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    MAP2 microtubule associated protein 2 [ Homo sapiens (human) ]

    Gene ID: 4133, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MAP2provided by HGNC
    Official Full Name
    microtubule associated protein 2provided by HGNC
    Primary source
    HGNC:HGNC:6839
    See related
    Ensembl:ENSG00000078018 MIM:157130; AllianceGenome:HGNC:6839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAP-2; MAP2A; MAP2B; MAP2C
    Summary
    This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
    Expression
    Biased expression in brain (RPKM 82.4), thyroid (RPKM 4.7) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See MAP2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (209424047..209734112)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (209904237..210214222)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (210288771..210598836)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MYST/Esa1-associated factor 6 pseudogene 1 Neighboring gene plakophilin 4 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:210163633-210164292 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:210164293-210164952 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:210168954-210169953 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:210169954-210170952 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:210233444-210234643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12291 Neighboring gene NANOG hESC enhancer GRCh37_chr2:210315845-210316346 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:210359703-210360902 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:210383815-210384500 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:210479322-210479919 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:210479920-210480516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:210616149-210616706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:210616707-210617263 Neighboring gene RNA, 5S ribosomal pseudogene 118 Neighboring gene NANOG hESC enhancer GRCh37_chr2:210638115-210638616 Neighboring gene Sharpr-MPRA regulatory region 8450 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:210729225-210729762 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:210729763-210730300 Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene Sharpr-MPRA regulatory region 8902 Neighboring gene snail family zinc finger 1 pseudogene 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:210782411-210783610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17054 Neighboring gene KAT8 regulatory NSL complex subunit 1 like Neighboring gene ribulose-5-phosphate-3-epimerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MAP-2 immunoexpression in gliomatosis cerebri. Romeike BF, et al. Histopathology, 2009 Mar. PMID 19309409
    2. Circ_001680 aggravates the malignant process of gastric carcinoma by targeting MAP2. Zhao HD, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32572922
    3. Specific binding of dehydroepiandrosterone to the N terminus of the microtubule-associated protein MAP2. Laurine E, et al. J Biol Chem, 2003 Aug 8. PMID 12775713
    4. Microtubule-associated protein 2 knockdown sensitizes glioma cells to vincristine treatment. Yang L, et al. Neuroreport, 2020 Feb 5. PMID 31834144
    5. Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles. Lauckner J, et al. Neurobiol Aging, 2003 Oct. PMID 12927759

    See all (152) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains.
      Title: Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains.
    2. MAP2 caps tau fibrils and inhibits aggregation.
      Title: MAP2 caps tau fibrils and inhibits aggregation.
    3. Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.
      Title: Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.
    4. Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions.
      Title: Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions.
    5. Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2.
      Title: Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2.
    6. Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2.
      Title: Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2.
    7. Angiotensin II Induces Differentiation of Human Neuroblastoma Cells by Increasing MAP2 and ROS Levels.
      Title: Angiotensin II Induces Differentiation of Human Neuroblastoma Cells by Increasing MAP2 and ROS Levels.
    8. The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients.
      Title: The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients.
    9. Circ_001680 aggravates the malignant process of gastric carcinoma by targeting MAP2.
      Title: Circ_001680 aggravates the malignant process of gastric carcinoma by targeting MAP2.
    10. Microtubule alterations may destabilize photoreceptor integrity: Age-related microtubule changes and pattern of expression of MAP-2, Tau and hyperphosphorylated Tau in aging human photoreceptor cells.
      Title: Microtubule alterations may destabilize photoreceptor integrity: Age-related microtubule changes and pattern of expression of MAP-2, Tau and hyperphosphorylated Tau in aging human photoreceptor cells.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120/MBL complex co-localizes with MAP2 and is transported along the microtubules in human primary neurons PubMed
    env Ascorbate supplementation prevents the deleterious upregulation of iNOS and associated neuronal (MAP2) and astrocytic (GFAP) protein expression and structural changes caused by gp120 in human brain cell cultures PubMed
    Tat tat HIV-1 Tat co-localizes with microtubule-associated protein 2 in neuronal cells PubMed
    tat HIV-1 Tat downregulates expression of MAP2 in human microglia and neuroblastoma cells PubMed
    retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686I2148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dystroglycan binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables tau protein binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system neuron development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in dendrite development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of anterograde dense core granule transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of anterograde synaptic vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of microtubule polymerization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of organelle transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical distal dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in axon hillock ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in axon initial segment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in basal dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic branch ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in distal dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT located_in main axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of microtubule associated complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in primary dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in proximal dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in proximal neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052836.1 RefSeqGene

