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Conserved domains on  [gi|1398331565|ref|NP_001351107|]
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acyl-coenzyme A thioesterase 2, mitochondrial isoform 3 [Homo sapiens]

Protein Classification

acyl-CoA thioesterase/bile acid-CoA:amino acid N-acyltransferase family protein( domain architecture ID 10521448)

acyl-CoA thioesterase/bile acid-CoA:amino acid N-acyltransferase (BAAT) family protein may catalyze the hydrolysis of acyl-CoA or catalyze the amidation of bile acids with the amino acids taurine and glycine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bile_Hydr_Trans pfam04775
Acyl-CoA thioester hydrolase/BAAT N-terminal region; This family consists of the amino termini ...
 78-202 1.94e-54

Acyl-CoA thioester hydrolase/BAAT N-terminal region; This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT). This region is not thought to contain the active site of either enzyme. Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have distinct functions in lipid metabolism. For example, in peroxisomes, the hydrolase acts on bile-CoA esters.


:

Pssm-ID: 461422  Cd Length: 127  Bit Score: 173.19  E-value: 1.94e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331565  78 DEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPL-VRLV 156
Cdd:pfam04775   1 DEPVHIRVSGLPPGQPVTLRALLTDEKGGLFESYAVYRADENGEVDLSRDAPLGGSYTGVDPMGLFWSMKPEPGFrPRLY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1398331565 157 KRDV-RTPLAVELEVLDGHDPdPGRLLCQTRHERYFLPPGVRREPVR 202
Cdd:pfam04775  81 KRDVlPTPFVVTLSVYDGSEE-SGKPLASVTVERWYMAPGVRRIEVR 126
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
205-282 1.10e-05

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


:

Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 45.78  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331565 205 RVRGTLFLPPEPGPFPGIVDMFGTGGGLLE---YRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNYLLSHP 281
Cdd:COG1506     9 TLPGWLYLPADGKKYPVVVYVHGGPGSRDDsflPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAIDYLAARP 88


                  .
gi 1398331565 282 E 282
Cdd:COG1506    89 Y 89
 
Name Accession Description Interval E-value
Bile_Hydr_Trans pfam04775
Acyl-CoA thioester hydrolase/BAAT N-terminal region; This family consists of the amino termini ...
 78-202 1.94e-54

Acyl-CoA thioester hydrolase/BAAT N-terminal region; This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT). This region is not thought to contain the active site of either enzyme. Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have distinct functions in lipid metabolism. For example, in peroxisomes, the hydrolase acts on bile-CoA esters.


Pssm-ID: 461422  Cd Length: 127  Bit Score: 173.19  E-value: 1.94e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331565  78 DEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPL-VRLV 156
Cdd:pfam04775   1 DEPVHIRVSGLPPGQPVTLRALLTDEKGGLFESYAVYRADENGEVDLSRDAPLGGSYTGVDPMGLFWSMKPEPGFrPRLY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1398331565 157 KRDV-RTPLAVELEVLDGHDPdPGRLLCQTRHERYFLPPGVRREPVR 202
Cdd:pfam04775  81 KRDVlPTPFVVTLSVYDGSEE-SGKPLASVTVERWYMAPGVRRIEVR 126
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
205-282 1.10e-05

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 45.78  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331565 205 RVRGTLFLPPEPGPFPGIVDMFGTGGGLLE---YRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNYLLSHP 281
Cdd:COG1506     9 TLPGWLYLPADGKKYPVVVYVHGGPGSRDDsflPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAIDYLAARP 88


                  .
gi 1398331565 282 E 282
Cdd:COG1506    89 Y 89
BAAT_C pfam08840
BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C ...
 265-282 7.49e-04

BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).


Pssm-ID: 430252 [Multi-domain]  Cd Length: 211  Bit Score: 39.96  E-value: 7.49e-04
                          10
                  ....*....|....*...
gi 1398331565 265 LHLEYFEEAMNYLLSHPE 282
Cdd:pfam08840   1 VDLEYFEEAINYLLRHPK 18
 
Name Accession Description Interval E-value
Bile_Hydr_Trans pfam04775
Acyl-CoA thioester hydrolase/BAAT N-terminal region; This family consists of the amino termini ...
 78-202 1.94e-54

Acyl-CoA thioester hydrolase/BAAT N-terminal region; This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT). This region is not thought to contain the active site of either enzyme. Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have distinct functions in lipid metabolism. For example, in peroxisomes, the hydrolase acts on bile-CoA esters.


Pssm-ID: 461422  Cd Length: 127  Bit Score: 173.19  E-value: 1.94e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331565  78 DEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPL-VRLV 156
Cdd:pfam04775   1 DEPVHIRVSGLPPGQPVTLRALLTDEKGGLFESYAVYRADENGEVDLSRDAPLGGSYTGVDPMGLFWSMKPEPGFrPRLY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1398331565 157 KRDV-RTPLAVELEVLDGHDPdPGRLLCQTRHERYFLPPGVRREPVR 202
Cdd:pfam04775  81 KRDVlPTPFVVTLSVYDGSEE-SGKPLASVTVERWYMAPGVRRIEVR 126
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
205-282 1.10e-05

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 45.78  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331565 205 RVRGTLFLPPEPGPFPGIVDMFGTGGGLLE---YRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNYLLSHP 281
Cdd:COG1506     9 TLPGWLYLPADGKKYPVVVYVHGGPGSRDDsflPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAIDYLAARP 88


                  .
gi 1398331565 282 E 282
Cdd:COG1506    89 Y 89
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
204-282 1.89e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 41.88  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331565 204 GRVRGTLFLPPEPGPFPGIV---DMFGTGGGlLEYRASLLAGKGFAVMALAYYNYEDLPKTMET-----------LHLEY 269
Cdd:COG0412    14 VTLPGYLARPAGGGPRPGVVvlhEIFGLNPH-IRDVARRLAAAGYVVLAPDLYGRGGPGDDPDEaralmgaldpeLLAAD 92

                          90
                  ....*....|...
gi 1398331565 270 FEEAMNYLLSHPE 282
Cdd:COG0412    93 LRAALDWLKAQPE 105
BAAT_C pfam08840
BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C ...
 265-282 7.49e-04

BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).


Pssm-ID: 430252 [Multi-domain]  Cd Length: 211  Bit Score: 39.96  E-value: 7.49e-04
                          10
                  ....*....|....*...
gi 1398331565 265 LHLEYFEEAMNYLLSHPE 282
Cdd:pfam08840   1 VDLEYFEEAINYLLRHPK 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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