIKRNTFTGLVRLKFLSLSN 389
Cdd:PLN00113 271 KLSGPIPPSIFSLQKLISLDLSDNSLSGEI-----PEL----VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWS 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  390 sfsslRTLTNETFLSLAG-CPLLLLDLTKNKIS-KIQSGAFSwLGHLEVLDLGLNEIGQE-------------------- 447
Cdd:PLN00113 342 -----NKFSGEIPKNLGKhNNLTVLDLSTNNLTgEIPEGLCS-SGNLFKLILFSNSLEGEipkslgacrslrrvrlqdns 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  448 LTGQEWRGLDNIVEIYlsynkYLELTTNSFT--------SVPSLQRLMLRRVA-------------LKNVDCS------- 499
Cdd:PLN00113 416 FSGELPSEFTKLPLVY-----FLDISNNNLQgrinsrkwDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsga 490

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 56710323  500 -PSPFRPLPNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNL 543
Cdd:PLN00113 491 vPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR_8 pfam13855
Leucine rich repeat;
275-332 1.65e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.65e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 56710323   275 TNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRR 332
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 413-541 1.37e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 413 LDLTKNKISKIQSgaFSWLGHLEVLDLGLNEIgQELTGQEwrGLDNIVEIYLSYNK-----YLELTTNSFTSV-PSLQRL 486
Cdd:cd21340  51 LYLQNNQIEKIEN--LENLVNLKKLYLGGNRI-SVVEGLE--NLTNLEELHIENQRlppgeKLTFDPRSLAALsNSLRVL 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56710323 487 MLRRvalKNVDcSPSPFRPLPNLVILDLSNNNIANIND--ELLKGLEKLEILDLQHN 541
Cdd:cd21340 126 NISG---NNID-SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
481-543 1.46e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56710323   481 PSLQRLMLRRVALKNVDcsPSPFRPLPNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNL 543
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-208 6.68e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 6.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  38 CSHLKLTQIPD-DLPTNITVLNLTHNQLRRLPpaNFTRYSQLTTLDGGFNSISKLEPElcQSLPWLEILNLQHNEISQLS 116
Cdd:cd21340   9 LNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRISVVE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 117 --DKtfifCMNLTELHLMSNSI---QKIKNDPFKNL---KNLIKLDLSHNGLSStkLGTQLQLENLQELLLSNNKISSLT 188
Cdd:cd21340  85 glEN----LTNLEELHIENQRLppgEKLTFDPRSLAalsNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                       170       180
                ....*....|....*....|
gi 56710323 189 PGEFDFLGNSSLKRLELSSN 208
Cdd:cd21340 159 ELLDLLSSWPSLRELDLTGN 178
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 787-880 2.42e-06

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 48.51  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   787 CLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCkRFKVHHAVQQAIEQNLdSIILIFLEEIPDYKLNHALCL 866
Cdd:pfam01582  32 FIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWC-LDELVKILECALDLGQ-KVIPIFYEVDPSDVRKQTGSF 109

                          90       100
                  ....*....|....*....|.
gi 56710323   867 RRGmFKSHC-------ILNWP 880
Cdd:pfam01582 110 GKA-FKKHKkvlteekVLKWR 129
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 699-731 6.71e-06

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


Pssm-ID: 465595  Cd Length: 33  Bit Score: 43.45  E-value: 6.71e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 56710323   699 DSAPFELLFMININILLIFIFIVLLIHFEGWRI 731
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
468-692 2.49e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 2.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  468 KYLELTTNSFTSVPSLQRLMLRRVALKNVDCSPSPFRpLPN-LVILDLSNNNIANINDELLKGLEKLEILDlqhNNLARL 546
Cdd:PRK15370 223 KTLYANSNQLTSIPATLPDTIQEMELSINRITELPER-LPSaLQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTL 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  547 WKHAnPGGPVQ---------FLKGLF--HLHILNLGSNGFDEIPvEAFKDlrELKSIDLGMNNLNILPQSVfdnQVSLKS 615
Cdd:PRK15370 299 PAHL-PSGITHlnvqsnsltALPETLppGLKTLEAGENALTSLP-ASLPP--ELQVLDVSKNQITVLPETL---PPTITT 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  616 LSLQKNLITSVQKTVfgPAfrNLSYLDMRFNPFDCTCESIAWFVN------WINITHTNISE--LSNHYLCNTPPQYHGy 687
Cdd:PRK15370 372 LDVSRNALTNLPENL--PA--ALQIMQASRNNLVRLPESLPHFRGegpqptRIIVEYNPFSErtIQNMQRLMSSVGYQG- 446