      Range
      5001..315066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039538.2 → NP_001034627.1  microtubule-associated protein 2 isoform 5

      See identical proteins and their annotated locations for NP_001034627.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and includes an alternate in-frame exon, compared to variant 2, resulting in a longer protein (isoform 5), compared to isoform 2.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      Consensus CDS
      CCDS33369.1
      UniProtKB/TrEMBL
      Q59FX9
      Related
      ENSP00000199940.6, ENST00000199940.10
      Conserved Domains (2) summary
      PTZ00449
      Location:175 → 389
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:393 → 422
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    2. NM_001363910.2 → NP_001350839.1  microtubule-associated protein 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in 5' UTR and includes three alternate in-frame exons compared to variant 2. It encodes a longer protein (isoform 6) compared to isoform 2. Variants 6 and 7 encode the same isoform (6).
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      Consensus CDS
      CCDS86916.1
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1444 → 1684
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1688 → 1717
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1501
      MAP2_projctn; MAP2/Tau projection domain

    3. NM_001363911.2 → NP_001350840.1  microtubule-associated protein 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) includes three alternate in-frame exons compared to variant 2. It encodes a longer protein (isoform 6) compared to isoform 2. Variants 6 and 7 encode the same isoform (6).
      Source sequence(s)
      AC006385, AC079833, AC108072
      Consensus CDS
      CCDS86916.1
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1444 → 1684
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1688 → 1717
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1501
      MAP2_projctn; MAP2/Tau projection domain

    4. NM_001363913.2 → NP_001350842.1  microtubule-associated protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 2. Variants 2, 8, 11, and 60 all encode the same isoform (2).
      Source sequence(s)
      AC006385, AC079833, AC108072
      Consensus CDS
      CCDS2385.1
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Related
      ENSP00000376032.1, ENST00000392194.5
      Conserved Domains (1) summary
      pfam00418
      Location:367 → 398
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    5. NM_001375474.1 → NP_001362403.1  microtubule-associated protein 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (2) summary
      PTZ00449
      Location:175 → 389
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:393 → 422
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    6. NM_001375493.1 → NP_001362422.1  microtubule-associated protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 2, 8, and 60, encodes isoform 2.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      Consensus CDS
      CCDS2385.1
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Conserved Domains (1) summary
      pfam00418
      Location:367 → 398
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    7. NM_001375494.1 → NP_001362423.1  microtubule-associated protein 2 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      Conserved Domains (1) summary
      pfam00418
      Location:304 → 334
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    8. NM_001375495.1 → NP_001362424.1  microtubule-associated protein 2 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (42), as well as variants 43 and 44, encodes isoform 20.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (3) summary
      PTZ00449
      Location:206 → 446
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:450 → 479
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:151 → 263
      MAP2_projctn; MAP2/Tau projection domain

    9. NM_001375496.1 → NP_001362425.1  microtubule-associated protein 2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (2) summary
      PTZ00449
      Location:174 → 388
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:392 → 421
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    10. NM_001375497.1 → NP_001362426.1  microtubule-associated protein 2 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (55), as well as variants 51 and 54, encodes isoform 27.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Conserved Domains (1) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    11. NM_001375498.1 → NP_001362427.1  microtubule-associated protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (3) summary
      PTZ00449
      Location:149 → 444
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:448 → 477
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:150 → 262
      MAP2_projctn; MAP2/Tau projection domain

    12. NM_001375499.1 → NP_001362428.1  microtubule-associated protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 4 and 15, encodes isoform 4.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (2) summary
      PHA03247
      Location:176 → 306
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:336 → 365
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    13. NM_001375500.1 → NP_001362429.1  microtubule-associated protein 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1444 → 1684
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1660 → 1686
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1501
      MAP2_projctn; MAP2/Tau projection domain

