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Clasp2 CLIP associating protein 2 [ Mus musculus (house mouse) ]

Gene ID: 76499, updated on 2-Nov-2024

Summary

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Official Symbol: Clasp2provided by MGI
Official Full Name: CLIP associating protein 2provided by MGI
Primary source: MGI:MGI:1923749
See related: Ensembl:ENSMUSG00000033392 AllianceGenome:MGI:1923749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0627; CLASP2beta; 1500004F14Rik; 8030404L10Rik
Summary: Enables microtubule binding activity. Involved in cell migration and establishment of cell polarity. Acts upstream of or within establishment or maintenance of cell polarity; fibroblast migration; and negative regulation of microtubule depolymerization. Located in Golgi apparatus; cell leading edge; and microtubule. Is expressed in central nervous system; dorsal root ganglion; early conceptus; oocyte; and trigeminal nerve. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 23.3), cerebellum adult (RPKM 19.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

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See Clasp2 in Genome Data Viewer

Location:: 9 F3; 9 64.06 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (113567776..113748765)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (113740077..113919697)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
Title: CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs.
Title: Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs.
The novel protein SOGA1 was confirmed to colocalize with a microtubule-associated protein CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein.
Title: Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein.
data reveal that CLASP2 is an essential Reelin effector orchestrating cytoskeleton dynamics during brain development.
Title: CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development.
These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features.
Title: Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes.
A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.
Title: CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.
the functional relationship between Abl and CLASP2 is conserved and provides a means to control the CLASP2 association with the cytoskeleton.
Title: Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin.
The MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse keratinocytes.
Title: CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions.
CLASP2 is required for the proper attachment of fibroblasts, HSC-enriched cells, and platelets, indicating a general role for this protein in cell attachment.
Title: The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance.
CLASP2 directs the delivery of GLUT4 to cell cortex landing zones important for insulin action
Title: Identification of a role for CLASP2 in insulin action.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126165 (e-PCR)
- UniSTS:162876

BB249004 (e-PCR)
- UniSTS:208460

AU022707 (e-PCR)
- UniSTS:208461

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

D9Mit246 (e-PCR), detects polymorphism
- UniSTS:131814

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule organizing center organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule organizing center organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in presynaptic cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule-based process	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule-based process	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle targeting	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
is_active_in basal cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in basal cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cortical microtubule plus-end	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with kinetochore	ISO Inferred from Sequence Orthology more info
colocalizes_with kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with mitotic spindle	ISO Inferred from Sequence Orthology more info
colocalizes_with mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CLIP-associating protein 2

Names: CLASP2alpha; CLASP2gamma; CLIP-associating protein CLASP2; cytoplasmic linker-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081960.1 → NP_001075429.1 CLIP-associating protein 2 isoform b

See identical proteins and their annotated locations for NP_001075429.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform b, which has a shorter and distinct N-terminus, compared to isoform c.

Source sequence(s)

AC107803, AK164326, BC117963

Consensus CDS

CCDS40787.1

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

UniProtKB/TrEMBL

Q08EB6

Related

ENSMUSP00000130201.3, ENSMUST00000166734.10

Conserved Domains (2) summary

pfam12348
Location:100 → 311

CLASP_N; CLASP N terminal

sd00044
Location:1057 → 1079

HEAT; HEAT repeat [structural motif]
NM_001114347.1 → NP_001107819.1 CLIP-associating protein 2 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).

Source sequence(s)

AC107803, AC167246

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (2) summary

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]
NM_001286599.1 → NP_001273528.1 CLIP-associating protein 2 isoform d

See identical proteins and their annotated locations for NP_001273528.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 3' UTR, lacks a portion of the 3' coding region, and includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform d, which has a shorter and distinct C-terminus, compared to isoform c.

Source sequence(s)

AI529145, AK005146, AK034560

Consensus CDS

CCDS90675.1

UniProtKB/TrEMBL

Q8BSE7

Related

ENSMUSP00000150741.2, ENSMUST00000216817.2

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:81 → 197

CLASP_N; CLASP N terminal
NM_001286600.1 → NP_001273529.1 CLIP-associating protein 2 isoform e

See identical proteins and their annotated locations for NP_001273529.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform e, which is shorter and has a distinct N-terminus, compared to isoform c.

Source sequence(s)

AC107803, AK043551, AK148966

Consensus CDS

CCDS90676.1

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

UniProtKB/TrEMBL

Q08EB5

Related

ENSMUSP00000149670.2, ENSMUST00000214522.2

Conserved Domains (2) summary

pfam12348
Location:100 → 311

CLASP_N; CLASP N terminal

sd00044
Location:1074 → 1096

HEAT; HEAT repeat [structural motif]
NM_001286601.1 → NP_001273530.1 CLIP-associating protein 2 isoform f

See identical proteins and their annotated locations for NP_001273530.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform f, which is shorter and has a distinct N-terminus, compared to isoform c.