                 ....*
gi 56710323  688 PVMLF 692
Cdd:PRK15370 447 PRVLF 451
LRRCT smart00082
Leucine rich repeat C-terminal domain;
646-698 3.17e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 3.17e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56710323    646 NPFDCTCEsIAWFVNWINitHTNISELSNHYLCNTPPQYHGyPV--MLFDVSPCK 698
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQ--ANEHLQDPVDLRCASPSSLRG-PLleLLHSEFKCP 51
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 618-690 9.98e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.15  E-value: 9.98e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56710323    618 LQKNLITSVQKTVFGPAFrNLSYLDMRFNPFDCTCeSIAWFVNWINITHTNISElSNHYLCNTPPQYHGYPVM 690
Cdd:TIGR00864    2 ISNNKISTIEEGICANLC-NLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVRQ-PEAALCAGPGALAGQPLL 71
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
755-900 1.00e-21

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 92.00  E-value: 1.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323    755 EYAAYIIHAYKDrdWVWKHSSPM-EDEDHTLRFCLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCkRFKVH 833
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHlLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWC-LDELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56710323    834 HAVQQAIEQNLDSIILIFLEEIPDYKLNHALCLRRGMFKShcILNWPVQKERvnAFHHKLKVALGSR 900
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWPEDEKE--QFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-416 4.67e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 4.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  52 TNITVLNLTHNQlrrlppaNFTRYSQLTTLDGGFNSISKLEPELCQsLPWLEILNLQHNEISQLsDKTFIFCMNLTELHL 131
Cdd:COG4886  96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 132 MSNSIQKIKnDPFKNLKNLIKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPgefDFLGNSSLKRLELSSNQIK 211
Cdd:COG4886 167 SNNQLTDLP-EELGNLTNLKELDLS------------------------NNQITDLPE---PLGNLTNLEELDLSGNQLT 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 212 EFsPGCFHTLGELSGLSLNNAKLS--PSLTeklclelSNTSIENLSLSSNQLDTISHTtfdgLKQTNLTTLDLSRNSLRV 289
Cdd:COG4886 219 DL-PEPLANLTNLETLDLSNNQLTdlPELG-------NLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTD 286

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 290 MGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQSISLTSLPKIDDFSFQWLKCLEYLNMDDNNFP 369
Cdd:COG4886 287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 56710323 370 GIKRNTFTGLVRLKFLSLSNSFSSLRTLTNETFLSLAGCPLLLLDLT 416
Cdd:COG4886 367 LTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-287 9.22e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 9.22e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  37 DCSHLKLTQIPDDLP--TNITVLNLTHNQLRRLPPAnFTRYSQLTTLDGGFNSISKLEPELCQsLPWLEILNLQHNEISQ 114
Cdd:COG4886 142 DLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTD 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 115 LSDkTFIFCMNLTELHLMSNSIQKIKNdpFKNLKNLIKLDLSHNGLSStkLGTQLQLENLQELLLSNNKISSLTPGEFDF 194
Cdd:COG4886 220 LPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 195 LGNSSLKRLELSSNQIKEFSPGcFHTLGELSGLSLNNAKLSPSLTEKLCLELSNTSIENLSLSSNQLDTISHTTFDGLKQ 274
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLIL-LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                       250
                ....*....|...
gi 56710323 275 TNLTTLDLSRNSL 287
Cdd:COG4886 374 LLEATLLTLALLL 386
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-479 1.44e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 1.44e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  78 LTTLDGGFNSISKLEPELCQSLPWLEILNLQHNEISQLSDKTFIFCMNLTELHLMSNSIQKIKNDPFKNLKNLIKLDLSH 157
Cdd:COG4886  26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 158 NGLSStklgtqlQLENLQELLLSNNKISSLtPGEFDFLGNssLKRLELSSNQIKEFSPGCFHtLGELSGLSLNNAKLSps 237
Cdd:COG4886 106 NEELS-------NLTNLESLDLSGNQLTDL-PEELANLTN--LKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLT-- 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 238 lteKLCLELSN-TSIENLSLSSNQLDTISHtTFDGLkqTNLTTLDLSRNSLRVMGnDSFAWLPHLEYLSLEYNNIEHLSs 316
Cdd:COG4886 173 ---DLPEELGNlTNLKELDLSNNQITDLPE-PLGNL--TNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP- 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 317 rSFYGLSNLRRLDLRRSftrqsiSLTSLPKIDDfsfqwLKCLEYLNMDDNNFPGIKRNTFTGLVRLKFLSLSNSFSSLRt 396
Cdd:COG4886 245 -ELGNLTNLEELDLSNN------QLTDLPPLAN-----LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL- 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 397 LTNETFLSLAGCPLLLLDLTKNKISKIQSGAFSWLGHLEVLDLGLNEIGQELTGQEWRGLDNIVEIYLSYNKYLELTTNS 476
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391


