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Conserved domains on  [gi|1370477705|ref|XP_024308667|]
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microtubule-associated protein 2 isoform X9 [Homo sapiens]

Protein Classification

MAP2_projctn and Tubulin-binding domain-containing protein( domain architecture ID 12090540)

MAP2_projctn and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MAP2_projctn pfam08377
MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which ...
372-1500 0e+00

MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.


:

Pssm-ID: 429957 [Multi-domain]  Cd Length: 1134  Bit Score: 1929.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  372 DKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAV 451
Cdd:pfam08377    1 DKMADMPMSEAITQSMDVHKPTVEESVGQRGVGEEKDIPRQENDLRKETFTPSGQEPALTESEPYRKLEEKSSVSVEESV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  452 PKESKPPKPADEEIGIIQTSTEHTFS--EQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQ 529
Cdd:pfam08377   81 PKESKLLKGLDEEKGTIQTSTEHTFSkeEQKSKEATVDQLKQDSFPGSLEQAVTDAAMLSKTLEKMPVEPSARSEKAEIQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  530 ELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHK 609
Cdd:pfam08377  161 SLFEEREIDKDKAEGAGAATPAEVEMPFYEDKSGMSKYFETSALKEEATKSLQQGSDYYELSDSRESAYESYDTVSPMFK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  610 NGDKEFQTgKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSA 689
Cdd:pfam08377  241 DGDKESLA-KASQPSPPACEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSA 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  690 IEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEE-QIEKVK 768
Cdd:pfam08377  320 IEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPTESKEEEeEVEEAK 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  769 ATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDE 848
Cdd:pfam08377  400 ATGVESTQVESSSESPFLAKEYYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSEVVVHDSGTGLPPVGDK 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  849 NHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDK 928
Cdd:pfam08377  480 NHVAVKDDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGLFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFGGEK 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  929 EASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSE 1008
Cdd:pfam08377  560 EASPPVSGDKSGLSREFDQDRKANDKLDTVLEKSEEHMDSKEHAKLGEEVGDKVEMFGLGVTYEQASAKVLTQSQDTSPE 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1009 KAEKGLSSVPEIAEVEPSKKVEQGLDFAV----QGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEAD 1084
Cdd:pfam08377  640 KAEKGLSSVPEVAEVEPLPKAEQGLDPAAkadpQQPLDVKVSDFGQMASGQDGDSQGPAELKFEAQQEGTGSSRAPQEVD 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1085 AFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKL 1164
Cdd:pfam08377  720 LFMGAESGHGKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKPDEGKKETSPEPSLIQDEVAVKL 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1165 SVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLL 1244
Cdd:pfam08377  800 SVEIPCPPPVSEADAVLDEGADVQMEFIQQPKEESQETPDISITPSDVLEPQPETLVSEPAEASAEEEEIEARGEYDKLL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1245 FRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDeE 1324
Cdd:pfam08377  880 FRSDTLQITDLSVPGDREEFVETCPGEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALDQPEVERRPSPHD-E 958
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1325 EFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPK 1404
Cdd:pfam08377  959 EPEVEEAAEAQAEPKDGSPEAPASPEKEEVGLSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPK 1038
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1405 EEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKP 1484
Cdd:pfam08377 1039 EEKAEKEARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKP 1118
                         1130
                   ....*....|....*.
gi 1370477705 1485 AIKYTRPTHLSCVKRK 1500
Cdd:pfam08377 1119 AIKYTRPTHLSCVKRK 1134
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1687-1716 9.69e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 66.67  E-value: 9.69e-14
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370477705 1687 VRILNKKIDFSKVQSRCGSKDNIKHSAGGG 1716
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1718-1747 4.03e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 4.03e-12
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370477705 1718 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 1747
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1749-1779 1.25e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 60.50  E-value: 1.25e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1370477705 1749 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 1779
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1656-1685 2.09e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.56  E-value: 2.09e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370477705 1656 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 1685
Cdd:pfam00418    2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
1443-1683 1.34e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.91  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1443 KEPSTVSRDEVRRKK-AVYKKAELAKKT-EVQAHSPSRKFIL--KPAIKyTRPTHLSCVKRKTTAAGGESALAPSVFKQA 1518
Cdd:PTZ00449   534 HEDSKESDEPKEGGKpGETKEGEVGKKPgPAKEHKPSKIPTLskKPEFP-KDPKHPKDPEEPKKPKRPRSAQRPTRPKSP 612
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1519 KDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRR 1579
Cdd:PTZ00449   613 KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTT 692
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1580 AGKSGTSTPTTPGSTAITPGTPPSYSSRTPgtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLI 1658
Cdd:PTZ00449   693 VVLDESFESILKETLPETPGTPFTTPRPLP--PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPA 765
                          250       260       270
                   ....*....|....*....|....*....|..
gi 1370477705 1659 NQPLPDL-------KNVKSKIGSTDNIKYQPK 1683
Cdd:PTZ00449   766 DTPLPDIlaeefkeEDIHAETGEPDEAMKRPD 797
 
Name Accession Description Interval E-value
MAP2_projctn pfam08377
MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which ...
372-1500 0e+00

MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.