    14. NM_001375501.1 → NP_001362430.1  microtubule-associated protein 2 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variant 18, encodes isoform 8.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1530 → 1770
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:459 → 1587
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:1805 → 1836
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    15. NM_001375502.1 → NP_001362431.1  microtubule-associated protein 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1447 → 1687
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1691 → 1720
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:376 → 1504
      MAP2_projctn; MAP2/Tau projection domain

    16. NM_001375503.1 → NP_001362432.1  microtubule-associated protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (4) summary
      PTZ00121
      Location:84 → 354
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:1525 → 1764
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1768 → 1797
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:454 → 1581
      MAP2_projctn; MAP2/Tau projection domain

    17. NM_001375504.1 → NP_001362433.1  microtubule-associated protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1531 → 1745
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1749 → 1778
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain

    18. NM_001375505.1 → NP_001362434.1  microtubule-associated protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (67), as well as variants 1, 9, and 10, encodes isoform 1.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      Consensus CDS
      CCDS2384.1
      UniProtKB/Swiss-Prot
      P11137, Q17S04, Q8IUX2, Q99975, Q99976
      UniProtKB/TrEMBL
      A0A669KB77
      Related
      ENSP00000507035.1, ENST00000682079.1
      Conserved Domains (3) summary
      PTZ00449
      Location:1448 → 1688
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1692 → 1721
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain

    19. NM_001375506.1 → NP_001362435.1  microtubule-associated protein 2 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variant 23, encodes isoform 12.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1407 → 1687
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1691 → 1720
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain

    20. NM_001375507.1 → NP_001362436.1  microtubule-associated protein 2 isoform 14

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variant 28, encodes isoform 14.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1444 → 1683
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1687 → 1716
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1500
      MAP2_projctn; MAP2/Tau projection domain

    21. NM_001375508.1 → NP_001362437.1  microtubule-associated protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 4 and 14, encodes isoform 4.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (2) summary
      PHA03247
      Location:176 → 306
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:336 → 365
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    22. NM_001375509.1 → NP_001362438.1  microtubule-associated protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (3) summary
      PTZ00449
      Location:166 → 407
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:411 → 440
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:169 → 224
      MAP2_projctn; MAP2/Tau projection domain

    23. NM_001375510.1 → NP_001362439.1  microtubule-associated protein 2 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (43), as well as variants 42 and 44, encodes isoform 20.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (3) summary
      PTZ00449
      Location:206 → 446
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:450 → 479
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:151 → 263
      MAP2_projctn; MAP2/Tau projection domain

    24. NM_001375526.1 → NP_001362455.1  microtubule-associated protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 10, and 67, encodes isoform 1.
      Source sequence(s)
      AC006385, AC079833, AC108072
      Consensus CDS
      CCDS2384.1
      UniProtKB/Swiss-Prot
      P11137, Q17S04, Q8IUX2, Q99975, Q99976
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1448 → 1688
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1692 → 1721
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain

    25. NM_001375527.1 → NP_001362456.1  microtubule-associated protein 2 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variant 26, encodes isoform 12.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1407 → 1687
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1691 → 1720
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain

    26. NM_001375528.1 → NP_001362457.1  microtubule-associated protein 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 6 and 7, encodes isoform 6.
      Source sequence(s)
      AC006385, AC079833, AC108072
      Consensus CDS
      CCDS86916.1
      UniProtKB/TrEMBL
      A0A669KB77
      Related
      ENSP00000392164.1, ENST00000447185.5
      Conserved Domains (3) summary
      PTZ00449
      Location:1444 → 1684
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1688 → 1717
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1501
      MAP2_projctn; MAP2/Tau projection domain

    27. NM_001375529.1 → NP_001362458.1  microtubule-associated protein 2 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (51), as well as variants 54 and 55, encodes isoform 27.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Conserved Domains (1) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    28. NM_001375530.1 → NP_001362459.1  microtubule-associated protein 2 isoform 36

      Status: REVIEWED

      Description
      Transcript Variant: This variant (52), as well as variant 53, encodes isoform 36.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Conserved Domains (1) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    29. NM_001375531.1 → NP_001362460.1  microtubule-associated protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1489 → 1769
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1773 → 1802
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:459 → 1587
      MAP2_projctn; MAP2/Tau projection domain

