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    grn grain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40962, updated on 2-Nov-2024

    Summary

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    Official Symbol
    grnprovided by FlyBase
    Official Full Name
    grainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001138
    Locus tag
    Dmel_CG9656
    See related
    AllianceGenome:FB:FBgn0001138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9656; CG9656-PA; dGATA-2; dGatac; dGATAc; Dmel\CG9656; Gata-c; Gata2; GATAc; gra; GRAIN; Grn; l(3)84Fa
    Summary
    Enables sequence-specific DNA binding activity. Involved in animal organ morphogenesis; motor neuron axon guidance; and tissue development. Predicted to be active in nucleus. Is expressed in several structures, including T neuron; embryonic/larval motor neurons; head epidermis primordium; leg disc; and segment of leg. Human ortholog(s) of this gene implicated in several diseases, including depressive disorder; hematologic cancer (multiple); hypoparathyroidism-deafness-renal disease syndrome; immunodeficiency 21; and sensorineural hearing loss. Orthologous to several human genes including GATA3 (GATA binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See grn in Genome Data Viewer
    Location:
    84F1-84F1; 3-48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8147368..8181444, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3973090..4007166, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Arginine-ACG 1-10 Neighboring gene transfer RNA:Arginine-ACG 1-9 Neighboring gene long non-coding RNA:CR43302 Neighboring gene long non-coding RNA:CR43303

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-cell RNA sequencing in Drosophila: Technologies and applications. Li H. Wiley Interdiscip Rev Dev Biol, 2021 Sep. PMID 32940008, Free PMC Article
    2. A combinatorial code of transcription factors specifies subtypes of visual motion-sensing neurons in Drosophila. Hörmann N, et al. Development, 2020 May 13. PMID 32238425, Free PMC Article
    3. Expression of a Drosophila GATA transcription factor in multiple tissues in the developing embryos. Identification of homozygous lethal mutants with P-element insertion at the promoter region. Lin WH, et al. J Biol Chem, 1995 Oct 20. PMID 7559649
    4. Two forms of type IV zinc-finger motif and their kingdom-specific distribution between the flora, fauna and fungi. Teakle GR, et al. Trends Biochem Sci, 1998 Mar. PMID 9581501
    5. How Flies See Motion. Borst A, et al. Annu Rev Neurosci, 2023 Jul 10. PMID 37428604

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dGATAe and grn expression are independent of each other; dGATAe and grn are not responsible for setting the general embryonic midgut morphology; results clarify the expression patterns and function of the GATA factor genes expressed in the embryonic midgut
      Title: GATA factor genes in the Drosophila midgut embryo.
    2. Grain is necessary for neuronal cell fate specification
      Title: Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade.
    3. Data strongly suggests that the eve-grn transcriptional code controls axon guidance, in part, by regulating the level of unc-5 expression.
      Title: A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor.
    4. An eve-->grn-->zfh1 genetic cascade is unique to one of the intersegmental motoneurons, the aCC.
      Title: Specification of Drosophila aCC motoneuron identity by a genetic cascade involving even-skipped, grain and zfh1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    grain
    Names
    CG9656-PA
    CG9656-PB
    CG9656-PC
    GATA-factor-c
    grn-PA
    grn-PB
    grn-PC
    lethal(3)84Fa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8147368..8181444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169206.3 → NP_731211.1  grain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731211.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91623, Q9VHV4
      Related
      FBpp0081304
      Conserved Domains (2) summary
      smart00401
      Location:316 → 365
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:320 → 370
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    2. NM_001144554.3 → NP_001138026.1  grain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0V4
      Conserved Domains (2) summary
      smart00401
      Location:529 → 578
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:533 → 583
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    3. NM_001275437.2 → NP_001262366.1  grain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFB6
      Conserved Domains (2) summary
      smart00401
      Location:529 → 578
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:533 → 583
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFB6 A0A0B4KFB6
    B7Z0V4 B7Z0V4
    P91623.1 P91623

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