Pssm-ID: 429957 [Multi-domain]  Cd Length: 1134  Bit Score: 1929.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  372 DKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAV 451
Cdd:pfam08377    1 DKMADMPMSEAITQSMDVHKPTVEESVGQRGVGEEKDIPRQENDLRKETFTPSGQEPALTESEPYRKLEEKSSVSVEESV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  452 PKESKPPKPADEEIGIIQTSTEHTFS--EQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQ 529
Cdd:pfam08377   81 PKESKLLKGLDEEKGTIQTSTEHTFSkeEQKSKEATVDQLKQDSFPGSLEQAVTDAAMLSKTLEKMPVEPSARSEKAEIQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  530 ELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHK 609
Cdd:pfam08377  161 SLFEEREIDKDKAEGAGAATPAEVEMPFYEDKSGMSKYFETSALKEEATKSLQQGSDYYELSDSRESAYESYDTVSPMFK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  610 NGDKEFQTgKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSA 689
Cdd:pfam08377  241 DGDKESLA-KASQPSPPACEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSA 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  690 IEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEE-QIEKVK 768
Cdd:pfam08377  320 IEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPTESKEEEeEVEEAK 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  769 ATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDE 848
Cdd:pfam08377  400 ATGVESTQVESSSESPFLAKEYYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSEVVVHDSGTGLPPVGDK 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  849 NHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDK 928
Cdd:pfam08377  480 NHVAVKDDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGLFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFGGEK 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  929 EASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSE 1008
Cdd:pfam08377  560 EASPPVSGDKSGLSREFDQDRKANDKLDTVLEKSEEHMDSKEHAKLGEEVGDKVEMFGLGVTYEQASAKVLTQSQDTSPE 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1009 KAEKGLSSVPEIAEVEPSKKVEQGLDFAV----QGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEAD 1084
Cdd:pfam08377  640 KAEKGLSSVPEVAEVEPLPKAEQGLDPAAkadpQQPLDVKVSDFGQMASGQDGDSQGPAELKFEAQQEGTGSSRAPQEVD 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1085 AFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKL 1164
Cdd:pfam08377  720 LFMGAESGHGKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKPDEGKKETSPEPSLIQDEVAVKL 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1165 SVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLL 1244
Cdd:pfam08377  800 SVEIPCPPPVSEADAVLDEGADVQMEFIQQPKEESQETPDISITPSDVLEPQPETLVSEPAEASAEEEEIEARGEYDKLL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1245 FRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDeE 1324
Cdd:pfam08377  880 FRSDTLQITDLSVPGDREEFVETCPGEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALDQPEVERRPSPHD-E 958
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1325 EFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPK 1404
Cdd:pfam08377  959 EPEVEEAAEAQAEPKDGSPEAPASPEKEEVGLSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPK 1038
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1405 EEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKP 1484
Cdd:pfam08377 1039 EEKAEKEARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKP 1118
                         1130
                   ....*....|....*.
gi 1370477705 1485 AIKYTRPTHLSCVKRK 1500
Cdd:pfam08377 1119 AIKYTRPTHLSCVKRK 1134
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1687-1716 9.69e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 66.67  E-value: 9.69e-14
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370477705 1687 VRILNKKIDFSKVQSRCGSKDNIKHSAGGG 1716
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1718-1747 4.03e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 4.03e-12
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370477705 1718 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 1747
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1749-1779 1.25e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 60.50  E-value: 1.25e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1370477705 1749 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 1779
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1656-1685 2.09e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.56  E-value: 2.09e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370477705 1656 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 1685
Cdd:pfam00418    2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
1443-1683 1.34e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.91  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1443 KEPSTVSRDEVRRKK-AVYKKAELAKKT-EVQAHSPSRKFIL--KPAIKyTRPTHLSCVKRKTTAAGGESALAPSVFKQA 1518
Cdd:PTZ00449   534 HEDSKESDEPKEGGKpGETKEGEVGKKPgPAKEHKPSKIPTLskKPEFP-KDPKHPKDPEEPKKPKRPRSAQRPTRPKSP 612
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1519 KDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRR 1579
Cdd:PTZ00449   613 KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTT 692
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1580 AGKSGTSTPTTPGSTAITPGTPPSYSSRTPgtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLI 1658
Cdd:PTZ00449   693 VVLDESFESILKETLPETPGTPFTTPRPLP--PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPA 765
                          250       260       270
                   ....*....|....*....|....*....|..
gi 1370477705 1659 NQPLPDL-------KNVKSKIGSTDNIKYQPK 1683
Cdd:PTZ00449   766 DTPLPDIlaeefkeEDIHAETGEPDEAMKRPD 797
 
Name Accession Description Interval E-value
MAP2_projctn pfam08377
MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which ...
372-1500 0e+00

MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.