Source sequence(s)

AC107803, AK043551, AK164326

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

UniProtKB/TrEMBL

A2RRR3

Conserved Domains (2) summary

pfam12348
Location:2 → 113

CLASP_N; CLASP N terminal

sd00044
Location:859 → 881

HEAT; HEAT repeat [structural motif]
NM_001286602.1 → NP_001273531.1 CLIP-associating protein 2 isoform g

See identical proteins and their annotated locations for NP_001273531.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform g, which is shorter and has a distinct N-terminus, compared to isoform c.

Source sequence(s)

AC107803, AK043551, AK164326

UniProtKB/TrEMBL

B9EJA4, F7DCH5

Related

ENSMUSP00000128460.3, ENSMUST00000163895.3

Conserved Domains (2) summary

sd00044
Location:1078 → 1100

HEAT; HEAT repeat [structural motif]

pfam12348
Location:99 → 311

CLASP_N; CLASP N terminal
NM_001286603.1 → NP_001273532.1 CLIP-associating protein 2 isoform h

See identical proteins and their annotated locations for NP_001273532.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform h) that is shorter at both the N- and C-termini, compared to isoform c.

Source sequence(s)

AK005146, BC030468, CJ052159

UniProtKB/Swiss-Prot

Q8BRT1

Related

ENSMUST00000213966.2
NM_029633.2 → NP_083909.2 CLIP-associating protein 2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform a, which is shorter and has a distinct N-terminus, compared to isoform c.

Source sequence(s)

AC107803, AK164326, BC117963

Consensus CDS

CCDS52948.1

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

UniProtKB/TrEMBL

E9Q8N5

Related

ENSMUSP00000107469.3, ENSMUST00000111838.10

Conserved Domains (2) summary

pfam12348
Location:100 → 311

CLASP_N; CLASP N terminal

sd00044
Location:1056 → 1078

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

113567776..113748765

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512384.5 → XP_006512447.1 CLIP-associating protein 2 isoform X1

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (4) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal

pfam15782
Location:641 → 813

GREB1; Gene regulated by oestrogen in breast cancer
XM_006512385.5 → XP_006512448.1 CLIP-associating protein 2 isoform X2

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (4) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal

pfam15782
Location:641 → 813

GREB1; Gene regulated by oestrogen in breast cancer
XM_006512387.5 → XP_006512450.1 CLIP-associating protein 2 isoform X4

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (4) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal

pfam15782
Location:641 → 813

GREB1; Gene regulated by oestrogen in breast cancer
XM_036155382.1 → XP_036011275.1 CLIP-associating protein 2 isoform X7

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam15402
Location:687 → 809

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_006512391.5 → XP_006512454.1 CLIP-associating protein 2 isoform X11

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (4) summary

PHA03307
Location:652 → 803

PHA03307; transcriptional regulator ICP4; Provisional

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_006512392.5 → XP_006512455.1 CLIP-associating protein 2 isoform X12

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (4) summary

PHA03307
Location:652 → 803

PHA03307; transcriptional regulator ICP4; Provisional

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_030244700.2 → XP_030100560.1 CLIP-associating protein 2 isoform X17

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (4) summary

PHA03307
Location:652 → 803

PHA03307; transcriptional regulator ICP4; Provisional

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_036155381.1 → XP_036011274.1 CLIP-associating protein 2 isoform X6

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_006512390.5 → XP_006512453.1 CLIP-associating protein 2 isoform X9

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_030244699.2 → XP_030100559.1 CLIP-associating protein 2 isoform X10

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_006512393.5 → XP_006512456.1 CLIP-associating protein 2 isoform X14

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_036155385.1 → XP_036011278.1 CLIP-associating protein 2 isoform X16

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_036155388.1 → XP_036011281.1 CLIP-associating protein 2 isoform X21

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_030244701.2 → XP_030100561.1 CLIP-associating protein 2 isoform X24

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_030244702.2 → XP_030100562.1 CLIP-associating protein 2 isoform X25

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_006512386.5 → XP_006512449.1 CLIP-associating protein 2 isoform X3

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (4) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal

pfam15402
Location:681 → 803

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
XM_036155383.1 → XP_036011276.1 CLIP-associating protein 2 isoform X13

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_036155389.1 → XP_036011282.1 CLIP-associating protein 2 isoform X23

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_006512388.5 → XP_006512451.1 CLIP-associating protein 2 isoform X5

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (4) summary

PHA03307
Location:630 → 788

PHA03307; transcriptional regulator ICP4; Provisional

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_036155384.1 → XP_036011277.1 CLIP-associating protein 2 isoform X15

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_036155386.1 → XP_036011279.1 CLIP-associating protein 2 isoform X19

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_036155387.1 → XP_036011280.1 CLIP-associating protein 2 isoform X20

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_006512389.5 → XP_006512452.1 CLIP-associating protein 2 isoform X8

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (4) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal

pfam15402
Location:673 → 795

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
XM_006512394.5 → XP_006512457.1 CLIP-associating protein 2 isoform X18

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_006512397.5 → XP_006512460.1 CLIP-associating protein 2 isoform X22

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_030244703.2 → XP_030100563.1 CLIP-associating protein 2 isoform X26