                ...
gi 56710323 477 FTS 479
Cdd:COG4886 392 LLL 394
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-667 4.10e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 303 YLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQSISLTSLPKIDDFSFQWLKCLEYLNMDDNNFPGIKRNTFTGLVRL 382
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 383 KFLSLSNSFSSLRTLTNETFLSLAGCPLLL-------LDLTKNKISKIqSGAFSWLGHLEVLDLGLNEIGQelTGQEWRG 455
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSnltnlesLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPEPLGN 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 456 LDNIVEIYLSYNKYLELTtNSFTSVPSLQRLMLRRVALKNVdcsPSPFRPLPNLVILDLSNNNIANINDELlKGLEKLEI 535
Cdd:COG4886 158 LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLET 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 536 LDLQHNNLARLwkhanpggpvQFLKGLFHLHILNLGSNGFDEIPVEAfkDLRELKSIDLGMNNLNILPQSVFDNQVSLKS 615
Cdd:COG4886 233 LDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 56710323 616 LSLQKNLITSVQKTVFGPAFRNLSYLDMRFNPFDCTCESIAWFVNWINITHT 667
Cdd:COG4886 301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 73-543 6.92e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.96  E-value: 6.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   73 TRYSQLTTLD-GGFNSISKLEPELCQsLPWLEILNLQHNEIS-QLSDKTFIFCMNLTELHLMSNSIQKikNDPFKNLKNL 150
Cdd:PLN00113  66 NNSSRVVSIDlSGKNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG--SIPRGSIPNL 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  151 IKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPGEFDFLgnSSLKRLELSSNQIKEFSPGCFHTLGELSGLSLn 230
Cdd:PLN00113 143 ETLDLS------------------------NNMLSGEIPNDIGSF--SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTL- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  231 nakLSPSLTEKLCLELSNT-SIENLSLSSNQLDTISHTTFDGLkqTNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYN 309
Cdd:PLN00113 196 ---ASNQLVGQIPRELGQMkSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  310 NIEHLSSRSFYGLSNLRRLDLRRSFTRQSIsltslPKIddfsFQWLKCLEYLNMDDNNFPGIKRNTFTGLVRLKFLSLSN 389
Cdd:PLN00113 271 KLSGPIPPSIFSLQKLISLDLSDNSLSGEI-----PEL----VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWS 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  390 sfsslRTLTNETFLSLAG-CPLLLLDLTKNKIS-KIQSGAFSwLGHLEVLDLGLNEIGQE-------------------- 447
Cdd:PLN00113 342 -----NKFSGEIPKNLGKhNNLTVLDLSTNNLTgEIPEGLCS-SGNLFKLILFSNSLEGEipkslgacrslrrvrlqdns 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  448 LTGQEWRGLDNIVEIYlsynkYLELTTNSFT--------SVPSLQRLMLRRVA-------------LKNVDCS------- 499
Cdd:PLN00113 416 FSGELPSEFTKLPLVY-----FLDISNNNLQgrinsrkwDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsga 490