    30. NM_001375532.1 → NP_001362461.1  microtubule-associated protein 2 isoform 36

      Status: REVIEWED

      Description
      Transcript Variant: This variant (53), as well as variant 52, encodes isoform 36.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Conserved Domains (1) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    31. NM_001375533.1 → NP_001362462.1  microtubule-associated protein 2 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (54), as well as variants 51 and 55, encodes isoform 27.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Conserved Domains (1) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    32. NM_001375534.1 → NP_001362463.1  microtubule-associated protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 9, and 67, encodes isoform 1.
      Source sequence(s)
      AC006385, AC079833, AC108072
      Consensus CDS
      CCDS2384.1
      UniProtKB/Swiss-Prot
      P11137, Q17S04, Q8IUX2, Q99975, Q99976
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1448 → 1688
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1692 → 1721
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain

    33. NM_001375535.1 → NP_001362464.1  microtubule-associated protein 2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (2) summary
      PTZ00449
      Location:170 → 413
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:417 → 446
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    34. NM_001375536.1 → NP_001362465.1  microtubule-associated protein 2 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (44), as well as variants 42 and 43, encodes isoform 20.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (3) summary
      PTZ00449
      Location:206 → 446
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:450 → 479
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:151 → 263
      MAP2_projctn; MAP2/Tau projection domain

    35. NM_001375537.1 → NP_001362466.1  microtubule-associated protein 2 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 19, encodes isoform 8.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Related
      ENSP00000501117.1, ENST00000673860.1
      Conserved Domains (3) summary
      PTZ00449
      Location:1530 → 1770
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:459 → 1587
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:1805 → 1836
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    36. NM_001375538.1 → NP_001362467.1  microtubule-associated protein 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (3) summary
      PTZ00449
      Location:206 → 445
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:449 → 478
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:151 → 262
      MAP2_projctn; MAP2/Tau projection domain

    37. NM_001375539.1 → NP_001362468.1  microtubule-associated protein 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (4) summary
      PTZ00121
      Location:84 → 355
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:1526 → 1766
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1770 → 1799
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:455 → 1583
      MAP2_projctn; MAP2/Tau projection domain

    38. NM_001375540.1 → NP_001362469.1  microtubule-associated protein 2 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (3) summary
      PTZ00449
      Location:205 → 444
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:448 → 477
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:150 → 261
      MAP2_projctn; MAP2/Tau projection domain

    39. NM_001375541.1 → NP_001362470.1  microtubule-associated protein 2 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (3) summary
      PTZ00449
      Location:155 → 377
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:381 → 410
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:143 → 194
      MAP2_projctn; MAP2/Tau projection domain

    40. NM_001375542.1 → NP_001362471.1  microtubule-associated protein 2 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Conserved Domains (1) summary
      pfam00418
      Location:334 → 363
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    41. NM_001375543.1 → NP_001362472.1  microtubule-associated protein 2 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1448 → 1687
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1691 → 1720
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1504
      MAP2_projctn; MAP2/Tau projection domain

    42. NM_001375544.1 → NP_001362473.1  microtubule-associated protein 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1447 → 1687
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1691 → 1720
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:376 → 1504
      MAP2_projctn; MAP2/Tau projection domain

    43. NM_001375545.1 → NP_001362474.1  microtubule-associated protein 2 isoform 14

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variant 32, encodes isoform 14.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1444 → 1683
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1687 → 1716
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1500
      MAP2_projctn; MAP2/Tau projection domain

    44. NM_001375546.1 → NP_001362475.1  microtubule-associated protein 2 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1403 → 1683
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1687 → 1716
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1501
      MAP2_projctn; MAP2/Tau projection domain

    45. NM_001375548.1 → NP_001362477.1  microtubule-associated protein 2 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1443 → 1683
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1687 → 1716
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:372 → 1500
      MAP2_projctn; MAP2/Tau projection domain

    46. NM_001375551.1 → NP_001362480.1  microtubule-associated protein 2 isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (36), as well as variants 12, 34, and 35, encodes isoform 16.
      Source sequence(s)
      AC006385, AC079833
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1290 → 1530
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1534 → 1563
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:219 → 1347
      MAP2_projctn; MAP2/Tau projection domain