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_030244704.2 → XP_030100564.1 CLIP-associating protein 2 isoform X27

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:327 → 538

CLASP_N; CLASP N terminal
XM_036155390.1 → XP_036011283.1 CLIP-associating protein 2 isoform X28

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_030244705.2 → XP_030100565.1 CLIP-associating protein 2 isoform X29

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (4) summary

sd00044
Location:1224 → 1246

HEAT; HEAT repeat [structural motif]

pfam02985
Location:69 → 99

HEAT; HEAT repeat

pfam12348
Location:228 → 439

CLASP_N; CLASP N terminal

pfam15782
Location:542 → 714

GREB1; Gene regulated by oestrogen in breast cancer
XM_030244707.2 → XP_030100567.1 CLIP-associating protein 2 isoform X30

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:1106 → 1128

HEAT; HEAT repeat [structural motif]

pfam12348
Location:109 → 321

CLASP_N; CLASP N terminal
XM_036155391.1 → XP_036011284.1 CLIP-associating protein 2 isoform X30

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:1106 → 1128

HEAT; HEAT repeat [structural motif]

pfam12348
Location:109 → 321

CLASP_N; CLASP N terminal
XM_006512396.3 → XP_006512459.1 CLIP-associating protein 2 isoform X32

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (3) summary

sd00044
Location:1090 → 1112

HEAT; HEAT repeat [structural motif]

pfam12348
Location:94 → 305

CLASP_N; CLASP N terminal

pfam15782
Location:408 → 580

GREB1; Gene regulated by oestrogen in breast cancer
XM_036155394.1 → XP_036011287.1 CLIP-associating protein 2 isoform X35

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:1072 → 1094

HEAT; HEAT repeat [structural motif]

pfam12348
Location:93 → 305

CLASP_N; CLASP N terminal
XM_036155399.1 → XP_036011292.1 CLIP-associating protein 2 isoform X40

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (2) summary

sd00044
Location:1043 → 1065

HEAT; HEAT repeat [structural motif]

pfam12348
Location:93 → 305

CLASP_N; CLASP N terminal
XM_036155396.1 → XP_036011289.1 CLIP-associating protein 2 isoform X37

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:1056 → 1078

HEAT; HEAT repeat [structural motif]

pfam12348
Location:93 → 305

CLASP_N; CLASP N terminal
XM_036155401.1 → XP_036011294.1 CLIP-associating protein 2 isoform X42

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (2) summary

sd00044
Location:1035 → 1057

HEAT; HEAT repeat [structural motif]

pfam12348
Location:93 → 305

CLASP_N; CLASP N terminal
XM_036155392.1 → XP_036011285.1 CLIP-associating protein 2 isoform X33

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:1076 → 1098

HEAT; HEAT repeat [structural motif]

pfam12348
Location:93 → 305

CLASP_N; CLASP N terminal
XM_036155395.1 → XP_036011288.1 CLIP-associating protein 2 isoform X36

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:1058 → 1080

HEAT; HEAT repeat [structural motif]

pfam12348
Location:93 → 305

CLASP_N; CLASP N terminal
XM_036155398.1 → XP_036011291.1 CLIP-associating protein 2 isoform X39

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (2) summary

sd00044
Location:1050 → 1072

HEAT; HEAT repeat [structural motif]

pfam12348
Location:93 → 305

CLASP_N; CLASP N terminal
XM_036155402.1 → XP_036011295.1 CLIP-associating protein 2 isoform X43

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (2) summary

sd00044
Location:1029 → 1051

HEAT; HEAT repeat [structural motif]

pfam12348
Location:93 → 305

CLASP_N; CLASP N terminal
XM_006512395.5 → XP_006512458.1 CLIP-associating protein 2 isoform X31

UniProtKB/TrEMBL

F7DCH5

Conserved Domains (3) summary

sd00044
Location:1096 → 1118

HEAT; HEAT repeat [structural motif]

pfam12348
Location:100 → 311

CLASP_N; CLASP N terminal

pfam15782
Location:414 → 586

GREB1; Gene regulated by oestrogen in breast cancer
XM_036155393.1 → XP_036011286.1 CLIP-associating protein 2 isoform X34

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (3) summary

PHA03307
Location:425 → 576

PHA03307; transcriptional regulator ICP4; Provisional

sd00044
Location:1075 → 1097

HEAT; HEAT repeat [structural motif]

pfam12348
Location:99 → 311

CLASP_N; CLASP N terminal
XM_036155397.1 → XP_036011290.1 CLIP-associating protein 2 isoform X38

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (2) summary

sd00044
Location:1048 → 1070

HEAT; HEAT repeat [structural motif]

pfam12348
Location:99 → 311

CLASP_N; CLASP N terminal
XM_036155400.1 → XP_036011293.1 CLIP-associating protein 2 isoform X41

UniProtKB/Swiss-Prot

Q8BRT1, Q8CHE3, Q99JI3, Q9DB80

Conserved Domains (2) summary

sd00044
Location:1034 → 1056

HEAT; HEAT repeat [structural motif]

pfam12348
Location:99 → 311

CLASP_N; CLASP N terminal