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 56710323  500 -PSPFRPLPNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNL 543
Cdd:PLN00113 491 vPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
181-646 5.37e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.37e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 181 NNKISSLTPGEFDFLGNSSLKRLELSSNQIKEFSPGCFHTLGELSGLSLNNAKLSPSLTEKLCLELSNTSIENLSLSSNQ 260
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 261 LDTISHTTFDGLKQTNLTTLDLSrnslrvmGNDSFAWLPHLEYLSLEYNNIEHLSSrSFYGLSNLRRLDLRRSftrqsiS 340
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNN------Q 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 341 LTSLPKiddfSFQWLKCLEYLNMDDNNFPGIKrNTFTGLVRLKFlslsnsfsslrtltnetflslagcplllLDLTKNKI 420
Cdd:COG4886 148 LTDLPE----PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKE----------------------------LDLSNNQI 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 421 SKIqSGAFSWLGHLEVLDLG---LNEIGQELTGqewrgLDNIVEIYLSYNKYLELTtnSFTSVPSLQRLMLRRVALKNVd 497
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSgnqLTDLPEPLAN-----LTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL- 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 498 cspSPFRPLPNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNLARLWKHANPGGPVQFLKGLFHLHILNLGSNGFDE 577
Cdd:COG4886 266 ---PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56710323 578 IPVEAFKDLRELKSIDLGMNNLNILPQSVFDNQVSLKSLSLQKNLITSVQKTVFGPAFRNLSYLDMRFN 646
Cdd:COG4886 343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR_8 pfam13855
Leucine rich repeat;
275-332 1.65e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.65e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 56710323   275 TNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRR 332
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-598 9.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 9.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 133 SNSIQKIKNDPFKNLKNLIKLDLSHNGLSSTKLGTQLQLENLQELLLSNNKISSLTPGEFDFLGNSSLKRLELSSNQIKE 212
Cdd:COG4886   7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 213 FSPGCFHTLGELSGLSLNNAKLSPSLTEKLCLELSNTSIENLSLSSNQLdtishttfdglkqTNLTTLDLSRNSLRVMGn 292
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANL-------------TNLKELDLSNNQLTDLP- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 293 DSFAWLPHLEYLSLEYNNIEHLSSrSFYGLSNLRRLDLRRSftrqsiSLTSLPKiddfSFQWLKCLEYLNMDDNNFPGIK 372
Cdd:COG4886 153 EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN------QITDLPE----PLGNLTNLEELDLSGNQLTDLP 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 373 rntftglvrlkflslsnsfsslrtltnetfLSLAGCP-LLLLDLTKNKISKIQSgaFSWLGHLEVLDLGLNEIGqelTGQ 451
Cdd:COG4886 222 ------------------------------EPLANLTnLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLT---DLP 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 452 EWRGLDNIVEIYLSYNKYLELTTNSFTSVPSLQRL-MLRRVALKNVDCSPSPFRPLPNLVILDLSNNNIANINDELLKGL 530
Cdd:COG4886 267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLlLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56710323 531 EKLEILDLQHNNLARLWKHANPGGPVQFLKGLFHLHILNLGSNGFDEIPVEAFKDLRELKSIDLGMNN 598
Cdd:COG4886 347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 413-541 1.37e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 413 LDLTKNKISKIQSgaFSWLGHLEVLDLGLNEIgQELTGQEwrGLDNIVEIYLSYNK-----YLELTTNSFTSV-PSLQRL 486
Cdd:cd21340  51 LYLQNNQIEKIEN--LENLVNLKKLYLGGNRI-SVVEGLE--NLTNLEELHIENQRlppgeKLTFDPRSLAALsNSLRVL 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56710323 487 MLRRvalKNVDcSPSPFRPLPNLVILDLSNNNIANIND--ELLKGLEKLEILDLQHN 541
Cdd:cd21340 126 NISG---NNID-SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 56-311 8.59e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 8.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   56 VLNLTHNQLRRLPPANFTRYSQLTTLDGGFNSISKLEPE-LCQSlPWLEILNLQHNEISQLSDKTFIFCMNLTELHLMSN 134
Cdd:PLN00113 336 VLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEgLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  135 SIQKIKNDPFKNLKNLIKLDLSHNGLSSTKLGTQLQLENLQELLLSNNKISSLTPgefDFLGNSSLKRLELSSNQIKEFS 214
Cdd:PLN00113 415 SFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLP---DSFGSKRLENLDLSRNQFSGAV 491

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  215 PGCFHTLGELSGLSLNNAKLSPSLTEklclELSNTSienlslssnqldtishttfdglkqtNLTTLDLSRNSLRVMGNDS 294
Cdd:PLN00113 492 PRKLGSLSELMQLKLSENKLSGEIPD----ELSSCK-------------------------KLVSLDLSHNQLSGQIPAS 542

                        250
                 ....*....|....*..
gi 56710323  295 FAWLPHLEYLSLEYNNI 311
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
249-311 1.58e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.58e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56710323   249 TSIENLSLSSNQLDTISHTTFDGLKqtNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYNNI 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-543 1.25e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 1.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   46 IPDDLPTNITVLNLTHNQLRRLPPANFTRYSQLTTLDGGFNSISKLEPELCQSLPWLEILNLQHNEISQLSDKTFIFCMN 125
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  126 LTELHLMSNSIQKIKNDPFKNLKNLIKLDLSHNGLSSTKLGTQLQLENLQELLLSNNKIS-SLTPGEFDFlgnSSLKRLE 204
Cdd:PLN00113 214 LKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSL---QKLISLD 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  205 LSSNQIKEFSPGCFHTLGELSGLSLNNAKLSPSLTEKLClelSNTSIENLSLSSNQLDtiSHTTFDGLKQTNLTTLDLSR 284
Cdd:PLN00113 291 LSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALT---SLPRLQVLQLWSNKFS--GEIPKNLGKHNNLTVLDLST 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  285 NSLRVMGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLrrsftrQSISLT-SLPKiddfSFQWLKCLEYLNM 363
Cdd:PLN00113 366 NNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRL------QDNSFSgELPS----EFTKLPLVYFLDI 435

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  364 DDNNFPGikrntftglvRLKFLSLSNSFSSLRTLTNETFL-----SLAGCPLLLLDLTKNKISKIQSGAFSWLGHLEVLD 438
Cdd:PLN00113 436 SNNNLQG----------RINSRKWDMPSLQMLSLARNKFFgglpdSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLK 505

