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    MYO5C myosin VC [ Homo sapiens (human) ]

    Gene ID: 55930, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MYO5Cprovided by HGNC
    Official Full Name
    myosin VCprovided by HGNC
    Primary source
    HGNC:HGNC:7604
    See related
    Ensembl:ENSG00000128833 MIM:610022; AllianceGenome:HGNC:7604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thyroid (RPKM 12.9), stomach (RPKM 10.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYO5C in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (52192322..52295804, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (50000957..50104091, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52484519..52588001, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9423 Neighboring gene BCL2 like 10 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39709 Neighboring gene G protein subunit beta 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52472339-52472840 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52483687-52484186 Neighboring gene competing endogenous lncRNA 1 for miR-4707-5p and miR-4767 Neighboring gene uncharacterized LOC105370820 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:52521219-52521393 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:52549514-52550090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:52552397-52552972 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:52578302-52579058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9425 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6446 Neighboring gene uncharacterized LOC105370819 Neighboring gene microRNA 1266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9426 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:52630438-52631014 Neighboring gene myosin VA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9429 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:52684277-52684953 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:52751737-52752632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:52757960-52758715 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:52769819-52770320 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:52770321-52770820 Neighboring gene negCOR silencer S8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6447 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52838153-52838654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52860078-52860826 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52860827-52861573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9432 Neighboring gene cAMP regulated phosphoprotein 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Force-producing ADP state of myosin bound to actin. Wulf SF, et al. Proc Natl Acad Sci U S A, 2016 Mar 29. PMID 26976594, Free PMC Article
    2. Human myosin Vc is a low duty ratio, nonprocessive molecular motor. Takagi Y, et al. J Biol Chem, 2008 Mar 28. PMID 18201966
    3. Human myosin Vc is a low duty ratio nonprocessive motor. Watanabe S, et al. J Biol Chem, 2008 Apr 18. PMID 18079121, Free PMC Article
    4. Myosin Vc Is Specialized for Transport on a Secretory Superhighway. Sladewski TE, et al. Curr Biol, 2016 Aug 22. PMID 27498562, Free PMC Article
    5. Identification of the Isoform-specific Interactions between the Tail and the Head of Class V Myosin. Yao LL, et al. J Biol Chem, 2016 Apr 8. PMID 26912658, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spire1 and Myosin Vc promote Ca(2+)-evoked externalization of von Willebrand factor in endothelial cells.
      Title: Spire1 and Myosin Vc promote Ca(2+)-evoked externalization of von Willebrand factor in endothelial cells.
    2. Pendred Syndrome, or Not Pendred Syndrome? That Is the Question.
      Title: Pendred Syndrome, or Not Pendred Syndrome? That Is the Question.
    3. Unveiling the interaction between the molecular motor Myosin Vc and the small GTPase Rab3A.
      Title: Unveiling the interaction between the molecular motor Myosin Vc and the small GTPase Rab3A.
    4. MyoVc is unique in taking variable size steps, which are frequently in the backward direction. Results obtained with chimeric constructs implicate the lever arm/rod of MyoVc as being responsible for these properties. Actin bundles allow single MyoVc motors to move processively.
      Title: Myosin Vc Is Specialized for Transport on a Secretory Superhighway.
    5. The myosin V structure reveals the detailed rearrangements underlying myosin force generation as well as the basis of strain-dependent ADP release that is essential for processive myosins, such as myosin V.
      Title: Force-producing ADP state of myosin bound to actin.
    6. Myo5c-globular tail domain and Myo5a-globular tail domain are not interchangeable in terms of inhibiting the motor function.
      Title: Identification of the Isoform-specific Interactions between the Tail and the Head of Class V Myosin.
    7. Rab38 and its close homolog Rab32 bind to Myosin Vc but not to Myosin Va or Myosin Vb. Binding depends on residues in the switch II region of Rab32 and Rab38 and regions of the Myosin Vc coiled-coil tail domain.
      Title: Myosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomes.
    8. Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.
      Title: Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.
    9. the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb, and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD dimerization process
      Title: Structural insights into functional overlapping and differentiation among myosin V motors.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC74969

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle transport along actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-Vc
    Names
    myosin 5C
    myosin-Vc

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018728.4 → NP_061198.2  unconventional myosin-Vc

      See identical proteins and their annotated locations for NP_061198.2

      Status: VALIDATED

      Source sequence(s)
      AC010674
      Consensus CDS
      CCDS42036.1
      UniProtKB/Swiss-Prot
      Q6P1W8, Q9NQX4
      Related
      ENSP00000261839.7, ENST00000261839.12
      Conserved Domains (11) summary
      smart00015
      Location:810 → 828
      IQ; Calmodulin-binding motif
      smart00242
      Location:62 → 752
      MYSc; Myosin. Large ATPases
      COG1340
      Location:890 → 1150
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd15476
      Location:1369 → 1736
      Myo5c_CBD; Cargo binding domain of myosin 5C
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam02736
      Location:12 → 48
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam09311
      Location:1020 → 1345
      Rab5-bind; Rabaptin-like protein
      cd16269
      Location:997 → 1010
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:927 → 1030
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21455
      Location:910 → 1163
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl23748
      Location:1160 → 1326
      DUF3585; Protein of unknown function (DUF3585)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      52192322..52295804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432845.1 → XP_047288801.1  unconventional myosin-Vc isoform X3

    2. XM_017022408.3 → XP_016877897.1  unconventional myosin-Vc isoform X2

    3. XM_011521781.4 → XP_011520083.1  unconventional myosin-Vc isoform X1

      Conserved Domains (10) summary
      smart00242
      Location:62 → 752
      MYSc; Myosin. Large ATPases
      COG1340
      Location:862 → 1122
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd15476
      Location:1341 → 1708
      Myo5c_CBD; Cargo binding domain of myosin 5C
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam02736
      Location:12 → 48
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam09311
      Location:992 → 1317
      Rab5-bind; Rabaptin-like protein
      cd16269
      Location:969 → 982
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:899 → 1002
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21455
      Location:882 → 1135
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl23748
      Location:1132 → 1298
      DUF3585; Protein of unknown function (DUF3585)

    4. XM_047432846.1 → XP_047288802.1  unconventional myosin-Vc isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      50000957..50104091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378430.1 → XP_054234405.1  unconventional myosin-Vc isoform X3

    2. XM_054378429.1 → XP_054234404.1  unconventional myosin-Vc isoform X2

    3. XM_054378428.1 → XP_054234403.1  unconventional myosin-Vc isoform X1

    4. XM_054378431.1 → XP_054234406.1  unconventional myosin-Vc isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NQX4.2 GenPept UniProtKB/Swiss-Prot:Q9NQX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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