Pssm-ID: 429957 [Multi-domain]  Cd Length: 1134  Bit Score: 1929.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  372 DKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAV 451
Cdd:pfam08377    1 DKMADMPMSEAITQSMDVHKPTVEESVGQRGVGEEKDIPRQENDLRKETFTPSGQEPALTESEPYRKLEEKSSVSVEESV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  452 PKESKPPKPADEEIGIIQTSTEHTFS--EQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQ 529
Cdd:pfam08377   81 PKESKLLKGLDEEKGTIQTSTEHTFSkeEQKSKEATVDQLKQDSFPGSLEQAVTDAAMLSKTLEKMPVEPSARSEKAEIQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  530 ELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHK 609
Cdd:pfam08377  161 SLFEEREIDKDKAEGAGAATPAEVEMPFYEDKSGMSKYFETSALKEEATKSLQQGSDYYELSDSRESAYESYDTVSPMFK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  610 NGDKEFQTgKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSA 689
Cdd:pfam08377  241 DGDKESLA-KASQPSPPACEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSA 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  690 IEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEE-QIEKVK 768
Cdd:pfam08377  320 IEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPTESKEEEeEVEEAK 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  769 ATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDE 848
Cdd:pfam08377  400 ATGVESTQVESSSESPFLAKEYYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSEVVVHDSGTGLPPVGDK 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  849 NHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDK 928
Cdd:pfam08377  480 NHVAVKDDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGLFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFGGEK 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705  929 EASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSE 1008
Cdd:pfam08377  560 EASPPVSGDKSGLSREFDQDRKANDKLDTVLEKSEEHMDSKEHAKLGEEVGDKVEMFGLGVTYEQASAKVLTQSQDTSPE 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1009 KAEKGLSSVPEIAEVEPSKKVEQGLDFAV----QGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEAD 1084
Cdd:pfam08377  640 KAEKGLSSVPEVAEVEPLPKAEQGLDPAAkadpQQPLDVKVSDFGQMASGQDGDSQGPAELKFEAQQEGTGSSRAPQEVD 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1085 AFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKL 1164
Cdd:pfam08377  720 LFMGAESGHGKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKPDEGKKETSPEPSLIQDEVAVKL 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1165 SVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLL 1244
Cdd:pfam08377  800 SVEIPCPPPVSEADAVLDEGADVQMEFIQQPKEESQETPDISITPSDVLEPQPETLVSEPAEASAEEEEIEARGEYDKLL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1245 FRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDeE 1324
Cdd:pfam08377  880 FRSDTLQITDLSVPGDREEFVETCPGEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALDQPEVERRPSPHD-E 958
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1325 EFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPK 1404
Cdd:pfam08377  959 EPEVEEAAEAQAEPKDGSPEAPASPEKEEVGLSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPK 1038
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1405 EEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKP 1484
Cdd:pfam08377 1039 EEKAEKEARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKP 1118
                         1130
                   ....*....|....*.
gi 1370477705 1485 AIKYTRPTHLSCVKRK 1500
Cdd:pfam08377 1119 AIKYTRPTHLSCVKRK 1134
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1687-1716 9.69e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 66.67  E-value: 9.69e-14
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370477705 1687 VRILNKKIDFSKVQSRCGSKDNIKHSAGGG 1716
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1718-1747 4.03e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 4.03e-12
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370477705 1718 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 1747
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1749-1779 1.25e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 60.50  E-value: 1.25e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1370477705 1749 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 1779
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
1656-1685 2.09e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.56  E-value: 2.09e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370477705 1656 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 1685
Cdd:pfam00418    2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
1443-1683 1.34e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.91  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1443 KEPSTVSRDEVRRKK-AVYKKAELAKKT-EVQAHSPSRKFIL--KPAIKyTRPTHLSCVKRKTTAAGGESALAPSVFKQA 1518
Cdd:PTZ00449   534 HEDSKESDEPKEGGKpGETKEGEVGKKPgPAKEHKPSKIPTLskKPEFP-KDPKHPKDPEEPKKPKRPRSAQRPTRPKSP 612
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1519 KDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRR 1579
Cdd:PTZ00449   613 KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTT 692
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370477705 1580 AGKSGTSTPTTPGSTAITPGTPPSYSSRTPgtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLI 1658
Cdd:PTZ00449   693 VVLDESFESILKETLPETPGTPFTTPRPLP--PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPA 765
                          250       260       270
                   ....*....|....*....|....*....|..
gi 1370477705 1659 NQPLPDL-------KNVKSKIGSTDNIKYQPK 1683
Cdd:PTZ00449   766 DTPLPDIlaeefkeEDIHAETGEPDEAMKRPD 797
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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