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  439 LGLNEIGQELTgQEWRGLDNIVEIYLSYNKyleLTTNSftsvpslqrlmlrrvalknvdcsPSPFRPLPNLVILDLSNNN 518
Cdd:PLN00113 506 LSENKLSGEIP-DELSSCKKLVSLDLSHNQ---LSGQI-----------------------PASFSEMPVLSQLDLSQNQ 558

                        490       500
                 ....*....|....*....|....*
gi 56710323  519 IANINDELLKGLEKLEILDLQHNNL 543
Cdd:PLN00113 559 LSGEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
481-543 1.46e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56710323   481 PSLQRLMLRRVALKNVDcsPSPFRPLPNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNL 543
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-208 6.68e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 6.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  38 CSHLKLTQIPD-DLPTNITVLNLTHNQLRRLPpaNFTRYSQLTTLDGGFNSISKLEPElcQSLPWLEILNLQHNEISQLS 116
Cdd:cd21340   9 LNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRISVVE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 117 --DKtfifCMNLTELHLMSNSI---QKIKNDPFKNL---KNLIKLDLSHNGLSStkLGTQLQLENLQELLLSNNKISSLT 188
Cdd:cd21340  85 glEN----LTNLEELHIENQRLppgEKLTFDPRSLAalsNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                       170       180
                ....*....|....*....|
gi 56710323 189 PGEFDFLGNSSLKRLELSSN 208
Cdd:cd21340 159 ELLDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 434-648 1.16e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.67  E-value: 1.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 434 LEVLDLGLNEIGQELTG-----QEWRGLDNIVEIYLSYNKYLELTTN---SFTSVPSLQRLMLRR-----VALKNVDCSP 500
Cdd:cd00116  53 LKELCLSLNETGRIPRGlqsllQGLTKGCGLQELDLSDNALGPDGCGvleSLLRSSSLQELKLNNnglgdRGLRLLAKGL 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 501 SPfrPLPNLVILDLSNNNIANINDE----LLKGLEKLEILDLQHNNL----ARLWKHAnpggpvqfLKGLFHLHILNLGS 572
Cdd:cd00116 133 KD--LPPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIgdagIRALAEG--------LKANCNLEVLDLNN 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 573 NGFDEIPV----EAFKDLRELKSIDLGMNNLNILPQSVFDNQV-----SLKSLSLQKNLIT---SVQKTVFGPAFRNLSY 640
Cdd:cd00116 203 NGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGAAALASALlspniSLLTLSLSCNDITddgAKDLAEVLAEKESLLE 282


                ....*...
gi 56710323 641 LDMRFNPF 648
Cdd:cd00116 283 LDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
564-623 2.43e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.43e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   564 HLHILNLGSNGFDEIPVEAFKDLRELKSIDLGMNNLNILPQSVFDNQVSLKSLSLQKNLI 623
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
125-210 2.79e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   125 NLTELHLMSNSIQKIKNDPFKNLKNLIKLDLSHnglsstklgtqlqlenlqelllsnNKISSLTPGEFDFLgnSSLKRLE 204
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSN------------------------NLLTTLSPGAFSGL--PSLRYLD 55


                  ....*.
gi 56710323   205 LSSNQI 210
Cdd:pfam13855  56 LSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-285 3.31e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 3.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  84 GFNSISKLEpeLCQSLpwlEILNLQHNEISQLSDktFIFCMNLTELHLMSNSIQKIKNdpFKNLKNLIKLDLSHNGLSst 163
Cdd:cd21340  13 NITKIDNLS--LCKNL---KVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 164 klgtqlqlenlqelllsnnKISSLTpgefdflGNSSLKRLELSSNQIKE-----FSPGCFHTLGE-LSGLSLNNAKLSpS 237
Cdd:cd21340  82 -------------------VVEGLE-------NLTNLEELHIENQRLPPgekltFDPRSLAALSNsLRVLNISGNNID-S 134

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 56710323 238 LTEKLCLelsnTSIENLSLSSNQLDTISHTTFDGLKQTNLTTLDLSRN 285
Cdd:cd21340 135 LEPLAPL----RNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
52-112 1.31e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.31e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56710323    52 TNITVLNLTHNQLRRLPPANFTRYSQLTTLDGGFNSISKLEPELCQSLPWLEILNLQHNEI 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-314 1.65e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   41 LKLTQIPDDLPTNITVLNLTHNQLRRLPPanfTRYSQLTTLDGGFNSISKLePElcqSLP-WLEILNLQHNEISQLSDkt 119
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSI-PA---TLPdTIQEMELSINRITELPE-- 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  120 fifcmnltelHLMSnsiqkikndpfknlkNLIKLDLSHNGLSSTKlgtQLQLENLQELLLSNNKISSLtPGEFDflgnSS 199
Cdd:PRK15370 259 ----------RLPS---------------ALQSLDLFHNKISCLP---ENLPEELRYLSVYDNSIRTL-PAHLP----SG 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  200 LKRLELSSNQIKeFSPGCFHTlgELSGLSLNNAKLSpSLTEKLCLELsntsiENLSLSSNQLDTISHTtfdgLKQTnLTT 279
Cdd:PRK15370 306 ITHLNVQSNSLT-ALPETLPP--GLKTLEAGENALT-SLPASLPPEL-----QVLDVSKNQITVLPET----LPPT-ITT 371