    47. NM_001375552.1 → NP_001362481.1  microtubule-associated protein 2 isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 34, 35, and 36, encodes isoform 16.
      Source sequence(s)
      AC006385, AC079833
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1290 → 1530
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1534 → 1563
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:219 → 1347
      MAP2_projctn; MAP2/Tau projection domain

    48. NM_001375553.1 → NP_001362482.1  microtubule-associated protein 2 isoform 29

      Status: REVIEWED

      Description
      Transcript Variant: This variant (57), as well as variant 58, encodes isoform 29.
      Source sequence(s)
      AC006385, AC079833
      Conserved Domains (3) summary
      PTZ00449
      Location:49 → 289
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:293 → 322
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:1 → 106
      MAP2_projctn; MAP2/Tau projection domain

    49. NM_001375554.1 → NP_001362483.1  microtubule-associated protein 2 isoform 29

      Status: REVIEWED

      Description
      Transcript Variant: This variant (58), as well as variant 57, encodes isoform 29.
      Source sequence(s)
      AC006385, AC079833
      Conserved Domains (3) summary
      PTZ00449
      Location:49 → 289
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:293 → 322
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:1 → 106
      MAP2_projctn; MAP2/Tau projection domain

    50. NM_001375555.1 → NP_001362484.1  microtubule-associated protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1290 → 1530
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1534 → 1563
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:219 → 1347
      MAP2_projctn; MAP2/Tau projection domain

    51. NM_001375556.1 → NP_001362485.1  microtubule-associated protein 2 isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (34), as well as variants 12, 35, and 36, encodes isoform 16.
      Source sequence(s)
      AC006385, AC079833
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1290 → 1530
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1534 → 1563
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:219 → 1347
      MAP2_projctn; MAP2/Tau projection domain

    52. NM_001375557.1 → NP_001362486.1  microtubule-associated protein 2 isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (35), as well as variants 12, 34, and 36, encodes isoform 16.
      Source sequence(s)
      AC006385, AC079833
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1290 → 1530
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1534 → 1563
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:219 → 1347
      MAP2_projctn; MAP2/Tau projection domain

    53. NM_001375558.1 → NP_001362487.1  microtubule-associated protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1290 → 1529
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1533 → 1562
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:219 → 1346
      MAP2_projctn; MAP2/Tau projection domain

    54. NM_001375559.1 → NP_001362488.1  microtubule-associated protein 2 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833
      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1249 → 1529
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1533 → 1562
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:219 → 1347
      MAP2_projctn; MAP2/Tau projection domain

    55. NM_001375583.1 → NP_001362512.1  microtubule-associated protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (60), as well as variants 2, 8, and 11, encodes isoform 2.
      Source sequence(s)
      AC006385, AC019106, AC079833, AC108072
      Consensus CDS
      CCDS2385.1
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Conserved Domains (1) summary
      pfam00418
      Location:367 → 398
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    56. NM_002374.4 → NP_002365.3  microtubule-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_002365.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) includes three alternate in-frame exons, compared to variant 2, resulting in the longest isoform (1).
      Source sequence(s)
      AC006385, AC079833, AC108072
      Consensus CDS
      CCDS2384.1
      UniProtKB/Swiss-Prot
      P11137, Q17S04, Q8IUX2, Q99975, Q99976
      UniProtKB/TrEMBL
      A0A669KB77
      Related
      ENSP00000353508.4, ENST00000360351.8
      Conserved Domains (3) summary
      PTZ00449
      Location:1448 → 1688
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1692 → 1721
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain

    57. NM_031845.3 → NP_114033.2  microtubule-associated protein 2 isoform 2

      See identical proteins and their annotated locations for NP_114033.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the shortest transcript and encodes the shortest isoform (2). Variants 2, 8, 11, and 60 all encode the same isoform (2).
      Source sequence(s)
      AC006385, AC079833, AC108072
      Consensus CDS
      CCDS2385.1
      UniProtKB/TrEMBL
      A8K5Y1, Q59FX9
      Related
      ENSP00000355290.4, ENST00000361559.8
      Conserved Domains (1) summary
      pfam00418
      Location:367 → 398
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    58. NM_031847.3 → NP_114035.2  microtubule-associated protein 2 isoform 4

