U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from OMIM

    • Showing Current items.

    ACOT2 acyl-CoA thioesterase 2 [ Homo sapiens (human) ]

    Gene ID: 10965, updated on 28-Oct-2024

    Summary

    Official Symbol
    ACOT2provided by HGNC
    Official Full Name
    acyl-CoA thioesterase 2provided by HGNC
    Primary source
    HGNC:HGNC:18431
    See related
    Ensembl:ENSG00000119673 MIM:609972; AllianceGenome:HGNC:18431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTE1; PTE2; CTE1A; PTE2A; CTE-IA; ZAP128
    Summary
    This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in fat (RPKM 57.3), liver (RPKM 39.8) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ACOT2 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73567620..73575658)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (67775130..67783167)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74034324..74042362)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 4 Neighboring gene acyl-CoA thioesterase 1 Neighboring gene uncharacterized LOC124903344 Neighboring gene 5',3'-nucleotidase, cytosolic pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr14:74020474-74020986 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74033223-74033740 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:74034134-74035333 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8702 Neighboring gene 5',3'-nucleotidase, cytosolic pseudogene 1 Neighboring gene tRNA-Lys (TTT) 14-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:74058811-74059310 Neighboring gene acyl-CoA thioesterase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    acyl-coenzyme A thioesterase 2, mitochondrial
    Names
    acyl-coenzyme A thioester hydrolase 2a
    long-chain acyl-CoA thioesterase 2
    mitochondrial acyl-CoA thioesterase 1
    peroxisomal long-chain acyl-coA thioesterase 2
    NP_001351106.1
    NP_001351107.1
    NP_006812.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364177.1NP_001351106.1  acyl-coenzyme A thioesterase 2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005225
      UniProtKB/TrEMBL
      B3KSA0
      Conserved Domains (1) summary
      pfam08840
      Location:69277
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    2. NM_001364178.1NP_001351107.1  acyl-coenzyme A thioesterase 2, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005225
      Conserved Domains (2) summary
      pfam04775
      Location:78198
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      cl21494
      Location:266282
      Abhydrolase; alpha/beta hydrolases
    3. NM_006821.6NP_006812.3  acyl-coenzyme A thioesterase 2, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_006812.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AC005225
      Consensus CDS
      CCDS9816.1
      UniProtKB/Swiss-Prot
      P49753, Q3I5F8, Q53EK4, Q9NUX4
      UniProtKB/TrEMBL
      A0A087WT95
      Related
      ENSP00000238651.5, ENST00000238651.10
      Conserved Domains (3) summary
      pfam04775
      Location:79198
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:266474
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      cl21494
      Location:207319
      Abhydrolase; alpha/beta hydrolases

    RNA

    1. NR_046028.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005225, AI537078, AK093131
      Related
      ENST00000538782.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      73567620..73575658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      67775130..67783167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)