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 56710323  280 LDLSRNSLRVMGNDsfawLP-HLEYLSLEYNNIEHL 314
Cdd:PRK15370 372 LDVSRNALTNLPEN----LPaALQIMQASRNNLVRL 403
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 787-880 2.42e-06

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 48.51  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   787 CLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCkRFKVHHAVQQAIEQNLdSIILIFLEEIPDYKLNHALCL 866
Cdd:pfam01582  32 FIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWC-LDELVKILECALDLGQ-KVIPIFYEVDPSDVRKQTGSF 109

                          90       100
                  ....*....|....*....|.
gi 56710323   867 RRGmFKSHC-------ILNWP 880
Cdd:pfam01582 110 GKA-FKKHKkvlteekVLKWR 129
LRR_8 pfam13855
Leucine rich repeat;
102-160 2.56e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.56e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 56710323   102 LEILNLQHNEISQLSDKTFIFCMNLTELHLMSNSIQKIKNDPFKNLKNLIKLDLSHNGL 160
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 197-452 2.76e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 2.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 197 NSSLKRLELSSNQIKEFSPG---CFHTLGELSGL---SLNNAKLSPSLTEKLCLELSNTSIENLSLSSNQL-DTISHTTF 269
Cdd:cd00116  50 QPSLKELCLSLNETGRIPRGlqsLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLgDRGLRLLA 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 270 DGLK--QTNLTTLDLSRNSLRvmGNDSFAW---LPH---LEYLSLEYNN-----IEHLsSRSFYGLSNLRRLDLRRS-FT 335
Cdd:cd00116 130 KGLKdlPPALEKLVLGRNRLE--GASCEALakaLRAnrdLKELNLANNGigdagIRAL-AEGLKANCNLEVLDLNNNgLT 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 336 RQSISLTSLpkiddfSFQWLKCLEYLNMDDNNFpgikrnTFTGLVRLKflslsnsfsslrtltnETFLSLAGCpLLLLDL 415
Cdd:cd00116 207 DEGASALAE------TLASLKSLEVLNLGDNNL------TDAGAAALA----------------SALLSPNIS-LLTLSL 257

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56710323 416 TKNKISkiQSGAFSWLG------HLEVLDLGLNEIGQELTGQE 452
Cdd:cd00116 258 SCNDIT--DDGAKDLAEvlaekeSLLELDLRGNKFGEEGAQLL 298
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 699-731 6.71e-06

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


Pssm-ID: 465595  Cd Length: 33  Bit Score: 43.45  E-value: 6.71e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 56710323   699 DSAPFELLFMININILLIFIFIVLLIHFEGWRI 731
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
LRR_8 pfam13855
Leucine rich repeat;
76-136 1.09e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56710323    76 SQLTTLDGGFNSISKLEPELCQSLPWLEILNLQHNEISQLSDKTFIFCMNLTELHLMSNSI 136
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
413-468 1.95e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.95e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 56710323   413 LDLTKNKISKIQSGAFSWLGHLEVLDLGLNEIgQELTGQEWRGLDNIVEIYLSYNK 468
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
468-692 2.49e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 2.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  468 KYLELTTNSFTSVPSLQRLMLRRVALKNVDCSPSPFRpLPN-LVILDLSNNNIANINDELLKGLEKLEILDlqhNNLARL 546
Cdd:PRK15370 223 KTLYANSNQLTSIPATLPDTIQEMELSINRITELPER-LPSaLQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTL 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  547 WKHAnPGGPVQ---------FLKGLF--HLHILNLGSNGFDEIPvEAFKDlrELKSIDLGMNNLNILPQSVfdnQVSLKS 615
Cdd:PRK15370 299 PAHL-PSGITHlnvqsnsltALPETLppGLKTLEAGENALTSLP-ASLPP--ELQVLDVSKNQITVLPETL---PPTITT 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  616 LSLQKNLITSVQKTVfgPAfrNLSYLDMRFNPFDCTCESIAWFVN------WINITHTNISE--LSNHYLCNTPPQYHGy 687
Cdd:PRK15370 372 LDVSRNALTNLPENL--PA--ALQIMQASRNNLVRLPESLPHFRGegpqptRIIVEYNPFSErtIQNMQRLMSSVGYQG- 446