      See identical proteins and their annotated locations for NP_114035.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate in-frame exon, compared to variant 2, resulting in a longer protein (isoform 4), compared to isoform 2.
      Source sequence(s)
      AC006385, AC079833, AC108072
      UniProtKB/TrEMBL
      Q59FX9
      Conserved Domains (2) summary
      PHA03247
      Location:176 → 306
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:336 → 365
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    RNA

    1. NR_164694.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833

    2. NR_164695.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833

    3. NR_164696.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833

    4. NR_164697.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833

    5. NR_164698.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833

    6. NR_164699.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006385, AC079833

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      209424047..209734112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452896.2 → XP_024308664.1  microtubule-associated protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A024R3Z1, A0A024R431, A0A669KB77
      Related
      ENSP00000515868.1, ENST00000704357.1
      Conserved Domains (3) summary
      pfam00418
      Location:1692 → 1721
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain
      cl25751
      Location:1448 → 1688
      DUF4045; Domain of unknown function (DUF4045)

    2. XM_047444387.1 → XP_047300343.1  microtubule-associated protein 2 isoform X5

    3. XM_047444388.1 → XP_047300344.1  microtubule-associated protein 2 isoform X7

    4. XM_024452894.2 → XP_024308662.1  microtubule-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      pfam00418
      Location:1745 → 1774
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1501
      MAP2_projctn; MAP2/Tau projection domain
      cl25751
      Location:1527 → 1741
      DUF4045; Domain of unknown function (DUF4045)

    5. XM_024452897.2 → XP_024308665.1  microtubule-associated protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      pfam00418
      Location:1688 → 1717
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1501
      MAP2_projctn; MAP2/Tau projection domain
      cl25751
      Location:1444 → 1684
      DUF4045; Domain of unknown function (DUF4045)

    6. XM_017004116.3 → XP_016859605.1  microtubule-associated protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A669KB77

    7. XM_047444393.1 → XP_047300349.1  microtubule-associated protein 2 isoform X17

      Conserved Domains (1) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    8. XM_011511195.3 → XP_011509497.1  microtubule-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (2) summary
      pfam00418
      Location:1748 → 1777
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:376 → 1504
      MAP2_projctn; MAP2/Tau projection domain

    9. XM_024452902.2 → XP_024308670.1  microtubule-associated protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1447 → 1687
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1691 → 1720
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:376 → 1504
      MAP2_projctn; MAP2/Tau projection domain

    10. XM_024452895.2 → XP_024308663.1  microtubule-associated protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      pfam00418
      Location:1744 → 1773
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:372 → 1500
      MAP2_projctn; MAP2/Tau projection domain
      cl25751
      Location:1526 → 1740
      DUF4045; Domain of unknown function (DUF4045)

    11. XM_024452899.2 → XP_024308667.1  microtubule-associated protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      pfam00418
      Location:1687 → 1716
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:372 → 1500
      MAP2_projctn; MAP2/Tau projection domain
      cl25751
      Location:1443 → 1683
      DUF4045; Domain of unknown function (DUF4045)

    12. XM_024452907.2 → XP_024308675.1  microtubule-associated protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1443 → 1683
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1687 → 1716
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:372 → 1500
      MAP2_projctn; MAP2/Tau projection domain

    13. XM_017004128.3 → XP_016859617.1  microtubule-associated protein 2 isoform X13

      UniProtKB/TrEMBL
      A0A669KB77

    14. XM_017004129.3 → XP_016859618.1  microtubule-associated protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A669KB77

    15. XM_024452893.2 → XP_024308661.1  microtubule-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1531 → 1745
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1749 → 1778
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain

    16. XM_047444386.1 → XP_047300342.1  microtubule-associated protein 2 isoform X3

    17. XM_017004113.3 → XP_016859602.1  microtubule-associated protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      pfam00418
      Location:1744 → 1773
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:372 → 1500
      MAP2_projctn; MAP2/Tau projection domain
      cl25751
      Location:1526 → 1740
      DUF4045; Domain of unknown function (DUF4045)

    18. XM_017004112.3 → XP_016859601.1  microtubule-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      PTZ00449
      Location:1531 → 1745
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:1749 → 1778
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain

