VIM vimentin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: VIMprovided by VGNC
Official Full Name: vimentinprovided by VGNC
Primary source: VGNC:VGNC:48263
See related: Ensembl:ENSCAFG00845013892
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (19962890..19970942, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (16774615..16782665, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (18621519..18629571, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (17165331..17173380, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (18003247..18011326, complement)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of filamin A or vimentin in normal cells profoundly suppresses apical extrusion of the neighbouring transformed cells.
Title: Filamin acts as a key regulator in epithelial defence against transformed cells.
KRAP mediates InsP(3)R clustering in confluent MDCK cells and functions as an adapter, linking InsP(3)Rs to vimentin intermediate filaments.
Title: Vimentin and the K-Ras-induced actin-binding protein control inositol-(1,4,5)-trisphosphate receptor redistribution during MDCK cell differentiation.
The development of a simple and rapid immunocytochemical technique for detection of cytokeratin, vimentin, and S-100 protein is reported.
Title: A simple and rapid immunocytochemical technique for detection of cytokeratin, vimentin, and S-100 protein in veterinary diagnostic cytology.
The upregulation of vimentin expression during epithelial to mesenchymal transitions may stabilize Scrib to promote directed cell migration.
Title: Vimentin regulates scribble activity by protecting it from proteasomal degradation.
Results suggest that Cdc42GAP regulates the vimentin network through the Cdc42-PAK pathway in smooth muscle cells during 5-HT stimulation.
Title: Cdc42GAP, reactive oxygen species, and the vimentin network.
These studies suggest that vimentin filaments play an important role in mediating active force development and passive tension, which are not regulated by myosin light chain phosphorylation.
Title: Role of vimentin in smooth muscle force development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_50823-50824:1132087879:1 (e-PCR)
- UniSTS:477520

MARC_31619-31620:1062167711:1 (e-PCR)
- UniSTS:269211

Vim (e-PCR), detects polymorphism
- UniSTS:461982

VIM (e-PCR)
- UniSTS:527007

Vim (e-PCR), detects polymorphism
- UniSTS:527007

Vim (e-PCR), detects polymorphism
- UniSTS:507308

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in intermediate filament	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: vimentin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.