                 ....*
gi 56710323  688 PVMLF 692
Cdd:PRK15370 447 PRVLF 451
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 249-368 5.10e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 5.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 249 TSIENLS---------LSSNQLDTISHTTFdglkQTNLTTLDLSRNSLRVMGNdsFAWLPHLEYLSLEYNNIEHLSsrSF 319
Cdd:cd21340  15 TKIDNLSlcknlkvlyLYDNKITKIENLEF----LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE--GL 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56710323 320 YGLSNLR-------RLDLRRSFTRQSISLTSLP-----------KIDDFS-FQWLKCLEYLNMDDNNF 368
Cdd:cd21340  87 ENLTNLEelhienqRLPPGEKLTFDPRSLAALSnslrvlnisgnNIDSLEpLAPLRNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 503-628 6.84e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 6.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 503 FRPLPNLVILDLSNNNIANIndELLKGLEKLEILDLQHNNLArlwkhanPGGPVQF----LKGLFH-LHILNLGSNGFDE 577
Cdd:cd21340  64 LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLP-------PGEKLTFdprsLAALSNsLRVLNISGNNIDS 134

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 56710323 578 IpvEAFKDLRELKSIDLGMNNLNILPQ--SVFDNQVSLKSLSLQKNLITSVQK 628
Cdd:cd21340 135 L--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
507-599 1.22e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   507 PNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNLarlwkhanpggpvqflkglfhlhilnlgsngfDEIPVEAFKDL 586
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--------------------------------TTLSPGAFSGL 48

                          90
                  ....*....|...
gi 56710323   587 RELKSIDLGMNNL 599
Cdd:pfam13855  49 PSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
646-698 3.17e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 3.17e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56710323    646 NPFDCTCEsIAWFVNWINitHTNISELSNHYLCNTPPQYHGyPV--MLFDVSPCK 698
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQ--ANEHLQDPVDLRCASPSSLRG-PLleLLHSEFKCP 51
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 31-309 3.61e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 3.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  31 VRHEVADCSHLKltQIPDDLPTN--ITVLNLTHNQLRRLPPA------NFTRYSQLTTLDGGFNSISKLEPELCQSL--- 99
Cdd:cd00116  30 LEGNTLGEEAAK--ALASALRPQpsLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESLlrs 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 100 PWLEILNLQHNEISQlsDKTFIFCMNLTELHLmsnsiqkikndpfknlkNLIKLDLSHNGLSSTklgtqlqlenlqelll 179
Cdd:cd00116 108 SSLQELKLNNNGLGD--RGLRLLAKGLKDLPP-----------------ALEKLVLGRNRLEGA---------------- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323 180 snnkisSLTPGEFDFLGNSSLKRLELSSNQIKEFSpgcFHTLGE-------LSGLSLNNAKLSPSLTEKLCLEL-SNTSI 251
Cdd:cd00116 153 ------SCEALAKALRANRDLKELNLANNGIGDAG---IRALAEglkancnLEVLDLNNNGLTDEGASALAETLaSLKSL 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56710323 252 ENLSLSSNQL-DTISHTTFDGLKQTN--LTTLDLSRNSLRVMGNDSFAWL----PHLEYLSLEYN 309
Cdd:cd00116 224 EVLNLGDNNLtDAGAAALASALLSPNisLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGN 288
LRR_8 pfam13855
Leucine rich repeat;
587-648 4.85e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.85e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56710323   587 RELKSIDLGMNNLNILPQSVFDNQVSLKSLSLQKNLITSVQKTVFGPaFRNLSYLDMRFNPF 648
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG-LPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 507-543 5.43e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 5.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 56710323   507 PNLVILDLSNNNIANIndELLKGLEKLEILDLQHNNL 543
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 45-113 7.02e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 7.02e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56710323   45 QIPDDLPT--NITVLNLTHNQLRRLPPANFTRYSQLTTLDGGFNSISKLEPELCQSLPWLEILNLQHNEIS 113
Cdd:PLN03150 433 FIPNDISKlrHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 618-690 9.98e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.15  E-value: 9.98e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56710323    618 LQKNLITSVQKTVFGPAFrNLSYLDMRFNPFDCTCeSIAWFVNWINITHTNISElSNHYLCNTPPQYHGYPVM 690
Cdd:TIGR00864    2 ISNNKISTIEEGICANLC-NLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVRQ-PEAALCAGPGALAGQPLL 71
LRR_8 pfam13855
Leucine rich repeat;
180-231 1.20e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 56710323   180 SNNKISSLTPGEFdfLGNSSLKRLELSSNQIKEFSPGCFHTLGELSGLSLNN 231
Cdd:pfam13855   9 SNNRLTSLDDGAF--KGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 247-376 1.51e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   247 SNTSIENLSLSSNqLDTISHTTFDGLkqTNLTTLDLSrNSLRVMGNDSFAWLPhLEYLSLEyNNIEHLSSRSFYGLSNLR 326
Cdd:pfam13306   9 YNCSLTSITIPSS-LTSIGEYAFSNC--TSLKSITLP-SSLTSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCSNLK 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 56710323   327 RLDLRRSFTrqsisltslpKIDDFSFQwlKC-LEYLNMDDNNFPgIKRNTF 376
Cdd:pfam13306  83 SITLPSNLT----------SIGSYAFS--NCsLKSITIPSSVTT-IGSYAF 120
LRR_8 pfam13855
Leucine rich repeat;
198-287 2.61e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   198 SSLKRLELSSNQIKEFSPGCFHTLgelsglslnnaklsPSLTEklclelsntsienLSLSSNQLDTISHTTFDGLKqtNL 277
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGL--------------SNLKV-------------LDLSNNLLTTLSPGAFSGLP--SL 51