    19. XM_017004114.3 → XP_016859603.1  microtubule-associated protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A024R3Z1, A0A024R431, A0A669KB77
      Conserved Domains (3) summary
      pfam00418
      Location:1692 → 1721
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1505
      MAP2_projctn; MAP2/Tau projection domain
      cl25751
      Location:1448 → 1688
      DUF4045; Domain of unknown function (DUF4045)

    20. XM_047444389.1 → XP_047300345.1  microtubule-associated protein 2 isoform X7

    21. XM_011511196.4 → XP_011509498.1  microtubule-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      pfam00418
      Location:1745 → 1774
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1501
      MAP2_projctn; MAP2/Tau projection domain
      cl25751
      Location:1527 → 1741
      DUF4045; Domain of unknown function (DUF4045)

    22. XM_047444390.1 → XP_047300346.1  microtubule-associated protein 2 isoform X15

    23. XM_047444392.1 → XP_047300348.1  microtubule-associated protein 2 isoform X16

      Conserved Domains (2) summary
      PTZ00449
      Location:175 → 389
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam00418
      Location:393 → 422
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    24. XM_011511197.4 → XP_011509499.1  microtubule-associated protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A669KB77
      Conserved Domains (3) summary
      pfam00418
      Location:1744 → 1773
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:372 → 1500
      MAP2_projctn; MAP2/Tau projection domain
      cl25751
      Location:1526 → 1740
      DUF4045; Domain of unknown function (DUF4045)

    25. XM_047444391.1 → XP_047300347.1  microtubule-associated protein 2 isoform X15

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      209904237..210214222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342093.1 → XP_054198068.1  microtubule-associated protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A024R3Z1, A0A024R431

    2. XM_054342092.1 → XP_054198067.1  microtubule-associated protein 2 isoform X5

    3. XM_054342095.1 → XP_054198070.1  microtubule-associated protein 2 isoform X7

    4. XM_054342086.1 → XP_054198061.1  microtubule-associated protein 2 isoform X3

    5. XM_054342097.1 → XP_054198072.1  microtubule-associated protein 2 isoform X8

    6. XM_054342099.1 → XP_054198074.1  microtubule-associated protein 2 isoform X10

    7. XM_054342107.1 → XP_054198082.1  microtubule-associated protein 2 isoform X17

    8. XM_054342085.1 → XP_054198060.1  microtubule-associated protein 2 isoform X2

    9. XM_054342100.1 → XP_054198075.1  microtubule-associated protein 2 isoform X11

    10. XM_054342090.1 → XP_054198065.1  microtubule-associated protein 2 isoform X4

    11. XM_054342098.1 → XP_054198073.1  microtubule-associated protein 2 isoform X9

    12. XM_054342101.1 → XP_054198076.1  microtubule-associated protein 2 isoform X12

    13. XM_054342102.1 → XP_054198077.1  microtubule-associated protein 2 isoform X13

    14. XM_054342103.1 → XP_054198078.1  microtubule-associated protein 2 isoform X14

    15. XM_054342084.1 → XP_054198059.1  microtubule-associated protein 2 isoform X1

    16. XM_054342088.1 → XP_054198063.1  microtubule-associated protein 2 isoform X3

    17. XM_054342089.1 → XP_054198064.1  microtubule-associated protein 2 isoform X4

    18. XM_054342083.1 → XP_054198058.1  microtubule-associated protein 2 isoform X1

    19. XM_054342094.1 → XP_054198069.1  microtubule-associated protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A024R3Z1, A0A024R431

    20. XM_054342096.1 → XP_054198071.1  microtubule-associated protein 2 isoform X7

    21. XM_054342087.1 → XP_054198062.1  microtubule-associated protein 2 isoform X3

    22. XM_054342104.1 → XP_054198079.1  microtubule-associated protein 2 isoform X15

    23. XM_054342106.1 → XP_054198081.1  microtubule-associated protein 2 isoform X16

    24. XM_054342091.1 → XP_054198066.1  microtubule-associated protein 2 isoform X4

    25. XM_054342105.1 → XP_054198080.1  microtubule-associated protein 2 isoform X15

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031846.2: Suppressed sequence

      Description
      NM_031846.2: This RefSeq was permanently suppressed because currently there is insufficient support for the exon combination represented in this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11137.4 GenPept UniProtKB/Swiss-Prot:P11137

    Gene LinkOut

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