                          90
                  ....*....|
gi 56710323   278 TTLDLSRNSL 287
Cdd:pfam13855  52 RYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 197-326 4.06e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.29  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   197 NSSLKRLELSSNqIKEFSPGCFhtlgelSG-LSLNNAKLSPSLTEklcLE---LSNTSIENLSLSSNqLDTISHTTFDGL 272
Cdd:pfam13306  10 NCSLTSITIPSS-LTSIGEYAF------SNcTSLKSITLPSSLTS---IGsyaFYNCSLTSITIPSS-LTSIGEYAFSNC 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 56710323   273 kqTNLTTLDLSrNSLRVMGNDSFAwlphleYLSLEY----NNIEHLSSRSFYGLSNLR 326
Cdd:pfam13306  79 --SNLKSITLP-SNLTSIGSYAFS------NCSLKSitipSSVTTIGSYAFSNCSNLK 127
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 13-161 4.52e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   13 SGLLTCWILCTSSAHKcTVRHEVADCSHLKLTQIPD-----DLPTNIT------VLNLTHNQLRRLPPANFTRYSQLTTL 81
Cdd:PLN00113 379 SGNLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDnsfsgELPSEFTklplvyFLDISNNNLQGRINSRKWDMPSLQML 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   82 DGGFNSISKLEPELCQSlPWLEILNLQHNEISQLSDKTFIFCMNLTELHLMSNSIQKIKNDPFKNLKNLIKLDLSHNGLS 161
Cdd:PLN00113 458 SLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 275-621 7.09e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 7.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  275 TNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYNNIE-HLSSRSFYGLSNLRRLDLRRSFTRQSISLTSLPkiddfsfq 353
Cdd:PLN00113  69 SRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP-------- 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  354 wlkCLEYLNMDDNNFPGIKRN---TFTGLVRLKFLSLSNSFSSLRTLTNET---FLSLA------GCP--------LLLL 413
Cdd:PLN00113 141 ---NLETLDLSNNMLSGEIPNdigSFSSLKVLDLGGNVLVGKIPNSLTNLTsleFLTLAsnqlvgQIPrelgqmksLKWI 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  414 DLTKNKIS---KIQSGAFSWLGHLevlDLGLNEigqeLTGQEWRGLDNiveiyLSYNKYLELTTNSFT-----SVPSLQR 485
Cdd:PLN00113 218 YLGYNNLSgeiPYEIGGLTSLNHL---DLVYNN----LTGPIPSSLGN-----LKNLQYLFLYQNKLSgpippSIFSLQK 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323  486 LmlrrVALKNVDCSPSPFRP-----LPNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNL-----ARLWKHANpggp 555
Cdd:PLN00113 286 L----ISLDLSDNSLSGEIPelviqLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFsgeipKNLGKHNN---- 357

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56710323  556 vqflkglfhLHILNLGSNGFD-EIPvEAFKDLRELKSIDLGMNNLN-ILPQSVFDNQvSLKSLSLQKN 621
Cdd:PLN00113 358 ---------LTVLDLSTNNLTgEIP-EGLCSSGNLFKLILFSNSLEgEIPKSLGACR-SLRRVRLQDN 414
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 759-852 7.41e-03

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 37.29  E-value: 7.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56710323   759 YIIHAYKDRDWVwkhsspmED-----EDHTLRFCLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCKRfkvh 833
Cdd:pfam13676   2 FISYAGEDRAWA-------EWladalEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRA---- 70

                          90
                  ....*....|....*....
gi 56710323   834 hAVQQAIEQNLDSIILIFL 852
Cdd:pfam13676  71 -EWEAALADPEGRKRLIPV 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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